000141301 001__ 141301
000141301 005__ 20240429110028.0
000141301 0247_ $$2doi$$a10.1038/ncomms7643
000141301 0247_ $$2pmid$$apmid:25851096
000141301 0247_ $$2altmetric$$aaltmetric:3891169
000141301 037__ $$aDZNE-2020-07623
000141301 041__ $$aEnglish
000141301 082__ $$a500
000141301 1001_ $$aIacovella, Maria G$$b0
000141301 245__ $$aRio1 promotes rDNA stability and downregulates RNA polymerase I to ensure rDNA segregation.
000141301 260__ $$a[London]$$bNature Publishing Group UK$$c2015
000141301 264_1 $$2Crossref$$3online$$bSpringer Science and Business Media LLC$$c2015-04-08
000141301 264_1 $$2Crossref$$3print$$bSpringer Science and Business Media LLC$$c2015-05-01
000141301 3367_ $$2DRIVER$$aarticle
000141301 3367_ $$2DataCite$$aOutput Types/Journal article
000141301 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1714381187_21078
000141301 3367_ $$2BibTeX$$aARTICLE
000141301 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000141301 3367_ $$00$$2EndNote$$aJournal Article
000141301 520__ $$aThe conserved protein kinase Rio1 localizes to the cytoplasm and nucleus of eukaryotic cells. While the roles of Rio1 in the cytoplasm are well characterized, its nuclear function remains unknown. Here we show that nuclear Rio1 promotes rDNA array stability and segregation in Saccharomyces cerevisiae. During rDNA replication in S phase, Rio1 downregulates RNA polymerase I (PolI) and recruits the histone deacetylase Sir2. Both interventions ensure rDNA copy-number homeostasis and prevent the formation of extrachromosomal rDNA circles, which are linked to accelerated ageing in yeast. During anaphase, Rio1 downregulates PolI by targeting its subunit Rpa43, causing PolI to dissociate from the rDNA. By stimulating the processing of PolI-generated transcripts at the rDNA, Rio1 allows for rDNA condensation and segregation in late anaphase. These events finalize the genome transmission process. We identify Rio1 as an essential nucleolar housekeeper that integrates rDNA replication and segregation with ribosome biogenesis.
000141301 536__ $$0G:(DE-HGF)POF3-341$$a341 - Molecular Signaling (POF3-341)$$cPOF3-341$$fPOF III$$x0
000141301 542__ $$2Crossref$$i2015-04-08$$uhttp://www.springer.com/tdm
000141301 588__ $$aDataset connected to CrossRef, PubMed,
000141301 650_7 $$2NLM Chemicals$$aDNA, Ribosomal
000141301 650_7 $$2NLM Chemicals$$aDNA-Binding Proteins
000141301 650_7 $$2NLM Chemicals$$aRpa43 protein, S cerevisiae
000141301 650_7 $$2NLM Chemicals$$aSaccharomyces cerevisiae Proteins
000141301 650_7 $$2NLM Chemicals$$aSilent Information Regulator Proteins, Saccharomyces cerevisiae
000141301 650_7 $$0EC 2.7.11.1$$2NLM Chemicals$$aProtein-Serine-Threonine Kinases
000141301 650_7 $$0EC 2.7.11.1$$2NLM Chemicals$$aRio1 protein, S cerevisiae
000141301 650_7 $$0EC 2.7.7.6$$2NLM Chemicals$$aRNA Polymerase I
000141301 650_7 $$0EC 3.5.1.-$$2NLM Chemicals$$aSIR2 protein, S cerevisiae
000141301 650_7 $$0EC 3.5.1.-$$2NLM Chemicals$$aSirtuin 2
000141301 650_2 $$2MeSH$$aAnaphase: genetics
000141301 650_2 $$2MeSH$$aChromosome Segregation: genetics
000141301 650_2 $$2MeSH$$aDNA Replication: genetics
000141301 650_2 $$2MeSH$$aDNA, Ribosomal: metabolism
000141301 650_2 $$2MeSH$$aDNA-Binding Proteins: genetics
000141301 650_2 $$2MeSH$$aDown-Regulation
000141301 650_2 $$2MeSH$$aProtein-Serine-Threonine Kinases: genetics
000141301 650_2 $$2MeSH$$aRNA Polymerase I: genetics
000141301 650_2 $$2MeSH$$aS Phase: genetics
000141301 650_2 $$2MeSH$$aSaccharomyces cerevisiae
000141301 650_2 $$2MeSH$$aSaccharomyces cerevisiae Proteins: genetics
000141301 650_2 $$2MeSH$$aSilent Information Regulator Proteins, Saccharomyces cerevisiae: genetics
000141301 650_2 $$2MeSH$$aSirtuin 2: genetics
000141301 7001_ $$0P:(DE-2719)2810498$$aGolfieri, Cristina$$b1$$udzne
000141301 7001_ $$aMassari, Lucia F$$b2
000141301 7001_ $$aBusnelli, Sara$$b3
000141301 7001_ $$aPagliuca, Cinzia$$b4
000141301 7001_ $$0P:(DE-2719)9001185$$aDal Maschio, Marianna$$b5$$udzne
000141301 7001_ $$0P:(DE-2719)9001184$$aInfantino, Valentina$$b6$$udzne
000141301 7001_ $$aVisintin, Rosella$$b7
000141301 7001_ $$aMechtler, Karl$$b8
000141301 7001_ $$aFerreira-Cerca, Sébastien$$b9
000141301 7001_ $$0P:(DE-HGF)0$$aDe Wulf, Peter$$b10$$eCorresponding author
000141301 77318 $$2Crossref$$3journal-article$$a10.1038/ncomms7643$$b : Springer Science and Business Media LLC, 2015-04-08$$n1$$p6643$$tNature Communications$$v6$$x2041-1723$$y2015
