TY  - JOUR
AU  - Löhle, Matthias
AU  - Hermann, Wiebke
AU  - Hausbrand, Denise
AU  - Wolz, Martin
AU  - Mende, Julia
AU  - Beuthien-Baumann, Bettina
AU  - Oehme, Liane
AU  - van den Hoff, Jörg
AU  - Kotzerke, Jörg
AU  - Reichmann, Heinz
AU  - Hermann, Andreas
AU  - Storch, Alexander
TI  - Putaminal Dopamine Turnover in de novo Parkinson's Disease Predicts Later Neuropsychiatric Fluctuations but Not Other Major Health Outcomes.
JO  - Journal of Parkinson's Disease
VL  - 9
IS  - 4
SN  - 1877-7171
CY  - Amsterdam
PB  - IOS Press
M1  - DZNE-2020-07837
SP  - 693-704
PY  - 2019
AB  - To investigate the predictive value of striatal dopamine turnover in patients with de novo Parkinson's disease (PD) for later occurrence of major non-motor health outcomes.This retrospective, observer-blinded cohort study followed up 29 patients with de novo PD for a median of 10.7 years, who completed 18Fluorodopa PET imaging to measure striatal effective distribution volume ratio (EDVR, inverse of dopamine turnover) prior to antiparkinsonian treatment. Outcomes were assessed with a battery of non-motor, health-related quality-of-life and non-motor fluctuation (WOQ-19) measures and survival.During follow-up, 52
KW  - Aged
KW  - Caudate Nucleus: diagnostic imaging
KW  - Caudate Nucleus: metabolism
KW  - Dopamine: metabolism
KW  - Female
KW  - Fluorodeoxyglucose F18
KW  - Humans
KW  - Male
KW  - Neuropsychological Tests
KW  - Parkinson Disease: diagnostic imaging
KW  - Parkinson Disease: metabolism
KW  - Parkinson Disease: psychology
KW  - Positron-Emission Tomography
KW  - Putamen: diagnostic imaging
KW  - Putamen: metabolism
KW  - Quality of Life
KW  - Retrospective Studies
LB  - PUB:(DE-HGF)16
C6  - pmid:31381528
DO  - DOI:10.3233/JPD-191672
UR  - https://pub.dzne.de/record/141513
ER  -