TY  - JOUR
AU  - de Kovel, Carolien G F
AU  - Aftanas, Lyubomir
AU  - Aleman, André
AU  - Alexander-Bloch, Aaron F
AU  - Baune, Bernhard T
AU  - Brack, Ivan
AU  - Bülow, Robin
AU  - Busatto Filho, Geraldo
AU  - Carballedo, Angela
AU  - Connolly, Colm G
AU  - Cullen, Kathryn R
AU  - Dannlowski, Udo
AU  - Davey, Christopher G
AU  - Dima, Danai
AU  - Dohm, Katharina
AU  - Erwin-Grabner, Tracy
AU  - Frodl, Thomas
AU  - Fu, Cynthia H Y
AU  - Hall, Geoffrey B
AU  - Glahn, David C
AU  - Godlewska, Beata
AU  - Gotlib, Ian H
AU  - Goya-Maldonado, Roberto
AU  - Grabe, Hans Jörgen
AU  - Groenewold, Nynke A
AU  - Grotegerd, Dominik
AU  - Gruber, Oliver
AU  - Harris, Mathew A
AU  - Harrison, Ben J
AU  - Hatton, Sean N
AU  - Hickie, Ian B
AU  - Ho, Tiffany C
AU  - Jahanshad, Neda
AU  - Kircher, Tilo
AU  - Krämer, Bernd
AU  - Krug, Axel
AU  - Lagopoulos, Jim
AU  - Leehr, Elisabeth J
AU  - Li, Meng
AU  - MacMaster, Frank P
AU  - MacQueen, Glenda
AU  - McIntosh, Andrew M
AU  - McLellan, Quinn
AU  - Medland, Sarah E
AU  - Mueller, Bryon A
AU  - Nenadic, Igor
AU  - Osipov, Evgeny
AU  - Papmeyer, Martina
AU  - Portella, Maria J
AU  - Reneman, Liesbeth
AU  - Rosa, Pedro G P
AU  - Sacchet, Matthew D
AU  - Schnell, Knut
AU  - Schrantee, Anouk
AU  - Sim, Kang
AU  - Simulionyte, Egle
AU  - Sindermann, Lisa
AU  - Singh, Aditya
AU  - Stein, Dan J
AU  - Ubani, Benjamin N
AU  - Van der Wee, Nic J A
AU  - Van der Werff, Steven J A
AU  - Veer, Ilya M
AU  - Vives-Gilabert, Yolanda
AU  - Völzke, Henry
AU  - Walter, Henrik
AU  - Walter, Martin
AU  - Schreiner, Melinda Westlund
AU  - Whalley, Heather
AU  - Winter, Nils
AU  - Wittfeld, Katharina
AU  - Yang, Tony T
AU  - Yüksel, Dilara
AU  - Zaremba, Dario
AU  - Thompson, Paul M
AU  - Veltman, Dick J
AU  - Schmaal, Lianne
AU  - Francks, Clyde
TI  - No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis.
JO  - The American journal of psychiatry
VL  - 176
IS  - 12
SN  - 0002-953X
CY  - Stanford, Calif.
PB  - HighWire Press
M1  - DZNE-2020-07831
SP  - 1039-1049
PY  - 2019
AB  - Asymmetry is a subtle but pervasive aspect of the human brain, and it may be altered in several psychiatric conditions. MRI studies have shown subtle differences of brain anatomy between people with major depressive disorder and healthy control subjects, but few studies have specifically examined brain anatomical asymmetry in relation to this disorder, and results from those studies have remained inconclusive. At the functional level, some electroencephalography studies have indicated left fronto-cortical hypoactivity and right parietal hypoactivity in depressive disorders, so aspects of lateralized anatomy may also be affected. The authors used pooled individual-level data from data sets collected around the world to investigate differences in laterality in measures of cortical thickness, cortical surface area, and subcortical volume between individuals with major depression and healthy control subjects.The authors investigated differences in the laterality of thickness and surface area measures of 34 cerebral cortical regions in 2,256 individuals with major depression and 3,504 control subjects from 31 separate data sets, and they investigated volume asymmetries of eight subcortical structures in 2,540 individuals with major depression and 4,230 control subjects from 32 data sets. T1-weighted MRI data were processed with a single protocol using FreeSurfer and the Desikan-Killiany atlas. The large sample size provided 80
KW  - Adult
KW  - Brain: anatomy & histology
KW  - Case-Control Studies
KW  - Databases, Factual: statistics & numerical data
KW  - Depressive Disorder, Major: pathology
KW  - Dominance, Cerebral
KW  - Female
KW  - Humans
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Meta-Analysis as Topic
KW  - Neuroimaging
KW  - Young Adult
LB  - PUB:(DE-HGF)16
C6  - pmid:31352813
DO  - DOI:10.1176/appi.ajp.2019.18101144
UR  - https://pub.dzne.de/record/141507
ER  -