000141377 001__ 141377
000141377 005__ 20240321220941.0
000141377 0247_ $$2doi$$a10.1212/WNL.0000000000001012
000141377 0247_ $$2pmid$$apmid:25326098
000141377 0247_ $$2pmc$$apmc:PMC4248456
000141377 0247_ $$2ISSN$$a0028-3878
000141377 0247_ $$2ISSN$$a1526-632X
000141377 0247_ $$2altmetric$$aaltmetric:2788380
000141377 037__ $$aDZNE-2020-07699
000141377 041__ $$aEnglish
000141377 082__ $$a610
000141377 1001_ $$aTheuns, Jessie$$b0
000141377 245__ $$aGlobal investigation and meta-analysis of the C9orf72 (G4C2)n repeat in Parkinson disease.
000141377 260__ $$a[S.l.]$$bOvid$$c2014
000141377 264_1 $$2Crossref$$3online$$bOvid Technologies (Wolters Kluwer Health)$$c2014-10-17
000141377 264_1 $$2Crossref$$3print$$bOvid Technologies (Wolters Kluwer Health)$$c2014-11-18
000141377 3367_ $$2DRIVER$$aarticle
000141377 3367_ $$2DataCite$$aOutput Types/Journal article
000141377 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1596713943_18167
000141377 3367_ $$2BibTeX$$aARTICLE
000141377 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000141377 3367_ $$00$$2EndNote$$aJournal Article
000141377 520__ $$aThe objective of this study is to clarify the role of (G4C2)n expansions in the etiology of Parkinson disease (PD) in the worldwide multicenter Genetic Epidemiology of Parkinson's Disease (GEO-PD) cohort.C9orf72 (G4C2)n repeats were assessed in a GEO-PD cohort of 7,494 patients diagnosed with PD and 5,886 neurologically healthy control individuals ascertained in Europe, Asia, North America, and Australia.A pathogenic (G4C2)n>60 expansion was detected in only 4 patients with PD (4/7,232; 0.055%), all with a positive family history of neurodegenerative dementia, amyotrophic lateral sclerosis, or atypical parkinsonism, while no carriers were detected with typical sporadic or familial PD. Meta-analysis revealed a small increase in risk of PD with an increasing number of (G4C2)n repeats; however, we could not detect a robust association between the C9orf72 (G4C2)n repeat and PD, and the population attributable risk was low.Together, these findings indicate that expansions in C9orf72 do not have a major role in the pathogenesis of PD. Testing for C9orf72 repeat expansions should only be considered in patients with PD who have overt symptoms of frontotemporal lobar degeneration/amyotrophic lateral sclerosis or apparent family history of neurodegenerative dementia or motor neuron disease.
000141377 536__ $$0G:(DE-HGF)POF3-345$$a345 - Population Studies and Genetics (POF3-345)$$cPOF3-345$$fPOF III$$x0
000141377 588__ $$aDataset connected to CrossRef, PubMed,
000141377 650_7 $$2NLM Chemicals$$aC9orf72 Protein
000141377 650_7 $$2NLM Chemicals$$aC9orf72 protein, human
000141377 650_7 $$2NLM Chemicals$$aProteins
000141377 650_2 $$2MeSH$$aC9orf72 Protein
000141377 650_2 $$2MeSH$$aCohort Studies
000141377 650_2 $$2MeSH$$aDNA Repeat Expansion: genetics
000141377 650_2 $$2MeSH$$aFemale
000141377 650_2 $$2MeSH$$aHumans
000141377 650_2 $$2MeSH$$aInternationality
000141377 650_2 $$2MeSH$$aMale
000141377 650_2 $$2MeSH$$aMiddle Aged
000141377 650_2 $$2MeSH$$aParkinson Disease: diagnosis
000141377 650_2 $$2MeSH$$aParkinson Disease: epidemiology
000141377 650_2 $$2MeSH$$aParkinson Disease: genetics
000141377 650_2 $$2MeSH$$aProteins: genetics
000141377 7001_ $$aVerstraeten, Aline$$b1
000141377 7001_ $$aSleegers, Kristel$$b2
000141377 7001_ $$aWauters, Eline$$b3
000141377 7001_ $$aGijselinck, Ilse$$b4
