guest ::
| Home > Publications Database > Surveillance-activated defenses block the ROS-induced mitochondrial unfolded protein response. > print |
| Home > Publications Database > Surveillance-activated defenses block the ROS-induced mitochondrial unfolded protein response. > print |
| 001 | 141390 | ||
| 005 | 20240427115948.0 | ||
| 024 | 7 | _ | |a 10.1371/journal.pgen.1003346 |2 doi |
| 024 | 7 | _ | |a pmid:23516373 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC3597513 |2 pmc |
| 024 | 7 | _ | |a 1553-7390 |2 ISSN |
| 024 | 7 | _ | |a 1553-7404 |2 ISSN |
| 024 | 7 | _ | |a altmetric:1302178 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-07712 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Runkel, Eva D |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Surveillance-activated defenses block the ROS-induced mitochondrial unfolded protein response. |
| 260 | _ | _ | |a San Francisco, Calif. |c 2013 |b Public Library of Science |
| 264 | _ | 1 | |3 online |2 Crossref |b Public Library of Science (PLoS) |c 2013-03-14 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1714134277_27683 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Disturbance of cellular functions results in the activation of stress-signaling pathways that aim at restoring homeostasis. We performed a genome-wide screen to identify components of the signal transduction of the mitochondrial unfolded protein response (UPR(mt)) to a nuclear chaperone promoter. We used the ROS generating complex I inhibitor paraquat to induce the UPR(mt), and we employed RNAi exposure post-embryonically to allow testing genes whose knockdown results in embryonic lethality. We identified 54 novel regulators of the ROS-induced UPR(mt). Activation of the UPR(mt), but not of other stress-signaling pathways, failed when homeostasis of basic cellular mechanisms such as translation and protein transport were impaired. These mechanisms are monitored by a recently discovered surveillance system that interprets interruption of these processes as pathogen attack and depends on signaling through the JNK-like MAP-kinase KGB-1. Mutation of kgb-1 abrogated the inhibition of ROS-induced UPR(mt), suggesting that surveillance-activated defenses specifically inhibit the UPR(mt) but do not compromise activation of the heat shock response, the UPR of the endoplasmic reticulum, or the SKN-1/Nrf2 mediated response to cytosolic stress. In addition, we identified PIFK-1, the orthologue of the Drosophila PI 4-kinase four wheel drive (FWD), and found that it is the only known factor so far that is essential for the unfolded protein responses of both mitochondria and endoplasmic reticulum. This suggests that both UPRs may share a common membrane associated mechanism. |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 0 |
| 542 | _ | _ | |i 2013-03-14 |2 Crossref |u http://creativecommons.org/licenses/by/4.0/ |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a ATFS-1 protein, C elegans |2 NLM Chemicals |
| 650 | _ | 7 | |a ATP-Binding Cassette Transporters |2 NLM Chemicals |
| 650 | _ | 7 | |a Caenorhabditis elegans Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a HAF-1 protein, C elegans |2 NLM Chemicals |
| 650 | _ | 7 | |a Molecular Chaperones |2 NLM Chemicals |
| 650 | _ | 7 | |a Reactive Oxygen Species |2 NLM Chemicals |
| 650 | _ | 7 | |a Transcription Factors |2 NLM Chemicals |
| 650 | _ | 7 | |a JNK Mitogen-Activated Protein Kinases |0 EC 2.7.11.24 |2 NLM Chemicals |
| 650 | _ | 7 | |a KGB-1 protein, C elegans |0 EC 2.7.11.24 |2 NLM Chemicals |
| 650 | _ | 7 | |a Paraquat |0 PLG39H7695 |2 NLM Chemicals |
| 650 | _ | 2 | |a ATP-Binding Cassette Transporters: metabolism |2 MeSH |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Caenorhabditis elegans: genetics |2 MeSH |
| 650 | _ | 2 | |a Caenorhabditis elegans: growth & development |2 MeSH |
| 650 | _ | 2 | |a Caenorhabditis elegans: metabolism |2 MeSH |
| 650 | _ | 2 | |a Caenorhabditis elegans Proteins: genetics |2 MeSH |
| 650 | _ | 2 | |a Caenorhabditis elegans Proteins: metabolism |2 MeSH |
| 650 | _ | 2 | |a Cell Nucleus: genetics |2 MeSH |
| 650 | _ | 2 | |a Cell Nucleus: metabolism |2 MeSH |
| 650 | _ | 2 | |a Endoplasmic Reticulum: genetics |2 MeSH |
| 650 | _ | 2 | |a Endoplasmic Reticulum: metabolism |2 MeSH |
| 650 | _ | 2 | |a JNK Mitogen-Activated Protein Kinases: genetics |2 MeSH |
| 650 | _ | 2 | |a JNK Mitogen-Activated Protein Kinases: metabolism |2 MeSH |
| 650 | _ | 2 | |a Mitochondria: drug effects |2 MeSH |
| 650 | _ | 2 | |a Mitochondria: metabolism |2 MeSH |
| 650 | _ | 2 | |a Molecular Chaperones |2 MeSH |
| 650 | _ | 2 | |a Paraquat: pharmacology |2 MeSH |
| 650 | _ | 2 | |a Phosphorylation |2 MeSH |
| 650 | _ | 2 | |a Protein Folding |2 MeSH |
| 650 | _ | 2 | |a Reactive Oxygen Species: metabolism |2 MeSH |
| 650 | _ | 2 | |a Reactive Oxygen Species: toxicity |2 MeSH |
| 650 | _ | 2 | |a Signal Transduction: drug effects |2 MeSH |
