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| 001 | 141593 | ||
| 005 | 20250415111424.0 | ||
| 024 | 7 | _ | |a pmc:PMC7055269 |2 pmc |
| 024 | 7 | _ | |a 10.1038/s41588-019-0511-y |2 doi |
| 024 | 7 | _ | |a pmid:31636452 |2 pmid |
| 024 | 7 | _ | |a 1061-4036 |2 ISSN |
| 024 | 7 | _ | |a 1546-1718 |2 ISSN |
| 024 | 7 | _ | |a altmetric:69055564 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-07917 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Satizabal, Claudia L |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Genetic architecture of subcortical brain structures in 38,851 individuals. |
| 260 | _ | _ | |a London |c 2019 |b Macmillan Publishers Limited, part of Springer Nature |
| 264 | _ | 1 | |3 online |2 Crossref |b Springer Science and Business Media LLC |c 2019-10-21 |
| 264 | _ | 1 | |3 print |2 Crossref |b Springer Science and Business Media LLC |c 2019-11-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1744708416_28682 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease. |
| 536 | _ | _ | |a 344 - Clinical and Health Care Research (POF3-344) |0 G:(DE-HGF)POF3-344 |c POF3-344 |f POF III |x 0 |
| 542 | _ | _ | |i 2019-10-21 |2 Crossref |u http://www.springer.com/tdm |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 2 | |a Adult |2 MeSH |
| 650 | _ | 2 | |a Aged |2 MeSH |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Brain: anatomy & histology |2 MeSH |
| 650 | _ | 2 | |a Brain: metabolism |2 MeSH |
| 650 | _ | 2 | |a Cohort Studies |2 MeSH |
| 650 | _ | 2 | |a Drosophila melanogaster: genetics |2 MeSH |
| 650 | _ | 2 | |a Drosophila melanogaster: growth & development |2 MeSH |
| 650 | _ | 2 | |a Drosophila melanogaster: metabolism |2 MeSH |
| 650 | _ | 2 | |a Genetic Variation |2 MeSH |
| 650 | _ | 2 | |a Genome-Wide Association Study |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Magnetic Resonance Imaging |2 MeSH |
| 650 | _ | 2 | |a Middle Aged |2 MeSH |
| 650 | _ | 2 | |a Neurodevelopmental Disorders: genetics |2 MeSH |
| 650 | _ | 2 | |a Neurodevelopmental Disorders: pathology |2 MeSH |
| 650 | _ | 2 | |a Organ Size |2 MeSH |
| 700 | 1 | _ | |a Adams, Hieab H H |b 1 |
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| 700 | 1 | _ | |a White, Charles C |b 3 |
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| 700 | 1 | _ | |a Scholz, Markus |b 6 |
| 700 | 1 | _ | |a Sargurupremraj, Muralidharan |b 7 |
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| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1212/WNL.32.5.514 |2 Crossref |o 10.1212/WNL.32.5.514 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nrn1919 |2 Crossref |o 10.1038/nrn1919 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/jnr.23709 |2 Crossref |o 10.1002/jnr.23709 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1146/annurev-neuro-071013-013924 |2 Crossref |o 10.1146/annurev-neuro-071013-013924 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1146/annurev.neuro.051508.135256 |2 Crossref |o 10.1146/annurev.neuro.051508.135256 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1146/annurev-psych-010213-115159 |2 Crossref |o 10.1146/annurev-psych-010213-115159 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.3389/fnhum.2015.00157 |2 Crossref |o 10.3389/fnhum.2015.00157 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1146/annurev.ne.09.030186.002041 |2 Crossref |o 10.1146/annurev.ne.09.030186.002041 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nrn4038 |2 Crossref |o 10.1038/nrn4038 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nrn3469 |2 Crossref |o 10.1038/nrn3469 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1111/bpa.12289 |2 Crossref |o 10.1111/bpa.12289 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/jnen/61.5.413 |2 Crossref |o 10.1093/jnen/61.5.413 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nature14101 |2 Crossref |o 10.1038/nature14101 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/s41586-018-0571-7 |2 Crossref |o 10.1038/s41586-018-0571-7 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1111/gbb.12177 |2 Crossref |o 10.1111/gbb.12177 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nmeth.1974 |2 Crossref |o 10.1038/nmeth.1974 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ng.3643 |2 Crossref |o 10.1038/ng.3643 