TY  - JOUR
AU  - Priglinger, Claudia
AU  - Klopstock, Thomas
AU  - Rudolph, Günter
AU  - Priglinger, Siegfried Georg
TI  - [Leber's Hereditary Optic Neuropathy].
JO  - Klinische Monatsblätter für Augenheilkunde
VL  - 236
IS  - 11
SN  - 0023-2165
CY  - Stuttgart
PB  - Thieme78968
M1  - DZNE-2020-07919
SP  - 1271-1282
PY  - 2019
AB  - Leber's hereditary optic neuropathy (LHON) typically affects young adults with a higher prevalence in men, but can ultimately occur at any age and also in women. LHON is caused by point mutations in the mitochondrial DNA, which lead to a defect in complex I of the mitochondrial respiratory chain. This in turn causes dysfunction and later degeneration of retinal ganglion cells, followed by ascending optic atrophy. Classically, LHON presents as a subacute unilateral loss of visual acuity, dyschromatopsia in the red-green axis and a central or centrocecal scotoma. The partner eye usually develops similar symptoms within 3 - 6 months of onset of the disease. In 25
KW  - DNA, Mitochondrial
KW  - Female
KW  - Genetic Therapy
KW  - Humans
KW  - Male
KW  - Optic Atrophy, Hereditary, Leber: genetics
KW  - Optic Atrophy, Hereditary, Leber: therapy
KW  - Retinal Ganglion Cells
KW  - Visual Acuity
KW  - Young Adult
KW  - DNA, Mitochondrial (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:31639883
DO  - DOI:10.1055/a-0972-1552
UR  - https://pub.dzne.de/record/141595
ER  -