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@ARTICLE{Baker:141060,
      author       = {Baker, Suzanne L and Maaß, Anne and Jagust, William J},
      title        = {{C}onsiderations and code for partial volume correcting
                      [18{F}]-{AV}-1451 tau {PET} data.},
      journal      = {Data in Brief},
      volume       = {15},
      issn         = {2352-3409},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2020-07382},
      pages        = {648-657},
      year         = {2017},
      abstract     = {[18F]-AV-1451 is a leading tracer used with positron
                      emission tomography (PET) to quantify tau pathology.
                      However, [18F]-AV-1451 shows 'off target' or non-specific
                      binding, which we define as binding of the tracer in
                      unexpected areas unlikely to harbor aggregated tau based on
                      autopsy literature [1]. Along with caudate, putamen,
                      pallidum and thalamus non-specific binding [2], [3], we have
                      found binding in the superior portion of the cerebellar gray
                      matter, leading us to use inferior cerebellar gray as the
                      reference region. We also addressed binding in the posterior
                      portion of the choroid plexus. PET signal unlikely to be
                      associated with tau also occurs in skull, meninges and soft
                      tissue (see e.g. [4]). We refer to [18F]-AV-1451 binding in
                      the skull and meninges as extra-cortical hotspots (ECH) and
                      find them near lateral and medial orbitofrontal, lateral
                      occipital, inferior and middle temporal, superior and
                      inferior parietal, and inferior cerebellar gray matter.
                      Lastly, the choroid plexus also shows non-specific binding
                      that bleeds into hippocampus. We are providing the code
                      (http://www.runmycode.org/companion/view/2798) used to
                      create different regions of interest (ROIs) that we then
                      used to perform Partial Volume Correction (PVC) using the
                      Rousset geometric transfer matrix method (GTM, [5]). This
                      method was used in the companion article, 'Comparison of
                      multiple tau-PET measures as biomarkers in aging and
                      Alzheimer's Disease' ([6], DOI
                      10.1016/j.neuroimage.2017.05.058).},
      cin          = {AG Düzel},
      ddc          = {570},
      cid          = {I:(DE-2719)5000006},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29124088},
      pmc          = {pmc:PMC5671473},
      doi          = {10.1016/j.dib.2017.10.024},
      url          = {https://pub.dzne.de/record/141060},
}