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@ARTICLE{Chen:141514,
      author       = {Chen, Xiaoli and Vieweg, Paula and Wolbers, Thomas},
      title        = {{C}omputing distance information from landmarks and
                      self-motion cues - {D}ifferential contributions of
                      anterior-lateral vs. posterior-medial entorhinal cortex in
                      humans.},
      journal      = {NeuroImage},
      volume       = {202},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {DZNE-2020-07838},
      pages        = {116074},
      year         = {2019},
      abstract     = {Landmarks and path integration cues are two important
                      sources of spatial information for navigation. For example,
                      both can be used to compute positional information, which,
                      in rodents, has been related to computations in the
                      entorhinal cortex. In humans, however, if and how the
                      entorhinal cortex supports landmark-based navigation and
                      path integration is poorly understood. To address this
                      important question, we developed a novel spatial navigation
                      task in which participants learned a target location and
                      judged relative positions of test locations in relation to
                      the target. Landmarks and path integration cues were
                      dissociated, and their reliability levels were manipulated.
                      Using fMRI adaptation, we investigated whether spatial
                      distances among the test locations were encoded in the BOLD
                      responses, separately for landmarks and self-motion cues.
                      The results showed that the anterior-lateral entorhinal
                      cortex adapted to the distance between successively visited
                      test locations when landmarks were used for localization,
                      meaning that its activation decreased as the distance
                      between the currently occupied location and the preceding
                      location decreased. In contrast, the posterior-medial
                      entorhinal cortex adapted to between-location distance when
                      path integration cues were used for localization. In
                      addition, along with the hippocampus and the precuneus, both
                      entorhinal subregions showed stronger activation in correct
                      trials than incorrect trials, regardless of cue type and
                      reliability level. Together, these findings suggest that
                      subdivisions of entorhinal cortex encode fine-grained
                      spatial information for different spatial cues, which
                      provides important insights into how the entorhinal cortex
                      supports different modes of spatial navigation.},
      keywords     = {Adult / Cues / Entorhinal Cortex: physiology / Female /
                      Humans / Magnetic Resonance Imaging / Male / Spatial
                      Navigation: physiology / Young Adult},
      cin          = {AG Wolbers},
      ddc          = {610},
      cid          = {I:(DE-2719)1310002},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31386919},
      doi          = {10.1016/j.neuroimage.2019.116074},
      url          = {https://pub.dzne.de/record/141514},
}