| 650 | _ | 2 | |a Transcription Factors: metabolism |2 MeSH |
| 650 | _ | 2 | |a Unfolded Protein Response: drug effects |2 MeSH |
| 700 | 1 | _ | |a Liu, Shu |0 P:(DE-2719)2810461 |b 1 |u dzne |
| 700 | 1 | _ | |a Baumeister, Ralf |0 P:(DE-HGF)0 |b 2 |e Corresponding author |
| 700 | 1 | _ | |a Schulze, Ekkehard |0 P:(DE-HGF)0 |b 3 |
| 773 | 1 | 8 | |a 10.1371/journal.pgen.1003346 |b : Public Library of Science (PLoS), 2013-03-14 |n 3 |p e1003346 |3 journal-article |2 Crossref |t PLoS Genetics |v 9 |y 2013 |x 1553-7404 |
| 773 | _ | _ | |a 10.1371/journal.pgen.1003346 |g Vol. 9, no. 3, p. e1003346 - |0 PERI:(DE-600)2186725-2 |n 3 |q 9:3 |t PLoS Genetics |v 9 |y 2013 |x 1553-7404 |
| 856 | 4 | _ | |u https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1003346 |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597513 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/141390/files/DZNE-2020-07712.pdf |y OpenAccess |
| 856 | 4 | _ | |u https://pub.dzne.de/record/141390/files/DZNE-2020-07712.pdf?subformat=pdfa |x pdfa |y OpenAccess |
| 909 | C | O | |o oai:pub.dzne.de:141390 |p openaire |p open_access |p VDB |p driver |p dnbdelivery |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 1 |6 P:(DE-2719)2810461 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-342 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Disease Mechanisms and Model Systems |x 0 |
| 914 | 1 | _ | |y 2013 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a Creative Commons Attribution CC BY (No Version) |0 LIC:(DE-HGF)CCBYNV |2 V:(DE-HGF) |b DOAJ |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1040 |2 StatID |b Zoological Record |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b PLOS GENET : 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0501 |2 StatID |b DOAJ Seal |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0500 |2 StatID |b DOAJ |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |
| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b PLOS GENET : 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0320 |2 StatID |b PubMed Central |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 920 | 1 | _ | |0 I:(DE-2719)1013004 |k AG Vorberg |l Prion Cell Biology |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a I:(DE-2719)1013004 |
| 980 | 1 | _ | |a FullTexts |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.mad.2009.02.004 |2 Crossref |o 10.1016/j.mad.2009.02.004 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1371/journal.ppat.1000689 |2 Crossref |o 10.1371/journal.ppat.1000689 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.cell.2012.02.050 |2 Crossref |o 10.1016/j.cell.2012.02.050 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.ydbio.2008.02.060 |2 Crossref |o 10.1016/j.ydbio.2008.02.060 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1146/annurev.ge.22.120188.003215 |2 Crossref |o 10.1146/annurev.ge.22.120188.003215 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S0955-0674(00)00219-2 |2 Crossref |o 10.1016/S0955-0674(00)00219-2 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1126/science.1209038 |2 Crossref |o 10.1126/science.1209038 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/0092-8674(91)90452-5 |2 Crossref |o 10.1016/0092-8674(91)90452-5 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1379/1466-1268(1999)004<0235:DOOSRI>2.3.CO;2 |2 Crossref |o 10.1379/1466-1268(1999)004<0235:DOOSRI>2.3.CO;2 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S0076-6879(02)53072-X |2 Crossref |o 10.1016/S0076-6879(02)53072-X |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1139/o83-064 |2 Crossref |o 10.1139/o83-064 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.7164/antibiotics.24.215 |2 Crossref |o 10.7164/antibiotics.24.215 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S0092-8674(01)00612-2 |2 Crossref |o 10.1016/S0092-8674(01)00612-2 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.cell.2008.01.030 |2 Crossref |o 10.1016/j.cell.2008.01.030 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ng1723 |2 Crossref |o 10.1038/ng1723 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1126/science.1139952 |2 Crossref |o 10.1126/science.1139952 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/msb.2010.54 |2 Crossref |o 10.1038/msb.2010.54 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1111/j.1474-9726.2009.00501.x |2 Crossref |o 10.1111/j.1474-9726.2009.00501.x |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.M110.146274 |2 Crossref |o 10.1074/jbc.M110.146274 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1371/journal.pgen.1001048 |2 Crossref |o 10.1371/journal.pgen.1001048 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1097/MCO.0b013e32834136f2 |2 Crossref |o 10.1097/MCO.0b013e32834136f2 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1242/jcs.01275 |2 Crossref |o 10.1242/jcs.01275 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1534/genetics.106.061580 |2 Crossref |o 