000141377 7001_ $$aSmolders, Stefanie$$b5
000141377 7001_ $$aCrosiers, David$$b6
000141377 7001_ $$aCorsmit, Ellen$$b7
000141377 7001_ $$aElinck, Ellen$$b8
000141377 7001_ $$0P:(DE-2719)9000296$$aSharma, Manu$$b9$$udzne
000141377 7001_ $$0P:(DE-2719)2811170$$aKrüger, Rejko$$b10$$udzne
000141377 7001_ $$aLesage, Suzanne$$b11
000141377 7001_ $$aBrice, Alexis$$b12
000141377 7001_ $$aChung, Sun Ju$$b13
000141377 7001_ $$aKim, Mi-Jung$$b14
000141377 7001_ $$aKim, Young Jin$$b15
000141377 7001_ $$aRoss, Owen A$$b16
000141377 7001_ $$aWszolek, Zbigniew K$$b17
000141377 7001_ $$aRogaeva, Ekaterina$$b18
000141377 7001_ $$aXi, Zhengrui$$b19
000141377 7001_ $$aLang, Anthony E$$b20
000141377 7001_ $$aKlein, Christine$$b21
000141377 7001_ $$aWeissbach, Anne$$b22
000141377 7001_ $$aMellick, George D$$b23
000141377 7001_ $$aSilburn, Peter A$$b24
000141377 7001_ $$aHadjigeorgiou, Georgios M$$b25
000141377 7001_ $$aDardiotis, Efthimios$$b26
000141377 7001_ $$aHattori, Nobutaka$$b27
000141377 7001_ $$aOgaki, Kotaro$$b28
000141377 7001_ $$aTan, Eng-King$$b29
000141377 7001_ $$aZhao, Yi$$b30
000141377 7001_ $$aAasly, Jan$$b31
000141377 7001_ $$aValente, Enza Maria$$b32
000141377 7001_ $$aPetrucci, Simona$$b33
000141377 7001_ $$aAnnesi, Grazia$$b34
000141377 7001_ $$aQuattrone, Aldo$$b35
000141377 7001_ $$aFerrarese, Carlo$$b36
000141377 7001_ $$aBrighina, Laura$$b37
000141377 7001_ $$aDeutschländer, Angela$$b38
000141377 7001_ $$aPuschmann, Andreas$$b39
000141377 7001_ $$aNilsson, Christer$$b40
000141377 7001_ $$aGarraux, Gaëtan$$b41
000141377 7001_ $$aLeDoux, Mark S$$b42
000141377 7001_ $$aPfeiffer, Ronald F$$b43
000141377 7001_ $$aBoczarska-Jedynak, Magdalena$$b44
000141377 7001_ $$aOpala, Grzegorz$$b45
000141377 7001_ $$aMaraganore, Demetrius M$$b46
000141377 7001_ $$aEngelborghs, Sebastiaan$$b47
000141377 7001_ $$aDe Deyn, Peter Paul$$b48
000141377 7001_ $$aCras, Patrick$$b49
000141377 7001_ $$aCruts, Marc$$b50
000141377 7001_ $$0P:(DE-HGF)0$$aVan Broeckhoven, Christine$$b51$$eCorresponding author
000141377 7001_ $$aConsortium, GEO-PD$$b52
000141377 7001_ $$aMaraganore, Demetrius M$$b53
000141377 7001_ $$aFarrer, Matthew J$$b54
000141377 7001_ $$aAasly, Jan O$$b55
000141377 7001_ $$aElbaz, Alexis$$b56
000141377 7001_ $$aIoannidis, John P$$b57
000141377 7001_ $$aAnnesi, Grazie$$b58
000141377 7001_ $$aValente, Enza Maria$$b59
000141377 7001_ $$aBozi, Maria$$b60
000141377 7001_ $$aBrice, Alexis$$b61
000141377 7001_ $$aCurie, Marie$$b62
000141377 7001_ $$aCarmine-Belin, Andrea$$b63
000141377 7001_ $$aCarr, Jonathan$$b64
000141377 7001_ $$aCarroll, Camille$$b65
000141377 7001_ $$aChen, Sheng-Di$$b66
000141377 7001_ $$aChung, Sun Ju$$b67
000141377 7001_ $$aCosentino, Carlos$$b68
000141377 7001_ $$aCresswell, Silke$$b69
000141377 7001_ $$aDeutschlaender, Angela$$b70
000141377 7001_ $$aFerrarese, Carlo$$b71
000141377 7001_ $$aForoud, Tatiana$$b72
000141377 7001_ $$aGarraux, Gaëtan$$b73
000141377 7001_ $$aGoldwurm, Stefano$$b74
000141377 7001_ $$aHadjigeorgiou, George$$b75
000141377 7001_ $$aChartier-Harlin, Marie-Christine$$b76
000141377 7001_ $$aHassan, Anhar$$b77
000141377 7001_ $$aHattori, Nobutaka$$b78
000141377 7001_ $$aHentati, Faycal$$b79
000141377 7001_ $$aJeon, Beom Seok$$b80
000141377 7001_ $$aKawakami, Hideshi$$b81
000141377 7001_ $$aKim, Yun Joong$$b82
000141377 7001_ $$aKishore, Asha$$b83
000141377 7001_ $$aKlein, Christine$$b84
000141377 7001_ $$aKoks, Sulev$$b85
