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| 001 | 141697 | ||
| 005 | 20240321221012.0 | ||
| 024 | 7 | _ | |a 10.1002/glia.23751 |2 doi |
| 024 | 7 | _ | |a pmid:31743499 |2 pmid |
| 024 | 7 | _ | |a 0894-1491 |2 ISSN |
| 024 | 7 | _ | |a 1098-1136 |2 ISSN |
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| 037 | _ | _ | |a DZNE-2020-00028 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Breithausen, Björn |b 0 |
| 245 | _ | _ | |a Limited contribution of astroglial gap junction coupling to buffering of extracellular K+ in CA1 stratum radiatum. |
| 260 | _ | _ | |a Bognor Regis [u.a.] |c 2019 |b Wiley-Liss |
| 264 | _ | 1 | |3 online |2 Crossref |b Wiley |c 2019-11-19 |
| 264 | _ | 1 | |3 print |2 Crossref |b Wiley |c 2020-05-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1624272172_1047 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Astrocytes form large networks, in which individual cells are connected via gap junctions. It is thought that this astroglial gap junction coupling contributes to the buffering of extracellular K+ increases. However, it is largely unknown how the control of extracellular K+ by astroglial gap junction coupling depends on the underlying activity patterns and on the magnitude of extracellular K+ increases. We explored this dependency in acute hippocampal slices (CA1, stratum radiatum) by direct K+ -sensitive microelectrode recordings and acute pharmacological inhibition of gap junctions. K+ transients evoked by synaptic and axonal activity were largely unaffected by acute astroglial uncoupling in slices obtained from young and adult rats. Iontophoretic K+ -application enabled us to generate K+ gradients with defined spatial properties and magnitude. By varying the K+ -iontophoresis position and protocol, we found that acute pharmacological uncoupling increases the amplitude of K+ transients once their initial amplitude exceeded ~10 mM. Our experiments demonstrate that the contribution of gap junction coupling to buffering of extracellular K+ gradients is limited to large and localized K+ increases. |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 0 |
| 542 | _ | _ | |i 2019-11-19 |2 Crossref |u http://creativecommons.org/licenses/by/4.0/ |
| 542 | _ | _ | |i 2019-11-19 |2 Crossref |u http://doi.wiley.com/10.1002/tdm_license_1.1 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Astrocytes: metabolism |2 MeSH |
| 650 | _ | 2 | |a CA1 Region, Hippocampal: metabolism |2 MeSH |
| 650 | _ | 2 | |a Gap Junctions: metabolism |2 MeSH |
| 650 | _ | 2 | |a Membrane Potentials: physiology |2 MeSH |
| 650 | _ | 2 | |a Neurons: metabolism |2 MeSH |
| 650 | _ | 2 | |a Potassium: metabolism |2 MeSH |
| 650 | _ | 2 | |a Rats |2 MeSH |
| 650 | _ | 2 | |a Rats, Wistar |2 MeSH |
| 650 | _ | 2 | |a Synapses: metabolism |2 MeSH |
| 700 | 1 | _ | |a Kautzmann, Steffen |b 1 |
| 700 | 1 | _ | |a Boehlen, Anne |b 2 |
| 700 | 1 | _ | |a Steinhäuser, Christian |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Henneberger, Christian |0 P:(DE-2719)2811625 |b 4 |e Last author |u dzne |
| 773 | 1 | 8 | |a 10.1002/glia.23751 |b : Wiley, 2019-11-19 |n 5 |p 918-931 |3 journal-article |2 Crossref |t Glia |v 68 |y 2019 |x 0894-1491 |
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| 856 | 4 | _ | |y OpenAccess |u https://pub.dzne.de/record/141697/files/1574.pdf |
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| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1098/rstb.2013.0600 |2 Crossref |o 10.1098/rstb.2013.0600 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neuroimage.2014.10.012 |2 Crossref |o 10.1016/j.neuroimage.2014.10.012 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.nbd.2016.12.017 |2 Crossref |o 10.1016/j.nbd.2016.12.017 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/brain/awv067 |2 Crossref |o 10.1093/brain/awv067 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/s41467-017-01615-z |2 Crossref |o 10.1038/s41467-017-01615-z |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.2078-10.2010 |2 Crossref |o 10.1523/JNEUROSCI.2078-10.2010 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.0015-14.2014 |2 Crossref |o 10.1523/JNEUROSCI.0015-14.2014 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neuron.2017.08.022 |2 Crossref |o 10.1016/j.neuron.2017.08.022 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1152/jn.00240.2001 |2 Crossref |o 10.1152/jn.00240.2001 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.eplepsyres.2018.04.005 |2 Crossref |o 10.1016/j.eplepsyres.2018.04.005 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.0723-07.2007 |2 Crossref |o 10.1523/JNEUROSCI.0723-07.2007 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neuroscience.2015.01.051 |2 Crossref |o 10.1016/j.neuroscience.2015.01.051 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1242/dev.155275 |2 Crossref |o 10.1242/dev.155275 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nrn2757 |2 Crossref |o 10.1038/nrn2757 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/cercor/bhu157 |2 Crossref |o 10.1093/cercor/bhu157 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/glia.21205 |2 Crossref |o 10.1002/glia.21205 |