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/bioinformatics/btq340 |2 Crossref |o 10.1093/bioinformatics/btq340 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/bioinformatics/btq419 |2 Crossref |o 10.1093/bioinformatics/btq419 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ncomms13624 |2 Crossref |o 10.1038/ncomms13624 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nn.4398 |2 Crossref |o 10.1038/nn.4398 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1161/CIRCGENETICS.114.000858 |2 Crossref |o 10.1161/CIRCGENETICS.114.000858 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/s41588-018-0058-3 |2 Crossref |o 10.1038/s41588-018-0058-3 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/hmg/ddy271 |2 Crossref |o 10.1093/hmg/ddy271 |
| 999 | C | 5 | |y 2018 |2 Crossref |o G Davies 2018 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/s41588-019-0358-2 |2 Crossref |o 10.1038/s41588-019-0358-2 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ng.487 |2 Crossref |o 10.1038/ng.487 |
| 999 | C | 5 | |2 Crossref |o |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/s41588-018-0269-7 |2 Crossref |o 10.1038/s41588-018-0269-7 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ng.3404 |2 Crossref |o 10.1038/ng.3404 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.cell.2013.09.053 |2 Crossref |o 10.1016/j.cell.2013.09.053 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/nar/gku1003 |2 Crossref |o 10.1093/nar/gku1003 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neuron.2011.06.026 |2 Crossref |o 10.1016/j.neuron.2011.06.026 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/cne.21740 |2 Crossref |o 10.1002/cne.21740 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.M112.426304 |2 Crossref |o 10.1074/jbc.M112.426304 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1056/NEJMoa003147 |2 Crossref |o 10.1056/NEJMoa003147 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.cardfail.2011.05.011 |2 Crossref |o 10.1016/j.cardfail.2011.05.011 |
| 999 | C | 5 | |y 2013 |2 Crossref |o B Desbuquois 2013 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1111/cei.13080 |2 Crossref |o 10.1111/cei.13080 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.stem.2013.09.016 |2 Crossref |o 10.1016/j.stem.2013.09.016 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1172/JCI80323 |2 Crossref |o 10.1172/JCI80323 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.csbj.2014.12.004 |2 Crossref |o 10.1016/j.csbj.2014.12.004 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.M110.145003 |2 Crossref |o 10.1074/jbc.M110.145003 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1159/000329722 |2 Crossref |o 10.1159/000329722 |
| 999 | C | 5 | |y 2011 |2 Crossref |o KA Kellett 2011 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/tp.2015.192 |2 Crossref |o 10.1038/tp.2015.192 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/s10048-012-0349-2 |2 Crossref |o 10.1007/s10048-012-0349-2 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/s10072-015-2110-8 |2 Crossref |o 10.1007/s10072-015-2110-8 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.2548-14.2015 |2 Crossref |o 10.1523/JNEUROSCI.2548-14.2015 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.0575-06.2006 |2 Crossref |o 10.1523/JNEUROSCI.0575-06.2006 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.M301558200 |2 Crossref |o 10.1074/jbc.M301558200 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.152313999 |2 Crossref |o 10.1073/pnas.152313999 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1242/dev.097774 |2 Crossref |o 10.1242/dev.097774 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1091/mbc.e07-09-0878 |2 Crossref |o 10.1091/mbc.e07-09-0878 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nrn.2016.18 |2 Crossref |o 10.1038/nrn.2016.18 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/tp.2015.151 |2 Crossref |o 10.1038/tp.2015.151 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nn.3276 |2 Crossref |o 10.1038/nn.3276 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ng.3043 |2 Crossref |o 10.1038/ng.3043 |
