%0 Journal Article
%A Kong, Xiang-Zhen
%A Mathias, Samuel R
%A Guadalupe, Tulio
%A Group, ENIGMA Laterality Working
%A Glahn, David C
%A Franke, Barbara
%A Crivello, Fabrice
%A Tzourio-Mazoyer, Nathalie
%A Fisher, Simon E
%A Thompson, Paul M
%A Francks, Clyde
%A Kong, Xiang-Zhen
%A Mathias, Samuel R
%A Guadalupe, Tulio
%A Abé, Christoph
%A Agartz, Ingrid
%A Akudjedu, Theophilus N
%A Aleman, Andre
%A Alhusaini, Saud
%A Allen, Nicholas B
%A Ames, David
%A Andreassen, Ole A
%A Vasquez, Alejandro Arias
%A Armstrong, Nicola J
%A Bergo, Felipe
%A Bastin, Mark E
%A Batalla, Albert
%A Bauer, Jochen
%A Baune, Bernhard T
%A Baur-Streubel, Ramona
%A Biederman, Joseph
%A Blaine, Sara K
%A Boedhoe, Premika
%A Bøen, Erlend
%A Bose, Anushree
%A Bralten, Janita
%A Brandeis, Daniel
%A Brem, Silvia
%A Brodaty, Henry
%A Yüksel, Dilara
%A Brooks, Samantha J
%A Buitelaar, Jan
%A Bürger, Christian
%A Bülow, Robin
%A Calhoun, Vince
%A Calvo, Anna
%A Canales-Rodríguez, Erick Jorge
%A Canive, Jose M
%A Cannon, Dara M
%A Caparelli, Elisabeth C
%A Castellanos, Francisco X
%A Cavalleri, Gianpiero L
%A Cendes, Fernando
%A Chaim-Avancini, Tiffany Moukbel
%A Chantiluke, Kaylita
%A Chen, Qun-Lin
%A Chen, Xiayu
%A Cheng, Yuqi
%A Christakou, Anastasia
%A Clark, Vincent P
%A Coghill, David
%A Connolly, Colm G
%A Conzelmann, Annette
%A Córdova-Palomera, Aldo
%A Cousijn, Janna
%A Crow, Tim
%A Cubillo, Ana
%A Dale, Anders
%A Dannlowski, Udo
%A Ambrosino de Bruttopilo, Sara
%A de Zeeuw, Patrick
%A Deary, Ian J
%A Delanty, Norman
%A Demeter, Damion V
%A Di Martino, Adriana
%A Dickie, Erin W
%A Dietsche, Bruno
%A Doan, N Trung
%A Doherty, Colin P
%A Doyle, Alysa
%A Durston, Sarah
%A Earl, Eric
%A Ehrlich, Stefan
%A Ekman, Carl Johan
%A Elvsåshagen, Torbjørn
%A Epstein, Jeffery N
%A Fair, Damien A
%A Faraone, Stephen V
%A Fernández, Guillén
%A Filho, Geraldo Busatto
%A Förster, Katharina
%A Fouche, Jean-Paul
%A Foxe, John J
%A Frodl, Thomas
%A Fuentes-Claramonte, Paola
%A Fullerton, Janice
%A Garavan, Hugh
%A Garcia, Danielle do Santos
%A Gotlib, Ian H
%A Goudriaan, Anna E
%A Grabe, Hans
%A Groenewold, Nynke A
%A Grotegerd, Dominik
%A Gruber, Oliver
%A Gurholt, Tiril
%A Haavik, Jan
%A Hahn, Tim
%A Hansell, Narelle K
%A Harris, Mathew A
%A Hartman, Catharina A
%A Hernández, Maria Del Carmen Valdés
%A Heslenfeld, Dirk
%A Hester, Robert
%A Hibar, Derrek Paul
%A Ho, Beng-Choon
%A Ho, Tiffany C
%A Hoekstra, Pieter J
%A van Holst, Ruth J
%A Hoogman, Martine
%A Høvik, Marie F
%A Howells, Fleur M
%A Hugdahl, Kenneth
%A Huyser, Chaim
%A Ingvar, Martin
%A Irwin, Lourdes
%A Ishikawa, Akari
%A James, Anthony
%A Jahanshad, Neda
%A Jernigan, Terry L
%A Jönsson, Erik G
%A Kähler, Claas
%A Kaleda, Vasily
%A Kelly, Clare