000141377 7001_ $$aKrainc, Dimitri$$b86
000141377 7001_ $$aKrygowska-Wajs, Anna$$b87
000141377 7001_ $$aLin, Juei-Jueng$$b88
000141377 7001_ $$aLynch, Tim$$b89
000141377 7001_ $$aMaraganore, Demetrius M$$b90
000141377 7001_ $$aMellick, George$$b91
000141377 7001_ $$aMorrison, Karen E$$b92
000141377 7001_ $$aMunhoz, Renato P$$b93
000141377 7001_ $$aOpala, Grzegorz$$b94
000141377 7001_ $$aPastor, Pao$$b95
000141377 7001_ $$aPayami, Haydeh$$b96
000141377 7001_ $$aPchelina, Sofya N$$b97
000141377 7001_ $$aPetersburg, Saint$$b98
000141377 7001_ $$aPetersen, Maria Skaalum$$b99
000141377 7001_ $$aPuschmann, Andrea$$b100
000141377 7001_ $$aRitz, Beate$$b101
000141377 7001_ $$aRogaeva, Ekaterina$$b102
000141377 7001_ $$aSazci, Ali$$b103
000141377 7001_ $$aSlawek, Jaroslaw$$b104
000141377 7001_ $$aStefanis, Leonidas$$b105
000141377 7001_ $$aTan, Eng-King$$b106
000141377 7001_ $$aToda, Tatsushi$$b107
000141377 7001_ $$aToft, Matthias$$b108
000141377 7001_ $$aVan Broeckhoven, Christine$$b109
000141377 7001_ $$aWirdefeldt, Karin$$b110
000141377 7001_ $$aWoitalla, Dirk$$b111
000141377 7001_ $$aWszolek, Zbigniew K$$b112
000141377 7001_ $$aZimprich, Alexander$$b113
000141377 77318 $$2Crossref$$3journal-article$$a10.1212/wnl.0000000000001012$$b : Ovid Technologies (Wolters Kluwer Health), 2014-10-17$$n21$$p1906-1913$$tNeurology$$v83$$x0028-3878$$y2014
000141377 773__ $$0PERI:(DE-600)1491874-2$$a10.1212/WNL.0000000000001012$$gVol. 83, no. 21, p. 1906 - 1913$$n21$$p1906-1913$$q83:21<1906 - 1913$$tNeurology$$v83$$x0028-3878$$y2014
000141377 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248456
000141377 909CO $$ooai:pub.dzne.de:141377$$pVDB
000141377 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000296$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b9$$kDZNE
000141377 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811170$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b10$$kDZNE
000141377 9131_ $$0G:(DE-HGF)POF3-345$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$aDE-HGF$$bForschungsbereich Gesundheit$$lErkrankungen des Nervensystems$$vPopulation Studies and Genetics$$x0
000141377 9141_ $$y2014
000141377 915__ $$0StatID:(DE-HGF)0410$$2StatID$$aAllianz-Lizenz
000141377 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNEUROLOGY : 2017
000141377 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000141377 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000141377 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000141377 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central
000141377 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000141377 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000141377 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000141377 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000141377 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine
000141377 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000141377 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000141377 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bNEUROLOGY : 2017
000141377 9201_ $$0I:(DE-2719)5000057$$kExt HIH$$lExt Hertie-Institut für klinische Hirnforschung$$x0
000141377 9201_ $$0I:(DE-2719)1210000$$kAG Gasser 1$$lParkinson Genetics$$x1
000141377 980__ $$ajournal
000141377 980__ $$aVDB
000141377 980__ $$aI:(DE-2719)5000057
000141377 980__ $$aI:(DE-2719)1210000
000141377 980__ $$aUNRESTRICTED