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@ARTICLE{Farhan:141325,
      author       = {Farhan, Hesso and Wendeler, Markus W and Mitrovic, Sandra
                      and Fava, Eugenio and Silberberg, Yael and Sharan, Roded and
                      Zerial, Marino and Hauri, Hans-Peter},
      title        = {{MAPK} signaling to the early secretory pathway revealed by
                      kinase/phosphatase functional screening.},
      journal      = {The journal of cell biology},
      volume       = {189},
      number       = {6},
      issn         = {1540-8140},
      address      = {New York, NY},
      publisher    = {Rockefeller Univ. Press},
      reportid     = {DZNE-2020-07647},
      pages        = {997-1011},
      year         = {2010},
      abstract     = {To what extent the secretory pathway is regulated by
                      cellular signaling is unknown. In this study, we used RNA
                      interference to explore the function of human kinases and
                      phosphatases in controlling the organization of and
                      trafficking within the secretory pathway. We identified 122
                      kinases/phosphatases that affect endoplasmic reticulum (ER)
                      export, ER exit sites (ERESs), and/or the Golgi apparatus.
                      Numerous kinases/phosphatases regulate the number of ERESs
                      and ER to Golgi protein trafficking. Among the pathways
                      identified, the Raf-MEK (MAPK/ERK [extracellular
                      signal-regulated kinase] kinase)-ERK cascade, including its
                      regulatory proteins CNK1 (connector enhancer of the kinase
                      suppressor of Ras-1) and neurofibromin, controls the number
                      of ERESs via ERK2, which targets Sec16, a key regulator of
                      ERESs and COPII (coat protein II) vesicle biogenesis. Our
                      analysis reveals an unanticipated complexity of
                      kinase/phosphatase-mediated regulation of the secretory
                      pathway, uncovering a link between growth factor signaling
                      and ER export.},
      keywords     = {Animals / COP-Coated Vesicles: metabolism / Databases,
                      Factual / Endoplasmic Reticulum: metabolism / Fluorescence
                      Recovery After Photobleaching / Golgi Apparatus: metabolism
                      / HeLa Cells / Humans / MAP Kinase Signaling System:
                      physiology / Mannose-Binding Lectins: genetics /
                      Mannose-Binding Lectins: metabolism / Membrane Proteins:
                      genetics / Membrane Proteins: metabolism / Mitogen-Activated
                      Protein Kinases: genetics / Mitogen-Activated Protein
                      Kinases: metabolism / Phosphoric Monoester Hydrolases:
                      metabolism / Phosphotransferases: metabolism / RNA
                      Interference / RNA, Small Interfering: genetics / RNA, Small
                      Interfering: metabolism / Secretory Pathway: physiology /
                      Vesicular Transport Proteins: genetics / Vesicular Transport
                      Proteins: metabolism / LMAN1 protein, human (NLM Chemicals)
                      / Mannose-Binding Lectins (NLM Chemicals) / Membrane
                      Proteins (NLM Chemicals) / RNA, Small Interfering (NLM
                      Chemicals) / Vesicular Transport Proteins (NLM Chemicals) /
                      Phosphotransferases (NLM Chemicals) / Mitogen-Activated
                      Protein Kinases (NLM Chemicals) / Phosphoric Monoester
                      Hydrolases (NLM Chemicals)},
      cin          = {AG Fava 1},
      ddc          = {570},
      cid          = {I:(DE-2719)1013016},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:20548102},
      pmc          = {pmc:PMC2886346},
      doi          = {10.1083/jcb.200912082},
      url          = {https://pub.dzne.de/record/141325},
}