%A Kerich, Michael
%A Keshavan, Matcheri S
%A Khadka, Sabin
%A Kircher, Tilo
%A Kohls, Gregor
%A Konrad, Kerstin
%A Korucuoglu, Ozlem
%A Krämer, Bernd
%A Krug, Axel
%A Kwon, Jun Soo
%A Lambregts-Rommelse, Nanda
%A Landén, Mikael
%A Lázaro, Luisa
%A Lebedeva, Irina
%A Lenroot, Rhoshel
%A Lesch, Klaus-Peter
%A Li, Qinqin
%A Lim, Kelvin O
%A Liu, Jia
%A Lochner, Christine
%A London, Edythe D
%A Lonning, Vera
%A Lorenzetti, Valentina
%A Luciano, Michelle
%A Luijten, Maartje
%A Lundervold, Astri J
%A Mackey, Scott
%A MacMaster, Frank P
%A Maingault, Sophie
%A Malpas, Charles B
%A Malt, Ulrik F
%A Mataix-Cols, David
%A Martin-Santos, Rocio
%A Mayer, Andrew R
%A McCarthy, Hazel
%A Mitchell, Philip B
%A Mueller, Bryon A
%A Maniega, Susana Muñoz
%A Mazoyer, Bernard
%A McDonald, Colm
%A McLellan, Quinn
%A McMahon, Katie L
%A McPhilemy, Genevieve
%A Momenan, Reza
%A Morales, Angelica M
%A Narayanaswamy, Janardhanan C
%A Moreira, José Carlos Vasques
%A Nerland, Stener
%A Nestor, Liam
%A Newman, Erik
%A Nigg, Joel T
%A Nordvik, Jan Egil
%A Novotny, Stephanie
%A Weiss, Eileen Oberwelland
%A O'Gorman, Ruth L
%A Oosterlaan, Jaap
%A Oranje, Bob
%A Orr, Catherine
%A Overs, Bronwyn
%A Pauli, Paul
%A Paulus, Martin
%A Plessen, Kerstin Jessica
%A von Polier, Georg G
%A Pomarol-Clotet, Edith
%A Portella, Maria J
%A Qiu, Jiang
%A Radua, Joaquim
%A Ramos-Quiroga, Josep Antoni
%A Reddy, Y C Janardhan
%A Reif, Andreas
%A Roberts, Gloria
%A Rosa, Pedro
%A Rubia, Katya
%A Sacchet, Matthew D
%A Sachdev, Perminder S
%A Salvador, Raymond
%A Schmaal, Lianne
%A Schulte-Rüther, Martin
%A Schweren, Lizanne
%A Seidman, Larry
%A Seitz, Jochen
%A Serpa, Mauricio Henriques
%A Shaw, Philip
%A Shumskaya, Elena
%A Silk, Timothy J
%A Simmons, Alan N
%A Simulionyte, Egle
%A Sinha, Rajita
%A Sjoerds, Zsuzsika
%A Smelror, Runar Elle
%A Soliva, Joan Carlos
%A Solowij, Nadia
%A Souza-Duran, Fabio Luisde
%A Sponheim, Scott R
%A Stein, Dan J
%A Stein, Elliot A
%A Stevens, Michael
%A Strike, Lachlan T
%A Sudre, Gustavo
%A Sui, Jing
%A Tamm, Leanne
%A Temmingh, Hendrik S
%A Thoma, Robert J
%A Tomyshev, Alexander
%A Tronchin, Giulia
%A Turner, Jessica
%A Uhlmann, Anne
%A van Erp, Theo G M
%A van den Heuvel, Odile A
%A van der Meer, Dennis
%A van Eijk, Liza
%A Vance, Alasdair
%A Veer, Ilya M
%A Veltman, Dick J
%A Venkatasubramanian, Ganesan
%A Vilarroya, Oscar
%A Vives-Gilabert, Yolanda
%A Voineskos, Aristotle N
%A Völzke, Henry
%A Vuletic, Daniella
%A Walitza, Susanne
%A Walter, Henrik
%A Walton, Esther
%A Wardlaw, Joanna M
%A Wen, Wei
%A Westlye, Lars T
%A Whelan, Christopher D
%A White, Tonya
%A Wiers, Reinout W
%A Wright, Margaret J
%A Wittfeld, Katharina
%A Yang, Tony T
%A Yasuda, Clarissa L
