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| 001 | 141300 | ||
| 005 | 20240429115959.0 | ||
| 024 | 7 | _ | |a 10.1038/ncomms6209 |2 doi |
| 024 | 7 | _ | |a pmid:25385546 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC4239663 |2 pmc |
| 024 | 7 | _ | |a altmetric:2879575 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-07622 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Coles, Charlotte H |0 P:(DE-2719)2810781 |b 0 |e First author |u dzne |
| 245 | _ | _ | |a Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis. |
| 260 | _ | _ | |a [London] |c 2014 |b Nature Publishing Group UK |
| 264 | _ | 1 | |3 online |2 Crossref |b Springer Science and Business Media LLC |c 2014-11-11 |
| 264 | _ | 1 | |3 print |2 Crossref |b Springer Science and Business Media LLC |c 2014-12-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1714381110_21076 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Receptor protein tyrosine phosphatase sigma (RPTPσ) regulates neuronal extension and acts as a presynaptic nexus for multiple protein and proteoglycan interactions during synaptogenesis. Unknown mechanisms govern the shift in RPTPσ function, from outgrowth promotion to synaptic organization. Here, we report crystallographic, electron microscopic and small-angle X-ray scattering analyses, which reveal sufficient inter-domain flexibility in the RPTPσ extracellular region for interaction with both cis (same cell) and trans (opposite cell) ligands. Crystal structures of RPTPσ bound to its postsynaptic ligand TrkC detail an interaction surface partially overlapping the glycosaminoglycan-binding site. Accordingly, heparan sulphate and heparin oligomers compete with TrkC for RPTPσ binding in vitro and disrupt TrkC-dependent synaptic differentiation in neuronal co-culture assays. We propose that transient RPTPσ ectodomain emergence from the presynaptic proteoglycan layer allows capture by TrkC to form a trans-synaptic complex, the consequent reduction in RPTPσ flexibility potentiating interactions with additional ligands to orchestrate excitatory synapse formation. |
| 536 | _ | _ | |a 341 - Molecular Signaling (POF3-341) |0 G:(DE-HGF)POF3-341 |c POF3-341 |f POF III |x 0 |
| 542 | _ | _ | |i 2014-11-11 |2 Crossref |u https://creativecommons.org/licenses/by/4.0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Extracellular Matrix Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Ligands |2 NLM Chemicals |
| 650 | _ | 7 | |a Proteoglycans |2 NLM Chemicals |
| 650 | _ | 7 | |a Receptor, trkC |0 EC 2.7.10.1 |2 NLM Chemicals |
| 650 | _ | 7 | |a Receptor-Like Protein Tyrosine Phosphatases, Class 2 |0 EC 3.1.3.48 |2 NLM Chemicals |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Cell Differentiation: physiology |2 MeSH |
| 650 | _ | 2 | |a Chick Embryo |2 MeSH |
| 650 | _ | 2 | |a Coculture Techniques |2 MeSH |
| 650 | _ | 2 | |a Crystallization |2 MeSH |
| 650 | _ | 2 | |a Extracellular Matrix Proteins: chemistry |2 MeSH |
| 650 | _ | 2 | |a Extracellular Matrix Proteins: physiology |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Ligands |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Neurogenesis: physiology |2 MeSH |
| 650 | _ | 2 | |a Neurons: cytology |2 MeSH |
| 650 | _ | 2 | |a Neurons: physiology |2 MeSH |
| 650 | _ | 2 | |a Protein Binding |2 MeSH |
| 650 | _ | 2 | |a Protein Structure, Tertiary |2 MeSH |
| 650 | _ | 2 | |a Proteoglycans: chemistry |2 MeSH |
| 650 | _ | 2 | |a Proteoglycans: physiology |2 MeSH |
| 650 | _ | 2 | |a Receptor, trkC: chemistry |2 MeSH |
| 650 | _ | 2 | |a Receptor, trkC: physiology |2 MeSH |
| 650 | _ | 2 | |a Receptor-Like Protein Tyrosine Phosphatases, Class 2: chemistry |2 MeSH |
| 650 | _ | 2 | |a Receptor-Like Protein Tyrosine Phosphatases, Class 2: physiology |2 MeSH |
| 650 | _ | 2 | |a Signal Transduction: physiology |2 MeSH |
| 650 | _ | 2 | |a Synapses: physiology |2 MeSH |
| 700 | 1 | _ | |a Mitakidis, Nikolaos |b 1 |
| 700 | 1 | _ | |a Zhang, Peng |b 2 |
| 700 | 1 | _ | |a Elegheert, Jonathan |b 3 |
| 700 | 1 | _ | |a Lu, Weixian |b 4 |
| 700 | 1 | _ | |a Stoker, Andrew W |b 5 |
| 700 | 1 | _ | |a Nakagawa, Terunaga |b 6 |
| 700 | 1 | _ | |a Craig, Ann Marie |b 7 |
| 700 | 1 | _ | |a Jones, E Yvonne |0 P:(DE-HGF)0 |b 8 |e Corresponding author |
