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@ARTICLE{deKovel:141507,
      author       = {de Kovel, Carolien G F and Aftanas, Lyubomir and Aleman,
                      André and Alexander-Bloch, Aaron F and Baune, Bernhard T
                      and Brack, Ivan and Bülow, Robin and Busatto Filho, Geraldo
                      and Carballedo, Angela and Connolly, Colm G and Cullen,
                      Kathryn R and Dannlowski, Udo and Davey, Christopher G and
                      Dima, Danai and Dohm, Katharina and Erwin-Grabner, Tracy and
                      Frodl, Thomas and Fu, Cynthia H Y and Hall, Geoffrey B and
                      Glahn, David C and Godlewska, Beata and Gotlib, Ian H and
                      Goya-Maldonado, Roberto and Grabe, Hans Jörgen and
                      Groenewold, Nynke A and Grotegerd, Dominik and Gruber,
                      Oliver and Harris, Mathew A and Harrison, Ben J and Hatton,
                      Sean N and Hickie, Ian B and Ho, Tiffany C and Jahanshad,
                      Neda and Kircher, Tilo and Krämer, Bernd and Krug, Axel and
                      Lagopoulos, Jim and Leehr, Elisabeth J and Li, Meng and
                      MacMaster, Frank P and MacQueen, Glenda and McIntosh, Andrew
                      M and McLellan, Quinn and Medland, Sarah E and Mueller,
                      Bryon A and Nenadic, Igor and Osipov, Evgeny and Papmeyer,
                      Martina and Portella, Maria J and Reneman, Liesbeth and
                      Rosa, Pedro G P and Sacchet, Matthew D and Schnell, Knut and
                      Schrantee, Anouk and Sim, Kang and Simulionyte, Egle and
                      Sindermann, Lisa and Singh, Aditya and Stein, Dan J and
                      Ubani, Benjamin N and Van der Wee, Nic J A and Van der
                      Werff, Steven J A and Veer, Ilya M and Vives-Gilabert,
                      Yolanda and Völzke, Henry and Walter, Henrik and Walter,
                      Martin and Schreiner, Melinda Westlund and Whalley, Heather
                      and Winter, Nils and Wittfeld, Katharina and Yang, Tony T
                      and Yüksel, Dilara and Zaremba, Dario and Thompson, Paul M
                      and Veltman, Dick J and Schmaal, Lianne and Francks, Clyde},
      title        = {{N}o {A}lterations of {B}rain {S}tructural {A}symmetry in
                      {M}ajor {D}epressive {D}isorder: {A}n {ENIGMA} {C}onsortium
                      {A}nalysis.},
      journal      = {The American journal of psychiatry},
      volume       = {176},
      number       = {12},
      issn         = {0002-953X},
      address      = {Stanford, Calif.},
      publisher    = {HighWire Press},
      reportid     = {DZNE-2020-07831},
      pages        = {1039-1049},
      year         = {2019},
      abstract     = {Asymmetry is a subtle but pervasive aspect of the human
                      brain, and it may be altered in several psychiatric
                      conditions. MRI studies have shown subtle differences of
                      brain anatomy between people with major depressive disorder
                      and healthy control subjects, but few studies have
                      specifically examined brain anatomical asymmetry in relation
                      to this disorder, and results from those studies have
                      remained inconclusive. At the functional level, some
                      electroencephalography studies have indicated left
                      fronto-cortical hypoactivity and right parietal hypoactivity
                      in depressive disorders, so aspects of lateralized anatomy
                      may also be affected. The authors used pooled
                      individual-level data from data sets collected around the
                      world to investigate differences in laterality in measures
                      of cortical thickness, cortical surface area, and
                      subcortical volume between individuals with major depression
                      and healthy control subjects.The authors investigated
                      differences in the laterality of thickness and surface area
                      measures of 34 cerebral cortical regions in 2,256
                      individuals with major depression and 3,504 control subjects
                      from 31 separate data sets, and they investigated volume
                      asymmetries of eight subcortical structures in 2,540
                      individuals with major depression and 4,230 control subjects
                      from 32 data sets. T1-weighted MRI data were processed with
                      a single protocol using FreeSurfer and the Desikan-Killiany
                      atlas. The large sample size provided $80\%$ power to detect
                      effects of the order of Cohen's d=0.1.The largest effect
                      size (Cohen's d) of major depression diagnosis was 0.085 for
                      the thickness asymmetry of the superior temporal cortex,
                      which was not significant after adjustment for multiple
                      testing. Asymmetry measures were not significantly
                      associated with medication use, acute compared with remitted
                      status, first episode compared with recurrent status, or age
                      at onset.Altered brain macro-anatomical asymmetry may be of
                      little relevance to major depression etiology in most
                      cases.},
      keywords     = {Adult / Brain: anatomy $\&$ histology / Case-Control
                      Studies / Databases, Factual: statistics $\&$ numerical data
                      / Depressive Disorder, Major: pathology / Dominance,
                      Cerebral / Female / Humans / Magnetic Resonance Imaging /
                      Male / Meta-Analysis as Topic / Neuroimaging / Young Adult},
      cin          = {AG Grabe},
      ddc          = {610},
      cid          = {I:(DE-2719)5000001},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31352813},
      doi          = {10.1176/appi.ajp.2019.18101144},
      url          = {https://pub.dzne.de/record/141507},
}