%A Yoncheva, Yuliya
%A Yücel, Murat
%A Yun, Je-Yeon
%A Zanetti, Marcus Vinicius
%A Zhen, Zonglei
%A Zhu, Xing-Xing
%A Ziegler, Georg C
%A Zierhut, Kathrin
%A de Zubicaray, Greig I
%A Zwiers, Marcel
%A Glahn, David C
%A Franke, Barbara
%A Crivello, Fabrice
%A Tzourio-Mazoyer, Nathalie
%A Fisher, Simon E
%A Thompson, Paul M
%A Francks, Clyde
%A Farde, Lars
%A Flyckt, Lena
%A Engberg, Göran
%A Erhardt, Sophie
%A Fatouros-Bergman, Helena
%A Cervenka, Simon
%A Schwieler, Lilly
%A Piehl, Fredrik
%A Agartz, Ingrid
%A Collste, Karin
%A Victorsson, Pauliina
%A Malmqvist, Anna
%A Hedberg, Mikael
%A Orhan, Funda
%T Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium.
%J Proceedings of the National Academy of Sciences of the United States of America
%V 115
%N 22
%@ 0027-8424
%C Washington, DC
%I National Acad. of Sciences
%M DZNE-2020-07428
%P E5154-E5163
%D 2018
%X Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here, the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium presents the largest-ever analysis of cerebral cortical asymmetry and its variability across individuals. Cortical thickness and surface area were assessed in MRI scans of 17,141 healthy individuals from 99 datasets worldwide. Results revealed widespread asymmetries at both hemispheric and regional levels, with a generally thicker cortex but smaller surface area in the left hemisphere relative to the right. Regionally, asymmetries of cortical thickness and/or surface area were found in the inferior frontal gyrus, transverse temporal gyrus, parahippocampal gyrus, and entorhinal cortex. These regions are involved in lateralized functions, including language and visuospatial processing. In addition to population-level asymmetries, variability in brain asymmetry was related to sex, age, and intracranial volume. Interestingly, we did not find significant associations between asymmetries and handedness. Finally, with two independent pedigree datasets (n = 1,443 and 1,113, respectively), we found several asymmetries showing significant, replicable heritability. The structural asymmetries identified and their variabilities and heritability provide a reference resource for future studies on the genetic basis of brain asymmetry and altered laterality in cognitive, neurological, and psychiatric disorders.
%K Adolescent
%K Adult
%K Aged
%K Aged, 80 and over
%K Cerebral Cortex: diagnostic imaging
%K Child
%K Child, Preschool
%K Databases, Factual: statistics & numerical data
%K Female
%K Humans
%K Infant
%K Male
%K Middle Aged
%K Neuroimaging: methods
%K Young Adult
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29764998
%2 pmc:PMC5984496
%R 10.1073/pnas.1718418115
%U https://pub.dzne.de/record/141106