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@ARTICLE{Pardias:141087,
author = {Pardiñas, Antonio F and Holmans, Peter and Pocklington,
Andrew J and Escott-Price, Valentina and Ripke, Stephan and
Carrera, Noa and Legge, Sophie E and Bishop, Sophie and
Cameron, Darren and Hamshere, Marian L and Han, Jun and
Hubbard, Leon and Lynham, Amy and Mantripragada, Kiran and
Rees, Elliott and MacCabe, James H and McCarroll, Steven A
and Baune, Bernhard T and Breen, Gerome and Byrne, Enda M
and Dannlowski, Udo and Eley, Thalia C and Hayward, Caroline
and Martin, Nicholas G and McIntosh, Andrew M and Plomin,
Robert and Porteous, David J and Wray, Naomi R and
Caballero, Armando and Geschwind, Daniel H and Huckins,
Laura M and Ruderfer, Douglas M and Santiago, Enrique and
Sklar, Pamela and Stahl, Eli A and Won, Hyejung and Agerbo,
Esben and Als, Thomas D and Andreassen, Ole A and
Bækvad-Hansen, Marie and Mortensen, Preben Bo and Pedersen,
Carsten Bøcker and Børglum, Anders D and Bybjerg-Grauholm,
Jonas and Djurovic, Srdjan and Durmishi, Naser and Pedersen,
Marianne Giørtz and Golimbet, Vera and Grove, Jakob and
Hougaard, David M and Mattheisen, Manuel and Molden, Espen
and Mors, Ole and Nordentoft, Merete and
Pejovic-Milovancevic, Milica and Sigurdsson, Engilbert and
Silagadze, Teimuraz and Hansen, Christine Søholm and
Stefansson, Kari and Stefansson, Hreinn and Steinberg, Stacy
and Tosato, Sarah and Werge, Thomas and Consortium, GERAD1
and Consortium, CRESTAR and Collier, David A and Rujescu,
Dan and Kirov, George and Owen, Michael J and O'Donovan,
Michael C and Walters, James T R and Harold, Denise and
Sims, Rebecca and Gerrish, Amy and Chapman, Jade and
Escott-Price, Valentina and Abraham, Richard and
Hollingworth, Paul and Pahwa, Jaspreet and Denning, Nicola
and Thomas, Charlene and Taylor, Sarah and Powell, John and
Proitsi, Petroula and Lupton, Michelle and Lovestone, Simon
and Passmore, Peter and Craig, David and McGuinness,
Bernadette and Johnston, Janet and Todd, Stephen and Maier,
Wolfgang and Jessen, Frank and Heun, Reiner and Schurmann,
Britta and Ramirez, Alfredo and Becker, Tim and Herold,
Christine and Lacour, André and Drichel, Dmitriy and
Nothen, Markus and Goate, Alison and Cruchaga, Carlos and
Nowotny, Petra and Morris, John C and Mayo, Kevin and
Holmans, Peter and O'Donovan, Michael and Owen, Michael and
Williams, Julie and Achilla, Evanthia and Agerbo, Esben and
Barr, Cathy L and Böttger, Theresa Wimberly and Breen,
Gerome and Cohen, Dan and Collier, David A and Curran, Sarah
and Dempster, Emma and Dima, Danai and Sabes-Figuera, Ramon
and Flanagan, Robert J and Frangou, Sophia and Frank, Josef
and Gasse, Christiane and Gaughran, Fiona and Giegling, Ina
and Grove, Jakob and Hannon, Eilis and Hartmann, Annette M
and Heißerer, Barbara and Helthuis, Marinka and Horsdal,
Henriette Thisted and Ingimarsson, Oddur and Jollie, Karel
and Kennedy, James L and Köhler, Ole and Konte, Bettina and
Lang, Maren and Legge, Sophie E and Lewis, Cathryn and
MacCabe, James and Malhotra, Anil K and McCrone, Paul and
Meier, Sandra M and Mill, Jonathan and Mors, Ole and
Mortensen, Preben Bo and Nöthen, Markus M and O'Donovan,
Michael C and Owen, Michael J and Pardiñas, Antonio F and
Pedersen, Carsten B and Rietschel, Marcella and Rujescu, Dan
and Schwalber, Ameli and Sigurdsson, Engilbert and
Sørensen, Holger J and Spencer, Benjamin and Stefansson,
Hreinn and Støvring, Henrik and Strohmaier, Jana and
Sullivan, Patrick and Vassos, Evangelos and Verbelen, Moira
and Walters, James T R and Werge, Thomas},
title = {{C}ommon schizophrenia alleles are enriched in
mutation-intolerant genes and in regions under strong
background selection.},
journal = {Nature genetics},
volume = {50},
number = {3},
issn = {1061-4036},
address = {London},
publisher = {Macmillan Publishers Limited, part of Springer Nature},
reportid = {DZNE-2020-07409},
pages = {381-389},
year = {2018},
abstract = {Schizophrenia is a debilitating psychiatric condition often
associated with poor quality of life and decreased life
expectancy. Lack of progress in improving treatment outcomes
has been attributed to limited knowledge of the underlying
biology, although large-scale genomic studies have begun to
provide insights. We report a new genome-wide association
study of schizophrenia (11,260 cases and 24,542 controls),
and through meta-analysis with existing data we identify 50
novel associated loci and 145 loci in total. Through
integrating genomic fine-mapping with brain expression and
chromosome conformation data, we identify candidate causal
genes within 33 loci. We also show for the first time that
the common variant association signal is highly enriched
among genes that are under strong selective pressures. These
findings provide new insights into the biology and genetic
architecture of schizophrenia, highlight the importance of
mutation-intolerant genes and suggest a mechanism by which
common risk variants persist in the population.},
keywords = {Alleles / Case-Control Studies / Gene Frequency / Genes,
Lethal: genetics / Genetic Loci / Genetic Predisposition to
Disease / Genome-Wide Association Study / Humans /
Inheritance Patterns / Polymorphism, Single Nucleotide /
Schizophrenia: genetics / Selection, Genetic},
cin = {GenomMathematik / AG Roes},
ddc = {570},
cid = {I:(DE-2719)1013007 / I:(DE-2719)1610003},
pnm = {345 - Population Studies and Genetics (POF3-345) / 344 -
Clinical and Health Care Research (POF3-344)},
pid = {G:(DE-HGF)POF3-345 / G:(DE-HGF)POF3-344},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:29483656},
pmc = {pmc:PMC5918692},
doi = {10.1038/s41588-018-0059-2},
url = {https://pub.dzne.de/record/141087},
}
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