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000141697 1001_ $$aBreithausen, Björn$$b0
000141697 245__ $$aLimited contribution of astroglial gap junction coupling to buffering of extracellular K+ in CA1 stratum radiatum.
000141697 260__ $$aBognor Regis [u.a.]$$bWiley-Liss$$c2019
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000141697 520__ $$aAstrocytes form large networks, in which individual cells are connected via gap junctions. It is thought that this astroglial gap junction coupling contributes to the buffering of extracellular K+ increases. However, it is largely unknown how the control of extracellular K+ by astroglial gap junction coupling depends on the underlying activity patterns and on the magnitude of extracellular K+ increases. We explored this dependency in acute hippocampal slices (CA1, stratum radiatum) by direct K+ -sensitive microelectrode recordings and acute pharmacological inhibition of gap junctions. K+ transients evoked by synaptic and axonal activity were largely unaffected by acute astroglial uncoupling in slices obtained from young and adult rats. Iontophoretic K+ -application enabled us to generate K+ gradients with defined spatial properties and magnitude. By varying the K+ -iontophoresis position and protocol, we found that acute pharmacological uncoupling increases the amplitude of K+ transients once their initial amplitude exceeded ~10 mM. Our experiments demonstrate that the contribution of gap junction coupling to buffering of extracellular K+ gradients is limited to large and localized K+ increases.
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000141697 650_2 $$2MeSH$$aAnimals
000141697 650_2 $$2MeSH$$aAstrocytes: metabolism
000141697 650_2 $$2MeSH$$aCA1 Region, Hippocampal: metabolism
000141697 650_2 $$2MeSH$$aGap Junctions: metabolism
000141697 650_2 $$2MeSH$$aMembrane Potentials: physiology
000141697 650_2 $$2MeSH$$aNeurons: metabolism
000141697 650_2 $$2MeSH$$aPotassium: metabolism
000141697 650_2 $$2MeSH$$aRats
000141697 650_2 $$2MeSH$$aRats, Wistar
000141697 650_2 $$2MeSH$$aSynapses: metabolism
000141697 7001_ $$aKautzmann, Steffen$$b1
000141697 7001_ $$aBoehlen, Anne$$b2
000141697 7001_ $$0P:(DE-HGF)0$$aSteinhäuser, Christian$$b3
000141697 7001_ $$0P:(DE-2719)2811625$$aHenneberger, Christian$$b4$$eLast author$$udzne
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