000141301 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/ncomms7643$$gVol. 6, no. 1, p. 6643$$n1$$p6643$$q6:1<6643$$tNature Communications$$v6$$x2041-1723$$y2015
000141301 8564_ $$uhttps://pub.dzne.de/record/141301/files/DZNE-2020-07623_Restricted.pdf
000141301 8564_ $$uhttps://pub.dzne.de/record/141301/files/DZNE-2020-07623_Restricted.pdf?subformat=pdfa$$xpdfa
000141301 909CO $$ooai:pub.dzne.de:141301$$pVDB
000141301 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810498$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000141301 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001185$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000141301 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001184$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b6$$kDZNE
000141301 9131_ $$0G:(DE-HGF)POF3-341$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vMolecular Signaling$$x0
000141301 9141_ $$y2015
000141301 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNAT COMMUN : 2017
000141301 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000141301 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000141301 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000141301 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central
000141301 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal
000141301 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ
000141301 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Blind peer review
000141301 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ
000141301 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000141301 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000141301 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000141301 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000141301 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences
000141301 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000141301 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences
000141301 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record
000141301 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000141301 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bNAT COMMUN : 2017
000141301 9201_ $$0I:(DE-2719)6000013$$kDresden common$$lDresden common$$x0
000141301 980__ $$ajournal
000141301 980__ $$aVDB
000141301 980__ $$aI:(DE-2719)6000013
000141301 980__ $$aUNRESTRICTED
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1128/MCB.00693-06$$o10.1128/MCB.00693-06
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0092-8674(04)00415-5$$o10.1016/S0092-8674(04)00415-5
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cub.2008.06.058$$o10.1016/j.cub.2008.06.058
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nature07652$$o10.1038/nature07652
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1534/genetics.113.153197$$o10.1534/genetics.113.153197
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1242/jcs.111948$$o10.1242/jcs.111948
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0092-8674(04)00413-1$$o10.1016/S0092-8674(04)00413-1
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1042/BST20120317$$o10.1042/BST20120317
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.R500013200$$o10.1074/jbc.R500013200
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.bbapap.2005.07.037$$o10.1016/j.bbapap.2005.07.037
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.R113.538090$$o10.1074/jbc.R113.538090
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/nar/gku542$$o10.1093/nar/gku542
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nsmb.2403$$o10.1038/nsmb.2403
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/nar/gkt720$$o10.1093/nar/gkt720
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/emboj/20.15.4204$$o10.1093/emboj/20.15.4204
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1128/MCB.23.6.2083-2095.2003$$o10.1128/MCB.23.6.2083-2095.2003
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/nar/gku815$$o10.1093/nar/gku815
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/nar/gku878$$o10.1093/nar/gku878
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.4161/rna.18810$$o10.4161/rna.18810
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1091/mbc.e11-07-0639$$o10.1091/mbc.e11-07-0639
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1046/j.1365-2958.2002.02881.x$$o10.1046/j.1365-2958.2002.02881.x
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1742-4658.2007.05993.x$$o10.1111/j.1742-4658.2007.05993.x