| 700 | 1 | _ | |a Aricescu, A Radu |b 9 |
| 773 | 1 | 8 | |a 10.1038/ncomms6209 |b : Springer Science and Business Media LLC, 2014-11-11 |n 1 |p 5209 |3 journal-article |2 Crossref |t Nature Communications |v 5 |y 2014 |x 2041-1723 |
| 773 | _ | _ | |a 10.1038/ncomms6209 |g Vol. 5, no. 1, p. 5209 |0 PERI:(DE-600)2553671-0 |n 1 |q 5:1<5209 |p 5209 |t Nature Communications |v 5 |y 2014 |x 2041-1723 |
| 856 | 4 | _ | |u https://www.nature.com/articles/ncomms6209 |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239663 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/141300/files/DZNE-2020-07622.pdf |y OpenAccess |
| 856 | 4 | _ | |u https://pub.dzne.de/record/141300/files/DZNE-2020-07622.pdf?subformat=pdfa |x pdfa |y OpenAccess |
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| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.conb.2010.08.016 |2 Crossref |o 10.1016/j.conb.2010.08.016 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1146/annurev.neuro.051508.135302 |2 Crossref |o 10.1146/annurev.neuro.051508.135302 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1126/science.1198701 |2 Crossref |o 10.1126/science.1198701 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.conb.2007.01.011 |2 Crossref |o 10.1016/j.conb.2007.01.011 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1126/science.1232322 |2 Crossref |o 10.1126/science.1232322 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1152/physrev.00016.2002 |2 Crossref |o 10.1152/physrev.00016.2002 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nn1416 |2 Crossref |o 10.1038/nn1416 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.tins.2013.06.002 |2 Crossref |o 10.1016/j.tins.2013.06.002 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.tcb.2013.07.004 |2 Crossref |o 10.1016/j.tcb.2013.07.004 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1128/MCB.22.6.1881-1892.2002 |2 Crossref |o 10.1128/MCB.22.6.1881-1892.2002 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.cub.2005.08.035 |2 Crossref |o 10.1016/j.cub.2005.08.035 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neuron.2006.01.026 |2 Crossref |o 10.1016/j.neuron.2006.01.026 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1126/science.1178310 |2 Crossref |o 10.1126/science.1178310 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1126/science.1200840 |2 Crossref |o 10.1126/science.1200840 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.1737-11.2011 |2 Crossref |o 10.1523/JNEUROSCI.1737-11.2011 |
| 999 | C | 5 | |y 2010 |2 Crossref |o EJ Fry 2010 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neuron.2010.12.024 |2 Crossref |o 10.1016/j.neuron.2010.12.024 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.M109.061127 |2 Crossref |o 10.1074/jbc.M109.061127 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.4637-11.2012 |2 Crossref |o 10.1523/JNEUROSCI.4637-11.2012 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.1209881110 |2 Crossref |o 10.1073/pnas.1209881110 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.92.25.11686 |2 Crossref |o 10.1073/pnas.92.25.11686 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.jmb.2011.03.013 |2 Crossref |o 10.1016/j.jmb.2011.03.013 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.str.2010.06.005 |2 Crossref |o 10.1016/j.str.2010.06.005 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.tcb.2012.03.004 |2 Crossref |o 10.1016/j.tcb.2012.03.004 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1126/science.1144646 |2 Crossref |o 10.1126/science.1144646 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.cell.2014.01.004 |2 Crossref |o 10.1016/j.cell.2014.01.004 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nn.2279 |2 Crossref |o 10.1038/nn.2279 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nn.3040 |2 Crossref |o 10.1038/nn.3040 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.2136-11.2011 |2 Crossref |o 10.1523/JNEUROSCI.2136-11.2011 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/hmg/ddr418 |2 Crossref |o 10.1093/hmg/ddr418 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/jnr.490410303 |2 Crossref |o 10.1002/jnr.490410303 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/0896-6273(93)90211-9 |2 