%0 Journal Article
%A Priglinger, Claudia
%A Klopstock, Thomas
%A Rudolph, Günter
%A Priglinger, Siegfried Georg
%T [Leber's Hereditary Optic Neuropathy].
%J Klinische Monatsblätter für Augenheilkunde
%V 236
%N 11
%@ 0023-2165
%C Stuttgart
%I Thieme78968
%M DZNE-2020-07919
%P 1271-1282
%D 2019
%X Leber's hereditary optic neuropathy (LHON) typically affects young adults with a higher prevalence in men, but can ultimately occur at any age and also in women. LHON is caused by point mutations in the mitochondrial DNA, which lead to a defect in complex I of the mitochondrial respiratory chain. This in turn causes dysfunction and later degeneration of retinal ganglion cells, followed by ascending optic atrophy. Classically, LHON presents as a subacute unilateral loss of visual acuity, dyschromatopsia in the red-green axis and a central or centrocecal scotoma. The partner eye usually develops similar symptoms within 3 - 6 months of onset of the disease. In 25
%K DNA, Mitochondrial
%K Female
%K Genetic Therapy
%K Humans
%K Male
%K Optic Atrophy, Hereditary, Leber: genetics
%K Optic Atrophy, Hereditary, Leber: therapy
%K Retinal Ganglion Cells
%K Visual Acuity
%K Young Adult
%K DNA, Mitochondrial (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31639883
%R 10.1055/a-0972-1552
%U https://pub.dzne.de/record/141595