000144529 001__ 144529
000144529 005__ 20230808104659.0
000144529 0247_ $$2doi$$a10.1117/12.2032813
000144529 037__ $$aDZNE-2020-00066
000144529 1001_ $$aCimalla, Peter$$b0
000144529 1112_ $$aEuropean Conferences on Biomedical Optics$$cMunich$$d2013-05-12 - 2013-05-16$$wGermany
000144529 245__ $$aMagnetomotive imaging of iron oxide nanoparticles as cellular contrast agents for optical coherence tomography
000144529 260__ $$c2013
000144529 3367_ $$2DRIVER$$aconferenceObject
000144529 3367_ $$0PUB:(DE-HGF)26$$2PUB:(DE-HGF)$$aProceedings$$bproc$$mproc$$s1691484372_15419
000144529 3367_ $$2DataCite$$aOutput Types/Book
000144529 3367_ $$2ORCID$$aBOOK
000144529 3367_ $$03$$2EndNote$$aConference Proceedings
000144529 3367_ $$2BibTeX$$aPROCEEDINGS
000144529 520__ $$aRecent studies in animal models provided proof-of-principle evidence for cell transplantation as a potential future therapeutic approach for retinal pathologies in humans such as Retinitis pigmentosa or age-related macular degeneration. In this case, donor cells are injected into the eye in order to protect or replace degenerating photoreceptors or retinal pigment epithelium. However, currently there is no three-dimensional imaging technique available that allows tracking of cell migration and integration into the host tissue under in vivo conditions. Therefore, we investigate about magnetomotive optical coherence tomography (OCT) of substances labeled with iron oxide nanoparticles as a potential method for noninvasive, three-dimensional cell tracking in the retina. We use a self-developed spectral domain OCT system for high-resolution imaging in the 800 nm-wavelength region. A suitable AC magnetic field for magnetomotive imaging was generated using two different setups, which consist of an electrically driven solenoid in combination with a permanent magnet, and a mechanically driven all-permanent magnet configuration. In the sample region the maximum magnetic flux density was 100 mT for both setups, with a field gradient of 9 T/m and 13 T/m for the solenoid and the allpermanent magnet setup, respectively. Magnetomotive OCT imaging was performed in elastic tissue phantoms and single cells labeled with iron oxide nanoparticles. Particle-induced sub-resolution movement of the elastic samples and the single cells could successfully be detected and visualized by means of phase-resolved Doppler OCT analysis. Therefore, this method is a potential technique to enhance image contrast of specific cells in OCT.
000144529 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
000144529 588__ $$aDataset connected to CrossRef Conference
000144529 7001_ $$aBouma, Brett E.$$b1$$eEditor
000144529 7001_ $$aLeitgeb, Rainer A.$$b2$$eEditor
000144529 7001_ $$aWerner, Theresa$$b3
000144529 7001_ $$aGaertner, Maria$$b4
000144529 7001_ $$aMueller, Claudia$$b5
000144529 7001_ $$0P:(DE-HGF)0$$aWalther, Julia$$b6
000144529 7001_ $$aWittig, Dierk$$b7
000144529 7001_ $$aAder, Marius$$b8
000144529 7001_ $$0P:(DE-2719)2000041$$aKarl, Mike$$b9$$udzne
000144529 7001_ $$aKoch, Edmund$$b10
000144529 773__ $$a10.1117/12.2032813
000144529 8564_ $$uhttps://www.spiedigitallibrary.org/conference-proceedings-of-spie/8802/1/Magnetomotive-imaging-of-iron-oxide-nanoparticles-as-cellular-contrast-agents/10.1117/12.2032813.short
000144529 909CO $$ooai:pub.dzne.de:144529$$pVDB
000144529 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000041$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b9$$kDZNE
000144529 9131_ $$0G:(DE-HGF)POF3-342$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vDisease Mechanisms and Model Systems$$x0
000144529 9141_ $$y2013
000144529 9201_ $$0I:(DE-2719)1710004$$kAG Karl$$lRetina Regeneration and Degeneration$$x0
000144529 980__ $$aproc
000144529 980__ $$aVDB
000144529 980__ $$aI:(DE-2719)1710004
000144529 980__ $$aUNRESTRICTED