%0 Journal Article
%A Nalls, Mike A
%A Blauwendraat, Cornelis
%A Vallerga, Costanza L
%A Heilbron, Karl
%A Bandres-Ciga, Sara
%A Chang, Diana
%A Tan, Manuela
%A Kia, Demis A
%A Noyce, Alastair J
%A Xue, Angli
%A Bras, Jose
%A Young, Emily
%A von Coelln, Rainer
%A Simon Sanchez, Javier
%A Schulte, Claudia
%A Sharma, Manu
%A Krohn, Lynne
%A Pihlstrøm, Lasse
%A Siitonen, Ari
%A Iwaki, Hirotaka
%A Leonard, Hampton
%A Faghri, Faraz
%A Gibbs, J Raphael
%A Hernandez, Dena G
%A Scholz, Sonja W
%A Botia, Juan A
%A Martinez, Maria
%A Corvol, Jean-Christophe
%A Lesage, Suzanne
%A Jankovic, Joseph
%A Shulman, Lisa M
%A Sutherland, Margaret
%A Tienari, Pentti
%A Majamaa, Kari
%A Toft, Mathias
%A Andreassen, Ole A
%A Bangale, Tushar
%A Brice, Alexis
%A Yang, Jian
%A Gan-Or, Ziv
%A Gasser, Thomas
%A Heutink, Peter
%A Shulman, Joshua M
%A Wood, Nicholas W
%A Hinds, David A
%A Hardy, John A
%A Morris, Huw R
%A Gratten, Jacob
%A Visscher, Peter M
%A Graham, Robert R
%A Singleton, Andrew B
%A Team, 23andMe Research
%A Consortium, System Genomics of Parkinson's Disease
%A Consortium, International Parkinson's Disease Genomics
%A Adarmes-Gómez, Astrid D
%A Aguilar, Miquel
%A Aitkulova, Akbota
%A Akhmetzhanov, Vadim
%A Alcalay, Roy N
%A Alvarez, Ignacio
%A Alvarez, Victoria
%A Bandres-Ciga, Sara
%A Barrero, Francisco Javier
%A Bergareche Yarza, Jesús Alberto
%A Bernal-Bernal, Inmaculada
%A Billingsley, Kimberley
%A Blauwendraat, Cornelis
%A Blazquez, Marta
%A Bonilla-Toribio, Marta
%A Botía, Juan A
%A Boungiorno, María Teresa
%A Bras, Jose
%A Brice, Alexis
%A Brockmann, Kathrin
%A Bubb, Vivien
%A Buiza-Rueda, Dolores
%A Cámara, Ana
%A Carrillo, Fátima
%A Carrión-Claro, Mario
%A Cerdan, Debora
%A Chelban, Viorica
%A Clarimón, Jordi
%A Clarke, Carl
%A Compta, Yaroslau
%A Cookson, Mark R
%A Corvol, Jean-Christophe
%A Craig, David W
%A Danjou, Fabrice
%A Diez-Fairen, Monica
%A Dols-Icardo, Oriol
%A Duarte, Jacinto
%A Duran, Raquel
%A Escamilla-Sevilla, Francisco
%A Escott-Price, Valentina
%A Ezquerra, Mario
%A Faghri, Faraz
%A Feliz, Cici
%A Fernández, Manel
%A Fernández-Santiago, Rubén
%A Finkbeiner, Steven
%A Foltynie, Thomas
%A Gan-Or, Ziv
%A Garcia, Ciara
%A García-Ruiz, Pedro
%A Gibbs, J Raphael
%A Gomez Heredia, Maria Jose
%A Gómez-Garre, Pilar
%A González, Manuel Menéndez
%A Gonzalez-Aramburu, Isabel
%A Guelfi, Sebastian
%A Guerreiro, Rita
%A Hardy, John
%A Hassin-Baer, Sharon
%A Hernandez, Dena G
%A Hoenicka, Janet
%A Holmans, Peter
%A Houlden, Henry
%A Infante, Jon
%A Iwaki, Hirotaka
%A Jesús, Silvia
%A Jimenez-Escrig, Adriano
%A Kaishybayeva, Gulnaz
%A Kaiyrzhanov, Rauan
%A Karimova, Altynay
%A Kia, Demis A
%A Kinghorn, Kerri J
%A Koks, Sulev
%A Krohn, Lynne
%A Kulisevsky, Jaime
%A Labrador-Espinosa, Miguel A
%A Leonard, Hampton L
%A Lesage, Suzanne
%A Lewis, Patrick
%A Lopez-Sendon, Jose Luis
%A Lovering, Ruth
%A Lubbe, Steven
%A Lungu, Codrin
%A Macias, Daniel
%A Majamaa, Kari
%A Manzoni, Claudia
%A Marín, Juan
%A Marinus, Johan
%A Marti, Maria Jose
%A Martinez, Maria
%A Martínez Torres, Irene
%A Martínez-Castrillo, Juan Carlos
%A Mata, Marina
%A Mencacci, Niccolo E
%A Méndez-Del-Barrio, Carlota
%A Middlehurst, Ben
%A Mínguez, Adolfo
%A Mir, Pablo
%A Mok, Kin Y
%A Morris, Huw R
%A Muñoz, Esteban
%A Nalls, Mike A
%A Narendra, Derek
%A Noyce, Alastair J
%A Ojo, Oluwadamilola O
%A Okubadejo, Njideka U
%A Pagola, Ana Gorostidi
%A Pastor, Pau
%A Perez Errazquin, Francisco
%A Periñán-Tocino, Teresa
%A Pihlstrom, Lasse
%A Plun-Favreau, Helene
%A Quinn, John
%A R'Bibo, Lea
%A Reed, Xylena
%A Rezola, Elisabet Mondragon
%A Rizig, Mie
%A Rizzu, Patrizia
%A Robak, Laurie
%A Rodriguez, Antonio Sanchez
%A Rouleau, Guy A
%A Ruiz-Martínez, Javier
%A Ruz, Clara
%A Ryten, Mina
%A Sadykova, Dinara
%A Scholz, Sonja W
%A Schreglmann, Sebastian
%A Schulte, Claudia
