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@ARTICLE{Iacovella:141301,
      author       = {Iacovella, Maria G and Golfieri, Cristina and Massari,
                      Lucia F and Busnelli, Sara and Pagliuca, Cinzia and Dal
                      Maschio, Marianna and Infantino, Valentina and Visintin,
                      Rosella and Mechtler, Karl and Ferreira-Cerca, Sébastien
                      and De Wulf, Peter},
      title        = {{R}io1 promotes r{DNA} stability and downregulates {RNA}
                      polymerase {I} to ensure r{DNA} segregation.},
      journal      = {Nature Communications},
      volume       = {6},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DZNE-2020-07623},
      pages        = {6643},
      year         = {2015},
      abstract     = {The conserved protein kinase Rio1 localizes to the
                      cytoplasm and nucleus of eukaryotic cells. While the roles
                      of Rio1 in the cytoplasm are well characterized, its nuclear
                      function remains unknown. Here we show that nuclear Rio1
                      promotes rDNA array stability and segregation in
                      Saccharomyces cerevisiae. During rDNA replication in S
                      phase, Rio1 downregulates RNA polymerase I (PolI) and
                      recruits the histone deacetylase Sir2. Both interventions
                      ensure rDNA copy-number homeostasis and prevent the
                      formation of extrachromosomal rDNA circles, which are linked
                      to accelerated ageing in yeast. During anaphase, Rio1
                      downregulates PolI by targeting its subunit Rpa43, causing
                      PolI to dissociate from the rDNA. By stimulating the
                      processing of PolI-generated transcripts at the rDNA, Rio1
                      allows for rDNA condensation and segregation in late
                      anaphase. These events finalize the genome transmission
                      process. We identify Rio1 as an essential nucleolar
                      housekeeper that integrates rDNA replication and segregation
                      with ribosome biogenesis.},
      keywords     = {Anaphase: genetics / Chromosome Segregation: genetics / DNA
                      Replication: genetics / DNA, Ribosomal: metabolism /
                      DNA-Binding Proteins: genetics / Down-Regulation /
                      Protein-Serine-Threonine Kinases: genetics / RNA Polymerase
                      I: genetics / S Phase: genetics / Saccharomyces cerevisiae /
                      Saccharomyces cerevisiae Proteins: genetics / Silent
                      Information Regulator Proteins, Saccharomyces cerevisiae:
                      genetics / Sirtuin 2: genetics / DNA, Ribosomal (NLM
                      Chemicals) / DNA-Binding Proteins (NLM Chemicals) / Rpa43
                      protein, S cerevisiae (NLM Chemicals) / Saccharomyces
                      cerevisiae Proteins (NLM Chemicals) / Silent Information
                      Regulator Proteins, Saccharomyces cerevisiae (NLM Chemicals)
                      / Protein-Serine-Threonine Kinases (NLM Chemicals) / Rio1
                      protein, S cerevisiae (NLM Chemicals) / RNA Polymerase I
                      (NLM Chemicals) / SIR2 protein, S cerevisiae (NLM Chemicals)
                      / Sirtuin 2 (NLM Chemicals)},
      cin          = {Dresden common},
      ddc          = {500},
      cid          = {I:(DE-2719)6000013},
      pnm          = {341 - Molecular Signaling (POF3-341)},
      pid          = {G:(DE-HGF)POF3-341},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25851096},
      doi          = {10.1038/ncomms7643},
      url          = {https://pub.dzne.de/record/141301},
}