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000144653 0247_ $$2doi$$a10.1007/978-1-4614-1997-6_9
000144653 037__ $$aDZNE-2020-00165
000144653 1001_ $$aPfaff, Donald W.$$b0$$eEditor
000144653 245__ $$aAdult Neurogenesis
000144653 260__ $$aNew York, NY$$bSpringer New York$$c2013
000144653 29510 $$aNeuroscience in the 21st Century / Pfaff, Donald W. (Editor)   ; New York, NY : Springer New York, 2013, Chapter 9 ; ISBN: 978-1-4614-1996-9 ; doi:10.1007/978-1-4614-1997-6
000144653 300__ $$a161-178
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000144653 520__ $$aAdult neurogenesis is the generation of new neurons in the adult brain. Adult neurogenesis is an exception, as the brain of mammals is non-neurogenic. Rodents and primates have two neurogenic zones, the hippocampus and the olfactory bulb. Lower vertebrates often have many more sites of adult neurogenesis. In the peripheral nervous system, there is high neurogenesis in the olfactory epithelium. Neurogenesis in the olfactory bulb originates from precursor cells in the wall of the lateral ventricle, the subventricular zone. New interneurons in the bulb are produced. In the dentate gyrus of the hippocampus, new excitatory granule cells are generated that add to the mossy fiber tract into hippocampal area CA3. Numerous factors are known to regulate neurogenesis: it seems that adult neurogenesis responds very sensitively to external stimuli. The current hypothesis is that adult hippocampal neurogenesis critically contributes to hippocampal function, allowing life-long adaptation processes. If adult neurogenesis fails, this might contribute to several important diseases, including dementias, major depression and schizophrenia, as well as temporal lobe epilepsy.
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000144653 7001_ $$0P:(DE-2719)2000011$$aKempermann, Gerd$$b1$$eFirst author$$udzne
000144653 773__ $$a10.1007/978-1-4614-1997-6_9
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