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@ARTICLE{Schweyer:141558,
      author       = {Schweyer, Kerstin and Rüschoff-Steiner, Corinna and
                      Arias-Carrión, Oscar and Oertel, Wolfgang H and Rösler,
                      Thomas W and Höglinger, Günter},
      title        = {{N}euronal precursor cells with dopaminergic commitment in
                      the rostral migratory stream of the mouse.},
      journal      = {Scientific reports},
      volume       = {9},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DZNE-2020-07882},
      pages        = {13359},
      year         = {2019},
      abstract     = {Neuroblasts born in the subventricular zone of adult
                      mammals migrate via the rostral migratory stream into the
                      granular cell layer or periglomerular layer of the olfactory
                      bulb to differentiate into interneurons. To analyze if new
                      neurons in the granular cell layer or periglomerular layer
                      have different origins, we inserted a physical barrier into
                      the rostral migratory stream, depleted cell proliferation
                      with cytarabine infusions, labeled newborn cells with
                      bromodeoxyuridine, and sacrificed mice after short-term (0,
                      2, or 14 days) or long-term (55 or 105 days) intervals.
                      After short-term survival, the subventricular zone and
                      rostral migratory stream rapidly repopulated with
                      bromodeoxyuridine+ cells after cytarabine-induced depletion.
                      Nestin, glial fibrillary acidic protein and the PAX6 were
                      expressed in bromodeoxyuridine+ cells within the rostral
                      migratory stream downstream of the physical barrier. After
                      long-term survival after physical barrier implantation,
                      bromodeoxyuridine+ neurons were significantly reduced in the
                      granular cell layer, but bromodeoxyuridine+ and dopaminergic
                      neurons in the periglomerular layer remained unaffected by
                      the physical barrier. Thus, newborn neurons for the granular
                      cell layer are mainly recruited from neural stem cells
                      located in the subventricular zone, but new neurons for the
                      periglomerular layer with dopaminergic predisposition can
                      rise as well from neuronal stem or precursor cells in the
                      rostral migratory stream.},
      keywords     = {Animals / Bromodeoxyuridine: metabolism / Cell
                      Differentiation: physiology / Cell Movement: physiology /
                      Cell Proliferation: physiology / Dopamine: metabolism /
                      Dopaminergic Neurons: metabolism / Interneurons: metabolism
                      / Lateral Ventricles: metabolism / Male / Mice / Mice,
                      Inbred C57BL / Neural Stem Cells: metabolism / Neural Stem
                      Cells: physiology / Olfactory Bulb: metabolism},
      cin          = {AG Höglinger 1},
      ddc          = {600},
      cid          = {I:(DE-2719)1110002},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31527656},
      pmc          = {pmc:PMC6746949},
      doi          = {10.1038/s41598-019-49920-5},
      url          = {https://pub.dzne.de/record/141558},
}