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000141325 0247_ $$2doi$$a10.1083/jcb.200912082
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000141325 0247_ $$2ISSN$$a0095-9901
000141325 0247_ $$2ISSN$$a1540-8140
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000141325 037__ $$aDZNE-2020-07647
000141325 041__ $$aEnglish
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000141325 1001_ $$aFarhan, Hesso$$b0
000141325 245__ $$aMAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening.
000141325 260__ $$aNew York, NY$$bRockefeller Univ. Press$$c2010
000141325 264_1 $$2Crossref$$3online$$bRockefeller University Press$$c2010-06-14
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000141325 520__ $$aTo what extent the secretory pathway is regulated by cellular signaling is unknown. In this study, we used RNA interference to explore the function of human kinases and phosphatases in controlling the organization of and trafficking within the secretory pathway. We identified 122 kinases/phosphatases that affect endoplasmic reticulum (ER) export, ER exit sites (ERESs), and/or the Golgi apparatus. Numerous kinases/phosphatases regulate the number of ERESs and ER to Golgi protein trafficking. Among the pathways identified, the Raf-MEK (MAPK/ERK [extracellular signal-regulated kinase] kinase)-ERK cascade, including its regulatory proteins CNK1 (connector enhancer of the kinase suppressor of Ras-1) and neurofibromin, controls the number of ERESs via ERK2, which targets Sec16, a key regulator of ERESs and COPII (coat protein II) vesicle biogenesis. Our analysis reveals an unanticipated complexity of kinase/phosphatase-mediated regulation of the secretory pathway, uncovering a link between growth factor signaling and ER export.
000141325 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
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000141325 650_7 $$2NLM Chemicals$$aLMAN1 protein, human
000141325 650_7 $$2NLM Chemicals$$aMannose-Binding Lectins
000141325 650_7 $$2NLM Chemicals$$aMembrane Proteins
000141325 650_7 $$2NLM Chemicals$$aRNA, Small Interfering
000141325 650_7 $$2NLM Chemicals$$aVesicular Transport Proteins
000141325 650_7 $$0EC 2.7.-$$2NLM Chemicals$$aPhosphotransferases
000141325 650_7 $$0EC 2.7.11.24$$2NLM Chemicals$$aMitogen-Activated Protein Kinases
000141325 650_7 $$0EC 3.1.3.2$$2NLM Chemicals$$aPhosphoric Monoester Hydrolases
000141325 650_2 $$2MeSH$$aAnimals
000141325 650_2 $$2MeSH$$aCOP-Coated Vesicles: metabolism
000141325 650_2 $$2MeSH$$aDatabases, Factual
000141325 650_2 $$2MeSH$$aEndoplasmic Reticulum: metabolism
000141325 650_2 $$2MeSH$$aFluorescence Recovery After Photobleaching
000141325 650_2 $$2MeSH$$aGolgi Apparatus: metabolism
000141325 650_2 $$2MeSH$$aHeLa Cells
000141325 650_2 $$2MeSH$$aHumans
000141325 650_2 $$2MeSH$$aMAP Kinase Signaling System: physiology
000141325 650_2 $$2MeSH$$aMannose-Binding Lectins: genetics
000141325 650_2 $$2MeSH$$aMannose-Binding Lectins: metabolism
000141325 650_2 $$2MeSH$$aMembrane Proteins: genetics
000141325 650_2 $$2MeSH$$aMembrane Proteins: metabolism
000141325 650_2 $$2MeSH$$aMitogen-Activated Protein Kinases: genetics
000141325 650_2 $$2MeSH$$aMitogen-Activated Protein Kinases: metabolism
000141325 650_2 $$2MeSH$$aPhosphoric Monoester Hydrolases: metabolism
000141325 650_2 $$2MeSH$$aPhosphotransferases: metabolism
000141325 650_2 $$2MeSH$$aRNA Interference
000141325 650_2 $$2MeSH$$aRNA, Small Interfering: genetics
000141325 650_2 $$2MeSH$$aRNA, Small Interfering: metabolism
000141325 650_2 $$2MeSH$$aSecretory Pathway: physiology
000141325 650_2 $$2MeSH$$aVesicular Transport Proteins: genetics
000141325 650_2 $$2MeSH$$aVesicular Transport Proteins: metabolism
000141325 7001_ $$aWendeler, Markus W$$b1
000141325 7001_ $$aMitrovic, Sandra$$b2
000141325 7001_ $$0P:(DE-2719)2159508$$aFava, Eugenio$$b3$$udzne
000141325 7001_ $$aSilberberg, Yael$$b4
000141325 7001_ $$aSharan, Roded$$b5
000141325 7001_ $$aZerial, Marino$$b6
000141325 7001_ $$0P:(DE-HGF)0$$aHauri, Hans-Peter$$b7$$eCorresponding author
000141325 77318 $$2Crossref$$3journal-article$$a10.1083/jcb.200912082$$b : Rockefeller University Press, 2010-06-14$$n6$$p997-1011$$tThe Journal of Cell Biology$$v189$$x1540-8140$$y2010
000141325 773__ $$0PERI:(DE-600)1421310-2$$a10.1083/jcb.200912082$$gVol. 189, no. 6, p. 997 - 1011$$n6$$p997-1011$$q189:6<997 - 1011$$tThe journal of cell biology$$v189$$x1540-8140$$y2010
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000141325 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886346
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