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@ARTICLE{Lhle:141513,
      author       = {Löhle, Matthias and Hermann, Wiebke and Hausbrand, Denise
                      and Wolz, Martin and Mende, Julia and Beuthien-Baumann,
                      Bettina and Oehme, Liane and van den Hoff, Jörg and
                      Kotzerke, Jörg and Reichmann, Heinz and Hermann, Andreas
                      and Storch, Alexander},
      title        = {{P}utaminal {D}opamine {T}urnover in de novo {P}arkinson's
                      {D}isease {P}redicts {L}ater {N}europsychiatric
                      {F}luctuations but {N}ot {O}ther {M}ajor {H}ealth
                      {O}utcomes.},
      journal      = {Journal of Parkinson's Disease},
      volume       = {9},
      number       = {4},
      issn         = {1877-7171},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {DZNE-2020-07837},
      pages        = {693-704},
      year         = {2019},
      abstract     = {To investigate the predictive value of striatal dopamine
                      turnover in patients with de novo Parkinson's disease (PD)
                      for later occurrence of major non-motor health outcomes.This
                      retrospective, observer-blinded cohort study followed up 29
                      patients with de novo PD for a median of 10.7 years, who
                      completed 18Fluorodopa PET imaging to measure striatal
                      effective distribution volume ratio (EDVR, inverse of
                      dopamine turnover) prior to antiparkinsonian treatment.
                      Outcomes were assessed with a battery of non-motor,
                      health-related quality-of-life and non-motor fluctuation
                      (WOQ-19) measures and survival.During follow-up, $52\%$ of
                      patients developed wearing-off, $43\%$ neuropsychiatric
                      fluctuations, $35\%$ sensory fluctuations, $32\%$ dementia,
                      $46\%$ depression, $30\%$ psychosis, and PD-related
                      mortality was $26\%.$ Patients with wearing-off and
                      neuropsychiatric fluctuations showed significantly lower
                      baseline EDVR (higher dopamine turnover) in the putamen but
                      not in the caudate nucleus than those without these
                      fluctuations. Consistently, baseline EDVR in the putamen
                      predicted development of wearing-off and neuropsychiatric
                      fluctuations with a lower risk with higher EDVR (lower
                      dopamine turnover), whereas EDVR in caudate nucleus did not
                      correlate with these fluctuations. No relationships were
                      observed between baseline PET measures and the presence of
                      other major health outcomes including survival.Lower
                      putaminal dopamine turnover in de novo PD is associated with
                      reduced risk for later neuropsychiatric fluctuations
                      comprising a disease-intrinsic predisposing factor for their
                      development, similar as reported for levodopa-induced motor
                      complications. Striatal (putaminal/caudate) dopamine
                      turnover is not predictive for other long-term major health
                      outcomes. These results should be treated as hypothesis
                      generating and require confirmation.},
      keywords     = {Aged / Caudate Nucleus: diagnostic imaging / Caudate
                      Nucleus: metabolism / Dopamine: metabolism / Female /
                      Fluorodeoxyglucose F18 / Humans / Male / Neuropsychological
                      Tests / Parkinson Disease: diagnostic imaging / Parkinson
                      Disease: metabolism / Parkinson Disease: psychology /
                      Positron-Emission Tomography / Putamen: diagnostic imaging /
                      Putamen: metabolism / Quality of Life / Retrospective
                      Studies},
      cin          = {AG Teipel / AG Storch},
      ddc          = {610},
      cid          = {I:(DE-2719)1510100 / I:(DE-2719)5000014},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31381528},
      doi          = {10.3233/JPD-191672},
      url          = {https://pub.dzne.de/record/141513},
}