| 999 | C | 5 | |y 2001 |2 Crossref |o Harks E. G. A. 2001 |
| 999 | C | 5 | |y 1977 |2 Crossref |o Heinemann U. 1977 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/0006-8993(77)90903-9 |2 Crossref |o 10.1016/0006-8993(77)90903-9 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nprot.2012.140 |2 Crossref |o 10.1038/nprot.2012.140 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/glia.22793 |2 Crossref |o 10.1002/glia.22793 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neuroscience.2004.06.008 |2 Crossref |o 10.1016/j.neuroscience.2004.06.008 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/glia.22629 |2 Crossref |o 10.1002/glia.22629 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.4161/19336950.2014.970448 |2 Crossref |o 10.4161/19336950.2014.970448 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/BF00235028 |2 Crossref |o 10.1007/BF00235028 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.brainresrev.2009.12.001 |2 Crossref |o 10.1016/j.brainresrev.2009.12.001 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1097/00001756-199805110-00008 |2 Crossref |o 10.1097/00001756-199805110-00008 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.2204-16.2017 |2 Crossref |o 10.1523/JNEUROSCI.2204-16.2017 |
| 999 | C | 5 | |y 2017 |2 Crossref |o Minge D. 2017 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S0306-4522(98)00191-2 |2 Crossref |o 10.1016/S0306-4522(98)00191-2 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1126/science.6474173 |2 Crossref |o 10.1126/science.6474173 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1017/S0952523807070472 |2 Crossref |o 10.1017/S0952523807070472 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nn.3662 |2 Crossref |o 10.1038/nn.3662 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.1016650108 |2 Crossref |o 10.1073/pnas.1016650108 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1111/j.1469-7793.2000.00427.x |2 Crossref |o 10.1111/j.1469-7793.2000.00427.x |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/s11064-017-2246-4 |2 Crossref |o 10.1007/s11064-017-2246-4 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1126/science.1164022 |2 Crossref |o 10.1126/science.1164022 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1113/jphysiol.2003.053439 |2 Crossref |o 10.1113/jphysiol.2003.053439 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1097/WNP.0b013e31818e8010 |2 Crossref |o 10.1097/WNP.0b013e31818e8010 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.3790-08.2009 |2 Crossref |o 10.1523/JNEUROSCI.3790-08.2009 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1113/jphysiol.2013.261735 |2 Crossref |o 10.1113/jphysiol.2013.261735 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.23-27-09254.2003 |2 Crossref |o 10.1523/JNEUROSCI.23-27-09254.2003 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1152/physrev.2001.81.3.1065 |2 Crossref |o 10.1152/physrev.2001.81.3.1065 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/glia.21169 |2 Crossref |o 10.1002/glia.21169 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neuint.2007.04.007 |2 Crossref |o 10.1016/j.neuint.2007.04.007 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/0014-4886(74)90097-1 |2 Crossref |o 10.1016/0014-4886(74)90097-1 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.23-03-00766.2003 |2 Crossref |o 10.1523/JNEUROSCI.23-03-00766.2003 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1152/jn.00060.2009 |2 Crossref |o 10.1152/jn.00060.2009 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1152/jn.00148.2004 |2 Crossref |o 10.1152/jn.00148.2004 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.0037-06.2006 |2 Crossref |o 10.1523/JNEUROSCI.0037-06.2006 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1117/1.NPh.4.1.015002 |2 Crossref |o 10.1117/1.NPh.4.1.015002 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.3176-18.2019 |2 Crossref |o 10.1523/JNEUROSCI.3176-18.2019 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1152/jn.2000.83.3.1443 |2 Crossref |o 10.1152/jn.2000.83.3.1443 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.nbd.2009.01.010 |2 Crossref |o 10.1016/j.nbd.2009.01.010 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.conb.2010.06.005 |2 Crossref |o 10.1016/j.conb.2010.06.005 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.2810-05.2005 |2 Crossref |o 10.1523/JNEUROSCI.2810-05.2005 |
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