000144578 001__ 144578
000144578 005__ 20220601114153.0
000144578 0247_ $$2doi$$a10.1007/978-1-4614-1025-6_43
000144578 037__ $$aDZNE-2020-00090
000144578 1001_ $$0P:(DE-HGF)0$$aHatfield, Dolph L.$$b0$$eEditor
000144578 245__ $$aMouse Models for Glutathione Peroxidase 4 (GPx4)
000144578 260__ $$aNew York, NY$$bSpringer New York$$c2012
000144578 29510 $$aSelenium / Hatfield, Dolph L. (Editor)   ; New York, NY : Springer New York, 2012, Chapter 43 ; ISBN: 978-1-4614-1024-9 ; doi:10.1007/978-1-4614-1025-6
000144578 300__ $$a547-559
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000144578 3367_ $$0PUB:(DE-HGF)7$$2PUB:(DE-HGF)$$aContribution to a book$$bcontb$$mcontb$$s1654076492_17981
000144578 520__ $$aThe selenoperoxidase glutathione peroxidase 4 (GPx4 – also frequently referred to as phospholipid hydroperoxide glutathione peroxidase, PHGPx) is one of the eight glutathione peroxidases in mammals, but the only one known to be essential for early mouse development. GPx4 is emerging as one of the most central selenoproteins, and thus has attracted considerable interest in recent years. Key insights into GPx4 function came from the numerous transgenic and knockout mouse studies performed mainly during the last couple of years, which are summarized here. These investigations not only firmly established a crucial role for GPx4 in male fertility and neuroprotection, but also indicated a major regulatory role of GPx4 in oxidative stress-induced cell death signaling. Beyond this, lipid hydroperoxides (LOOH), downstream of GPx4 inactivation, have been recently shown to control receptor tyrosine kinase (RTK) signaling, thus adding a new layer of complexity to the multifaceted roles of GPx4 in cell signaling and disease development.
000144578 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
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000144578 7001_ $$0P:(DE-HGF)0$$aBerry, Marla J.$$b1$$eEditor
000144578 7001_ $$0P:(DE-HGF)0$$aGladyshev, Vadim N.$$b2$$eEditor
000144578 7001_ $$0P:(DE-2719)2369795$$aConrad, Marcus$$b3$$eFirst author$$udzne
000144578 773__ $$a10.1007/978-1-4614-1025-6_43
000144578 909CO $$ooai:pub.dzne.de:144578$$pVDB
000144578 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2369795$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b3$$kDZNE
000144578 9131_ $$0G:(DE-HGF)POF3-342$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vDisease Mechanisms and Model Systems$$x0
000144578 9141_ $$y2012
000144578 9201_ $$0I:(DE-2719)1140001$$kAG Wurst$$lGenome Engineering$$x0
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000144578 980__ $$aI:(DE-2719)1140001
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