Crossref |o 10.1016/0896-6273(93)90211-9 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nature05453 |2 Crossref |o 10.1038/nature05453 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/6859 |2 Crossref |o 10.1038/6859 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/6866 |2 Crossref |o 10.1038/6866 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.94.26.14776 |2 Crossref |o 10.1073/pnas.94.26.14776 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/368249a0 |2 Crossref |o 10.1038/368249a0 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1111/j.1471-4159.2012.07762.x |2 Crossref |o 10.1111/j.1471-4159.2012.07762.x |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1111/j.1471-4159.2011.07411.x |2 Crossref |o 10.1111/j.1471-4159.2011.07411.x |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.95.13.7469 |2 Crossref |o 10.1073/pnas.95.13.7469 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nature11059 |2 Crossref |o 10.1038/nature11059 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.1117881109 |2 Crossref |o 10.1073/pnas.1117881109 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neuron.2013.06.029 |2 Crossref |o 10.1016/j.neuron.2013.06.029 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neuron.2013.06.049 |2 Crossref |o 10.1016/j.neuron.2013.06.049 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.cell.2010.04.035 |2 Crossref |o 10.1016/j.cell.2010.04.035 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.0470-10.2010 |2 Crossref |o 10.1523/JNEUROSCI.0470-10.2010 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nature10183 |2 Crossref |o 10.1038/nature10183 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nrn3379 |2 Crossref |o 10.1038/nrn3379 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1083/jcb.138.3.681 |2 Crossref |o 10.1083/jcb.138.3.681 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1128/MCB.23.19.6909-6921.2003 |2 Crossref |o 10.1128/MCB.23.19.6909-6921.2003 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1107/S0907444906029799 |2 Crossref |o 10.1107/S0907444906029799 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1107/S0021889809045701 |2 Crossref |o 10.1107/S0021889809045701 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1126/science.1218231 |2 Crossref |o 10.1126/science.1218231 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/bioinformatics/bti770 |2 Crossref |o 10.1093/bioinformatics/bti770 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1107/S0021889807021206 |2 Crossref |o 10.1107/S0021889807021206 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1107/S0907444904019158 |2 Crossref |o 10.1107/S0907444904019158 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1107/S0907444996012255 |2 Crossref |o 10.1107/S0907444996012255 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1107/S0907444909052925 |2 Crossref |o 10.1107/S0907444909052925 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1107/S0907444904016427 |2 Crossref |o 10.1107/S0907444904016427 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/nar/gkm216 |2 Crossref |o 10.1093/nar/gkm216 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/bip.360221211 |2 Crossref |o 10.1002/bip.360221211 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/0022-2836(79)90416-9 |2 Crossref |o 10.1016/0022-2836(79)90416-9 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.181342398 |2 Crossref |o 10.1073/pnas.181342398 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1251/bpo70 |2 Crossref |o 10.1251/bpo70 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1006/jsbi.1996.0030 |2 Crossref |o 10.1006/jsbi.1996.0030 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1107/S0909049513010431 |2 Crossref |o 10.1107/S0909049513010431 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1107/S0021889812007662 |2 Crossref |o 10.1107/S0021889812007662 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.str.2013.02.004 |2 Crossref |o 10.1016/j.str.2013.02.004 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nprot.2006.356 |2 Crossref |o 10.1038/nprot.2006.356 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.cell.2004.11.035 |2 Crossref |o 10.1016/j.cell.2004.11.035 |
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