%0 Journal Article
%A Löhle, Matthias
%A Hermann, Wiebke
%A Hausbrand, Denise
%A Wolz, Martin
%A Mende, Julia
%A Beuthien-Baumann, Bettina
%A Oehme, Liane
%A van den Hoff, Jörg
%A Kotzerke, Jörg
%A Reichmann, Heinz
%A Hermann, Andreas
%A Storch, Alexander
%T Putaminal Dopamine Turnover in de novo Parkinson's Disease Predicts Later Neuropsychiatric Fluctuations but Not Other Major Health Outcomes.
%J Journal of Parkinson's Disease
%V 9
%N 4
%@ 1877-7171
%C Amsterdam
%I IOS Press
%M DZNE-2020-07837
%P 693-704
%D 2019
%X To investigate the predictive value of striatal dopamine turnover in patients with de novo Parkinson's disease (PD) for later occurrence of major non-motor health outcomes.This retrospective, observer-blinded cohort study followed up 29 patients with de novo PD for a median of 10.7 years, who completed 18Fluorodopa PET imaging to measure striatal effective distribution volume ratio (EDVR, inverse of dopamine turnover) prior to antiparkinsonian treatment. Outcomes were assessed with a battery of non-motor, health-related quality-of-life and non-motor fluctuation (WOQ-19) measures and survival.During follow-up, 52
%K Aged
%K Caudate Nucleus: diagnostic imaging
%K Caudate Nucleus: metabolism
%K Dopamine: metabolism
%K Female
%K Fluorodeoxyglucose F18
%K Humans
%K Male
%K Neuropsychological Tests
%K Parkinson Disease: diagnostic imaging
%K Parkinson Disease: metabolism
%K Parkinson Disease: psychology
%K Positron-Emission Tomography
%K Putamen: diagnostic imaging
%K Putamen: metabolism
%K Quality of Life
%K Retrospective Studies
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31381528
%R 10.3233/JPD-191672
%U https://pub.dzne.de/record/141513