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000141584 0247_ $$2doi$$a10.1016/j.parkreldis.2019.09.032
000141584 0247_ $$2pmid$$apmid:31621617
000141584 0247_ $$2ISSN$$a1353-8020
000141584 0247_ $$2ISSN$$a1873-5126
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000141584 037__ $$aDZNE-2020-07908
000141584 041__ $$aEnglish
000141584 082__ $$a610
000141584 1001_ $$0P:(DE-HGF)0$$aAlonso-Canovas, Araceli$$b0$$eCorresponding author
000141584 245__ $$aTranscranial sonography in atypical parkinsonism: How reliable is it in real clinical practice? A multicentre comprehensive study.
000141584 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2019
000141584 264_1 $$2Crossref$$3print$$bElsevier BV$$c2019-11-01
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000141584 520__ $$aSubstantia nigra hyperechogenicity (SN+) in transcranial sonography (TCS) is frequent in Parkinson's disease (PD), while lenticular nucleus hyperechogenicity (LN+) and 3rd ventricle enlargement (3V+) are typical of Atypical Parkinsonisms (AP). However, there are no studies assessing the diagnostic yield of all TCS biomarkers in the three AP (progressive supranuclear palsy, PSP, multiple system atrophy, MSA, corticobasal degeneration, CBD). Previous references lack homogeneous criteria and data are incomprehensive.Analysis of TCS performed in routine clinical practice in AP and PD patients from two tertiary hospitals. Expert recommendations were strictly followed. Previous literature was critically analysed.155 AP (98 PSP, 40 MSA, 14 CBD), 254 PD, 145 control subjects were included. We confirmed good sensitivity for SN+ in PD (80%), but specificity was lower than reported (61%). LN+ and 3V + had moderate sensitivity for AP and PSP diagnosis respectively (65%, 63%), but specificity was higher than reported (87%, 91%). We confirmed high specificity and positive predictive value of the combination SN/LN (98%, 93% AP; 83%, 86% PD). The combinations of two or three echofeatures, previously unreported, showed high specificity but lower sensitivity (SN/3V: 75% sensitivity, 87% specificity PD; 42% sensitivity, 98% specificity PSP) (SN + LN+: 79% sensitivity, 86% specificity CBD) (SN/3V/LN: 67% sensitivity, 89% specificity PD; 29% sensitivity, 99% specificity PSP; 41% sensitivity, 95% specificity MSA; 57% sensitivity 91% specificity CBD).We present a large comprehensive study of TCS, confirming its usefulness and certain limitations in AP diagnosis. Adherence to consensus criteria is critical to implement TCS for clinical and research purposes.
000141584 536__ $$0G:(DE-HGF)POF3-344$$a344 - Clinical and Health Care Research (POF3-344)$$cPOF3-344$$fPOF III$$x0
000141584 542__ $$2Crossref$$i2019-11-01$$uhttps://www.elsevier.com/tdm/userlicense/1.0/
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000141584 650_2 $$2MeSH$$aAged
000141584 650_2 $$2MeSH$$aAged, 80 and over
000141584 650_2 $$2MeSH$$aCorpus Striatum: diagnostic imaging
000141584 650_2 $$2MeSH$$aFemale
000141584 650_2 $$2MeSH$$aHumans
000141584 650_2 $$2MeSH$$aMale
000141584 650_2 $$2MeSH$$aMiddle Aged
000141584 650_2 $$2MeSH$$aParkinsonian Disorders: diagnostic imaging
000141584 650_2 $$2MeSH$$aReproducibility of Results
000141584 650_2 $$2MeSH$$aSensitivity and Specificity
000141584 650_2 $$2MeSH$$aSubstantia Nigra: diagnostic imaging
000141584 650_2 $$2MeSH$$aThird Ventricle: diagnostic imaging
000141584 650_2 $$2MeSH$$aUltrasonography, Doppler, Transcranial: standards
000141584 7001_ $$0P:(DE-HGF)0$$aTembl Ferrairó, José Ignacio$$b1
000141584 7001_ $$0P:(DE-HGF)0$$aMartínez-Torres, Irene$$b2
000141584 7001_ $$0P:(DE-HGF)0$$aLopez-Sendon Moreno, Jose Luis$$b3
000141584 7001_ $$0P:(DE-HGF)0$$aParees-Moreno, Isabel$$b4
000141584 7001_ $$0P:(DE-HGF)0$$aMonreal-Laguillo, Enric$$b5
000141584 7001_ $$0P:(DE-HGF)0$$aPérez-Torre, Paula$$b6
000141584 7001_ $$0P:(DE-HGF)0$$aToledano Delgado, Rafael$$b7
000141584 7001_ $$0P:(DE-HGF)0$$aGarcía Ribas, Guillermo$$b8
000141584 7001_ $$0P:(DE-HGF)0$$aSastre Bataller, Isabel$$b9
000141584 7001_ $$0P:(DE-HGF)0$$aMasjuan, Jaime$$b10
000141584 7001_ $$0P:(DE-HGF)0$$aMartinez-Castrillo, Juan Carlos$$b11
000141584 7001_ $$0P:(DE-2719)9000336$$aWalter, Uwe$$b12$$eLast author$$udzne
000141584 77318 $$2Crossref$$3journal-article$$a10.1016/j.parkreldis.2019.09.032$$b : Elsevier BV, 2019-11-01$$p40-45$$tParkinsonism & Related Disorders$$v68$$x1353-8020$$y2019
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