10.1534/genetics.106.061580 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.devcel.2007.07.016 |2 Crossref |o 10.1016/j.devcel.2007.07.016 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.molcel.2010.01.015 |2 Crossref |o 10.1016/j.molcel.2010.01.015 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.bbamcr.2012.02.019 |2 Crossref |o 10.1016/j.bbamcr.2012.02.019 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1242/jcs.075119 |2 Crossref |o 10.1242/jcs.075119 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.cell.2010.12.016 |2 Crossref |o 10.1016/j.cell.2010.12.016 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1126/science.1223560 |2 Crossref |o 10.1126/science.1223560 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1146/annurev.bb.21.060192.001453 |2 Crossref |o 10.1146/annurev.bb.21.060192.001453 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.tcb.2007.11.003 |2 Crossref |o 10.1016/j.tcb.2007.11.003 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1371/journal.pgen.1002760 |2 Crossref |o 10.1371/journal.pgen.1002760 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1177/039463201102400205 |2 Crossref |o 10.1177/039463201102400205 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1371/journal.pbio.1000556 |2 Crossref |o 10.1371/journal.pbio.1000556 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.M708597200 |2 Crossref |o 10.1074/jbc.M708597200 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S0005-2728(98)00029-2 |2 Crossref |o 10.1016/S0005-2728(98)00029-2 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1096/fasebj.13.11.1385 |2 Crossref |o 10.1096/fasebj.13.11.1385 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/sj.emboj.7600599 |2 Crossref |o 10.1038/sj.emboj.7600599 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S1534-5807(01)00071-5 |2 Crossref |o 10.1016/S1534-5807(01)00071-5 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.cub.2010.10.057 |2 Crossref |o 10.1016/j.cub.2010.10.057 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.cmet.2007.08.011 |2 Crossref |o 10.1016/j.cmet.2007.08.011 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/toxsci/kfp223 |2 Crossref |o 10.1093/toxsci/kfp223 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1265/ehpm.2002.89 |2 Crossref |o 10.1265/ehpm.2002.89 |
| 999 | C | 5 | |y 1993 |2 Crossref |o T Fukushima 1993 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.M109.033431 |2 Crossref |o 10.1074/jbc.M109.033431 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1534/genetics.107.080788 |2 Crossref |o 10.1534/genetics.107.080788 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1042/BJ20070521 |2 Crossref |o 10.1042/BJ20070521 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1021/tx00017a004 |2 Crossref |o 10.1021/tx00017a004 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S0891-5849(00)00380-4 |2 Crossref |o 10.1016/S0891-5849(00)00380-4 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/0891-5849(89)90066-X |2 Crossref |o 10.1016/0891-5849(89)90066-X |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/nar/26.7.1621 |2 Crossref |o 10.1093/nar/26.7.1621 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1101/gad.1107803 |2 Crossref |o 10.1101/gad.1107803 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.cell.2006.03.046 |2 Crossref |o 10.1016/j.cell.2006.03.046 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1101/gr.2505604 |2 Crossref |o 10.1101/gr.2505604 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nprot.2008.211 |2 Crossref |o 10.1038/nprot.2008.211 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.270.24.14666 |2 Crossref |o 10.1074/jbc.270.24.14666 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.ydbio.2010.08.020 |2 Crossref |o 10.1016/j.ydbio.2010.08.020 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/toxsci/kfm276 |2 Crossref |o 10.1093/toxsci/kfm276 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/s00425-012-1696-9 |2 Crossref |o 10.1007/s00425-012-1696-9 |
| 999 | C | 5 | |y 2012 |2 Crossref |o ME Perez-Perez 2012 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.pbi.2011.07.014 |2 Crossref |o 10.1016/j.pbi.2011.07.014 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1017/S1462399411002079 |2 Crossref |o 10.1017/S1462399411002079 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.2174/156802611796235107 |2 Crossref |o 10.2174/156802611796235107 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1083/jcb.200908107 |2 Crossref |o 10.1083/jcb.200908107 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.tcb.2010.10.002 |2 Crossref |o 10.1016/j.tcb.2010.10.002 |
| 999 | C | 5 | |y 1974 |2 Crossref |o S Brenner 1974 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nature05603 |2 Crossref |o 10.1038/nature05603 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.4161/cc.6.10.4230 |2 Crossref |o 10.4161/cc.6.10.4230 |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|