%A Sharma, Manu
%A Shashkin, Chingiz
%A Shulman, Joshua M
%A Sierra, María
%A Siitonen, Ari
%A Singleton, Andrew B
%A Suarez-Sanmartin, Esther
%A Taba, Pille
%A Tabernero, Cesar
%A Tan, Manuela X
%A Tartari, Juan Pablo
%A Tejera-Parrado, Cristina
%A Toft, Mathias
%A Tolosa, Eduard
%A Trabzuni, Daniah
%A Valldeoriola, Francesc
%A van Hilten, Jacobus J
%A Van Keuren-Jensen, Kendall
%A Vargas-González, Laura
%A Vela, Lydia
%A Vives, Francisco
%A Williams, Nigel
%A Wood, Nicholas W
%A Zharkinbekova, Nazira
%A Zharmukhanov, Zharkyn
%A Zholdybayeva, Elena
%A Zimprich, Alexander
%A Ylikotila, Pauli
%A Shulman, Lisa M
%A von Coelln, Rainer
%A Reich, Stephen
%A Savitt, Joseph
%A Agee, Michelle
%A Alipanahi, Babak
%A Auton, Adam
%A Bell, Robert K
%A Bryc, Katarzyna
%A Elson, Sarah L
%A Fontanillas, Pierre
%A Furlotte, Nicholas A
%A Huber, Karen E
%A Hicks, Barry
%A Jewett, Ethan M
%A Jiang, Yunxuan
%A Kleinman, Aaron
%A Lin, Keng-Han
%A Litterman, Nadia K
%A McCreight, Jennifer C
%A McIntyre, Matthew H
%A McManus, Kimberly F
%A Mountain, Joanna L
%A Noblin, Elizabeth S
%A Northover, Carrie A M
%A Pitts, Steven J
%A Poznik, G David
%A Sathirapongsasuti, J Fah
%A Shelton, Janie F
%A Shringarpure, Suyash
%A Tian, Chao
%A Tung, Joyce
%A Vacic, Vladimir
%A Wang, Xin
%A Wilson, Catherine H
%A Anderson, Tim
%A Bentley, Steven
%A Dalrymple-Alford, John
%A Fowdar, Javed
%A Gratten, Jacob
%A Halliday, Glenda
%A Henders, Anjali K
%A Hickie, Ian
%A Kassam, Irfahan
%A Kennedy, Martin
%A Kwok, John
%A Lewis, Simon
%A Mellick, George
%A Montgomery, Grant
%A Pearson, John
%A Pitcher, Toni
%A Sidorenko, Julia
%A Silburn, Peter A
%A Vallerga, Costanza L
%A Visscher, Peter M
%A Wallace, Leanne
%A Wray, Naomi R
%A Xue, Angli
%A Yang, Jian
%A Zhang, Futao
%T Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies.
%J The lancet  / Neurology
%V 18
%N 12
%@ 1474-4422
%C London
%I Lancet Publ. Group
%M DZNE-2020-07948
%P 1091-1102
%D 2019
%X Genome-wide association studies (GWAS) in Parkinson's disease have increased the scope of biological knowledge about the disease over the past decade. We aimed to use the largest aggregate of GWAS data to identify novel risk loci and gain further insight into the causes of Parkinson's disease.We did a meta-analysis of 17 datasets from Parkinson's disease GWAS available from European ancestry samples to nominate novel loci for disease risk. These datasets incorporated all available data. We then used these data to estimate heritable risk and develop predictive models of this heritability. We also used large gene expression and methylation resources to examine possible functional consequences as well as tissue, cell type, and biological pathway enrichments for the identified risk factors. Additionally, we examined shared genetic risk between Parkinson's disease and other phenotypes of interest via genetic correlations followed by Mendelian randomisation.Between Oct 1, 2017, and Aug 9, 2018, we analysed 7·8 million single nucleotide polymorphisms in 37 688 cases, 18 618 UK Biobank proxy-cases (ie, individuals who do not have Parkinson's disease but have a first degree relative that does), and 1·4 million controls. We identified 90 independent genome-wide significant risk signals across 78 genomic regions, including 38 novel independent risk signals in 37 loci. These 90 variants explained 16-36
%K Databases, Genetic
%K Genetic Loci: genetics
%K Genetic Predisposition to Disease: epidemiology
%K Genetic Predisposition to Disease: genetics
%K Genome-Wide Association Study: methods
%K Humans
%K Parkinson Disease: diagnosis
%K Parkinson Disease: epidemiology
%K Parkinson Disease: genetics
%K Risk Factors
%F PUB:(DE-HGF)16
%9 Journal Article
%2 pmc:PMC8422160
%$ pmid:31701892
%R 10.1016/S1474-4422(19)30320-5
%U https://pub.dzne.de/record/141624