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@ARTICLE{Turimella:141160,
      author       = {Turimella, Sada Lakshmi and Bedner, Peter and Skubal,
                      Magdalena and Vangoor, Vamshidhar Reddy and Kaczmarczyk,
                      Lech and Karl, Kevin and Zoidl, Georg and Gieselmann,
                      Volkmar and Seifert, Gerald and Steinhäuser, Christian and
                      Kandel, Eric and Theis, Martin},
      title        = {{C}haracterization of cytoplasmic polyadenylation element
                      binding 2 protein expression and its {RNA} binding
                      activity.},
      journal      = {Hippocampus},
      volume       = {25},
      number       = {5},
      issn         = {1050-9631},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley},
      reportid     = {DZNE-2020-07482},
      pages        = {630-642},
      year         = {2015},
      abstract     = {Cytoplasmic polyadenylation element binding (CPEB) proteins
                      are translational regulators that are involved in the
                      control of cellular senescence, synaptic plasticity,
                      learning, and memory. We have previously found all four
                      known CPEB family members to be transcribed in the mouse
                      hippocampus. Aside from a brief description of CPEB2 in
                      mouse brain, not much is known about its biological role.
                      Hence, this study aims to investigate CPEB2 expression in
                      mouse brain. With reverse transcription polymerase chain
                      reaction (RT-PCR) of total mouse brain cDNA, we identified
                      four distinct CPEB2 splice variants. Single-cell RT-PCR
                      showed that CPEB2 is predominantly expressed in neurons of
                      the juvenile and adult brain and that individual cells
                      express different sets of splice variants. Staining of brain
                      slices with a custom-made CPEB2 antibody revealed ubiquitous
                      expression of the protein in many brain regions, including
                      hippocampus, striatum, thalamus, cortex, and cerebellum. We
                      also found differential expression of CPEB2 protein in
                      excitatory, inhibitory, and dopaminergic neurons. In primary
                      hippocampal cultures, the subcellular localization of CPEB2
                      in neurons and astrocytes resembled that of CPEB1.
                      Electrophoretic mobility shift assay and RNA
                      coimmunoprecipitation revealed CPEB2 interaction with
                      β-catenin and Ca(2+) /calmodulin-dependent protein kinase
                      II (both established CPEB1 targets), indicating an overlap
                      in RNA binding specificity between CPEB1 and CPEB2.
                      Furthermore, we identified ephrin receptor A4 as a putative
                      novel target of CPEB2. In conclusion, our study identifies
                      CPEB2 splice variants to be differentially expressed among
                      individual cells and across cell types of the mouse
                      hippocampus, and reveals overlapping binding specificity
                      between CPEB2 and CPEB1.},
      keywords     = {Animals / Astrocytes: metabolism / Brain: growth $\&$
                      development / Brain: metabolism /
                      Calcium-Calmodulin-Dependent Protein Kinase Type 2:
                      metabolism / HeLa Cells / Humans / Mice / Neurons:
                      metabolism / Protein Isoforms / RNA: metabolism / RNA,
                      Messenger: metabolism / RNA-Binding Proteins: genetics /
                      RNA-Binding Proteins: metabolism / Receptor, EphA4:
                      metabolism / Transcription Factors: genetics / Transcription
                      Factors: metabolism / Transfection / beta Catenin:
                      metabolism / mRNA Cleavage and Polyadenylation Factors:
                      genetics / mRNA Cleavage and Polyadenylation Factors:
                      metabolism / CPEB2 protein, mouse (NLM Chemicals) / Cpeb1
                      protein, mouse (NLM Chemicals) / Protein Isoforms (NLM
                      Chemicals) / RNA, Messenger (NLM Chemicals) / RNA-Binding
                      Proteins (NLM Chemicals) / Transcription Factors (NLM
                      Chemicals) / beta Catenin (NLM Chemicals) / mRNA Cleavage
                      and Polyadenylation Factors (NLM Chemicals) / RNA (NLM
                      Chemicals) / Receptor, EphA4 (NLM Chemicals) /
                      Calcium-Calmodulin-Dependent Protein Kinase Type 2 (NLM
                      Chemicals)},
      cin          = {AG Jackson},
      ddc          = {610},
      cid          = {I:(DE-2719)1013019},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25483308},
      doi          = {10.1002/hipo.22399},
      url          = {https://pub.dzne.de/record/141160},
}