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@ARTICLE{Timus:141658,
      author       = {Timäus, Charles and Meiser, Miriam and Bandelow, Borwin
                      and Engel, Kirsten R and Paschke, Anne M and Wiltfang, Jens
                      and Wedekind, Dirk},
      title        = {{P}harmacotherapy of borderline personality disorder: what
                      has changed over two decades? {A} retrospective evaluation
                      of clinical practice.},
      journal      = {BMC psychiatry},
      volume       = {19},
      number       = {1},
      issn         = {1471-244X},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DZNE-2020-07982},
      pages        = {393},
      year         = {2019},
      abstract     = {The purpose of this study was to assess the pharmacological
                      treatment strategies of inpatients with borderline
                      personality disorder between 2008 and 2012. Additionally, we
                      compared pharmacotherapy during this period to a previous
                      one (1996 to 2004).Charts of 87 patients with the main
                      diagnosis of borderline personality disorder receiving
                      inpatient treatment in the University Medical Center of
                      Goettingen, Germany, between 2008 and 2012 were evaluated
                      retrospectively. For each inpatient treatment, psychotropic
                      drug therapy including admission and discharge medication
                      was documented. We compared the prescription rates of the
                      interval 2008-2012 with the interval $1996-2004.94\%$ of all
                      inpatients of the interval 2008-2012 were treated with at
                      least one psychotropic drug at time of discharge. All
                      classes of psychotropic drugs were applied. We found high
                      prescription rates of naltrexone $(35.6\%),$ quetiapine
                      $(19.5\%),$ mirtazapine $(18.4\%),$ sertraline $(12.6\%),$
                      and escitalopram $(11.5\%).$ Compared to 1996-2004, rates of
                      low-potency antipsychotics, tri-/tetracyclic antidepressants
                      and mood stabilizers significantly decreased while usage of
                      naltrexone significantly increased.In inpatient settings,
                      pharmacotherapy is still highly prevalent in the management
                      of BPD. Prescription strategies changed between 1996 and
                      2012. Quetiapine was preferred, older antidepressants and
                      low-potency antipsychotics were avoided. Opioid antagonists
                      are increasingly used and should be considered for further
                      investigation.},
      keywords     = {Adult / Anticonvulsants: therapeutic use / Antidepressive
                      Agents: therapeutic use / Antimanic Agents: therapeutic use
                      / Antipsychotic Agents: therapeutic use / Borderline
                      Personality Disorder: drug therapy / Borderline Personality
                      Disorder: epidemiology / Borderline Personality Disorder:
                      psychology / Female / Germany: epidemiology /
                      Hospitalization: trends / Humans / Male / Middle Aged /
                      Narcotic Antagonists: therapeutic use / Prevalence /
                      Psychotropic Drugs: therapeutic use / Retrospective Studies
                      / Time Factors / Young Adult},
      cin          = {AG Wiltfang},
      ddc          = {610},
      cid          = {I:(DE-2719)1410006},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31830934},
      pmc          = {pmc:PMC6909459},
      doi          = {10.1186/s12888-019-2377-z},
      url          = {https://pub.dzne.de/record/141658},
}