| 999 | C | 5 | |y 2015 |2 Crossref |o JJ Guan 2015 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.3390/ijms151019253 |2 Crossref |o 10.3390/ijms151019253 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1371/journal.pgen.1006137 |2 Crossref |o 10.1371/journal.pgen.1006137 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1111/acel.12625 |2 Crossref |o 10.1111/acel.12625 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.ydbio.2016.08.018 |2 Crossref |o 10.1016/j.ydbio.2016.08.018 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neulet.2010.07.068 |2 Crossref |o 10.1016/j.neulet.2010.07.068 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1242/jcs.01326 |2 Crossref |o 10.1242/jcs.01326 |
| 999 | C | 5 | |y 2012 |2 Crossref |o XA Liu 2012 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/hmg/dds373 |2 Crossref |o 10.1093/hmg/dds373 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1021/pr2012279 |2 Crossref |o 10.1021/pr2012279 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/hmg/ddt478 |2 Crossref |o 10.1093/hmg/ddt478 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/ar.1091670402 |2 Crossref |o 10.1002/ar.1091670402 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1101/cshperspect.a018309 |2 Crossref |o 10.1101/cshperspect.a018309 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/s41380-018-0112-7 |2 Crossref |o 10.1038/s41380-018-0112-7 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/s41398-018-0150-6 |2 Crossref |o 10.1038/s41398-018-0150-6 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1161/CIRCGENETICS.108.829747 |2 Crossref |o 10.1161/CIRCGENETICS.108.829747 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/s11682-013-9269-5 |2 Crossref |o 10.1007/s11682-013-9269-5 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1371/journal.pmed.1001779 |2 Crossref |o 10.1371/journal.pmed.1001779 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/ije/dyv337 |2 Crossref |o 10.1093/ije/dyv337 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1159/000110396 |2 Crossref |o 10.1159/000110396 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1086/301844 |2 Crossref |o 10.1086/301844 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.ajhg.2010.11.011 |2 Crossref |o 10.1016/j.ajhg.2010.11.011 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ng.3211 |2 Crossref |o 10.1038/ng.3211 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nprot.2014.071 |2 Crossref |o 10.1038/nprot.2014.071 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.bcp.2014.01.037 |2 Crossref |o 10.1016/j.bcp.2014.01.037 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nn.4126 |2 Crossref |o 10.1038/nn.4126 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/biostatistics/kxj037 |2 Crossref |o 10.1093/biostatistics/kxj037 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nature14248 |2 Crossref |o 10.1038/nature14248 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/nar/gku1202 |2 Crossref |o 10.1093/nar/gku1202 |
| 999 | C | 5 | |y 2014 |2 Crossref |o X Zhang 2014 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/database/bav025 |2 Crossref |o 10.1093/database/bav025 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ng.2653 |2 Crossref |o 10.1038/ng.2653 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1371/journal.pgen.1000214 |2 Crossref |o 10.1371/journal.pgen.1000214 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.2174/156720512801322663 |2 Crossref |o 10.2174/156720512801322663 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.2174/156720512801322573 |2 Crossref |o 10.2174/156720512801322573 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/ana.24337 |2 Crossref |o 10.1002/ana.24337 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1212/01.wnl.0000242734.16663.09 |2 Crossref |o 10.1212/01.wnl.0000242734.16663.09 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1212/WNL.47.5.1113 |2 Crossref |o 10.1212/WNL.47.5.1113 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/ana.20723 |2 Crossref |o 10.1002/ana.20723 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/bioinformatics/btw613 |2 Crossref |o 10.1093/bioinformatics/btw613 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1242/dmm.027680 |2 Crossref |o 10.1242/dmm.027680 |
| 999 | C | 5 | |y 2011 |2 Crossref |o Y Hu 2011 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/978-1-4939-6371-3_1 |2 Crossref |o 10.1007/978-1-4939-6371-3_1 |
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