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@PROCEEDINGS{Cimalla:144529,
      author       = {Cimalla, Peter and Werner, Theresa and Gaertner, Maria and
                      Mueller, Claudia and Walther, Julia and Wittig, Dierk and
                      Ader, Marius and Karl, Mike and Koch, Edmund},
      editor       = {Bouma, Brett E. and Leitgeb, Rainer A.},
      title        = {{M}agnetomotive imaging of iron oxide nanoparticles as
                      cellular contrast agents for optical coherence tomography},
      reportid     = {DZNE-2020-00066},
      year         = {2013},
      abstract     = {Recent studies in animal models provided proof-of-principle
                      evidence for cell transplantation as a potential future
                      therapeutic approach for retinal pathologies in humans such
                      as Retinitis pigmentosa or age-related macular degeneration.
                      In this case, donor cells are injected into the eye in order
                      to protect or replace degenerating photoreceptors or retinal
                      pigment epithelium. However, currently there is no
                      three-dimensional imaging technique available that allows
                      tracking of cell migration and integration into the host
                      tissue under in vivo conditions. Therefore, we investigate
                      about magnetomotive optical coherence tomography (OCT) of
                      substances labeled with iron oxide nanoparticles as a
                      potential method for noninvasive, three-dimensional cell
                      tracking in the retina. We use a self-developed spectral
                      domain OCT system for high-resolution imaging in the 800
                      nm-wavelength region. A suitable AC magnetic field for
                      magnetomotive imaging was generated using two different
                      setups, which consist of an electrically driven solenoid in
                      combination with a permanent magnet, and a mechanically
                      driven all-permanent magnet configuration. In the sample
                      region the maximum magnetic flux density was 100 mT for both
                      setups, with a field gradient of 9 T/m and 13 T/m for the
                      solenoid and the allpermanent magnet setup, respectively.
                      Magnetomotive OCT imaging was performed in elastic tissue
                      phantoms and single cells labeled with iron oxide
                      nanoparticles. Particle-induced sub-resolution movement of
                      the elastic samples and the single cells could successfully
                      be detected and visualized by means of phase-resolved
                      Doppler OCT analysis. Therefore, this method is a potential
                      technique to enhance image contrast of specific cells in
                      OCT.},
      month         = {May},
      date          = {2013-05-12},
      organization  = {European Conferences on Biomedical
                       Optics, Munich (Germany), 12 May 2013 -
                       16 May 2013},
      cin          = {AG Karl},
      cid          = {I:(DE-2719)1710004},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)26},
      doi          = {10.1117/12.2032813},
      url          = {https://pub.dzne.de/record/144529},
}