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.1176495$$o10.1126/science.1176495
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1101/gad.1108403$$o10.1101/gad.1108403
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/nar/gkr1029$$o10.1093/nar/gkr1029
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.ceb.2009.09.002$$o10.1016/j.ceb.2009.09.002
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.2183/pjab.90.119$$o10.2183/pjab.90.119
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.dnarep.2008.06.010$$o10.1016/j.dnarep.2008.06.010
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.molcel.2009.07.012$$o10.1016/j.molcel.2009.07.012
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cub.2013.07.048$$o10.1016/j.cub.2013.07.048
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/19775$$o10.1038/19775
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/sj.emboj.7601488$$o10.1038/sj.emboj.7601488
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0092-8674(04)00414-3$$o10.1016/S0092-8674(04)00414-3
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.dnarep.2009.01.015$$o10.1016/j.dnarep.2009.01.015
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/emboj/18.22.6561$$o10.1093/emboj/18.22.6561
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.1116102$$o10.1126/science.1116102
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1101/gad.340205$$o10.1101/gad.340205
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nature00769$$o10.1038/nature00769
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/wrna.57$$o10.1002/wrna.57
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M111.268649$$o10.1074/jbc.M111.268649
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1271/bbb.59.1869$$o10.1271/bbb.59.1869
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1101/gad.17363311$$o10.1101/gad.17363311
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M112.444265$$o10.1074/jbc.M112.444265
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nprot.2012.036$$o10.1038/nprot.2012.036
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1742-4658.2005.04796.x$$o10.1111/j.1742-4658.2005.04796.x
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.274.41.29260$$o10.1074/jbc.274.41.29260
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.272.20.12961$$o10.1074/jbc.272.20.12961
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nature07460$$o10.1038/nature07460
000141301 999C5 $$2Crossref$$oX He 1998$$y1998
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1006/jmbi.2000.4095$$o10.1006/jmbi.2000.4095
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.bbaexp.2006.10.004$$o10.1016/j.bbaexp.2006.10.004
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.142.6.1487$$o10.1083/jcb.142.6.1487
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/nar/gkm1093$$o10.1093/nar/gkm1093
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/mcp.M700468-MCP200$$o10.1074/mcp.M700468-MCP200
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.1172867$$o10.1126/science.1172867
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cell.2007.10.051$$o10.1016/j.cell.2007.10.051
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nature12636$$o10.1038/nature12636
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1091/mbc.e04-06-0515$$o10.1091/mbc.e04-06-0515
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1101/gad.1085403$$o10.1101/gad.1085403
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.90.16.7637$$o10.1073/pnas.90.16.7637
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1371/journal.pone.0037371$$o10.1371/journal.pone.0037371
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/0005-2787(78)90267-8$$o10.1016/0005-2787(78)90267-8
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/emboj/17.24.7373$$o10.1093/emboj/17.24.7373
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.200201024$$o10.1083/jcb.200201024
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.200405013$$o10.1083/jcb.200405013
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0014-5793(99)00258-6$$o10.1016/S0014-5793(99)00258-6
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0022-2836(02)00110-9$$o10.1016/S0022-2836(02)00110-9
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/1044-0305(94)80016-2$$o10.1016/1044-0305(94)80016-2
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1021/pr500202e$$o10.1021/pr500202e
000141301 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/msb.2011.75$$o10.1038/msb.2011.75