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@INBOOK{Pfaff:144653,
author = {Kempermann, Gerd},
editor = {Pfaff, Donald W.},
title = {{A}dult {N}eurogenesis},
address = {New York, NY},
publisher = {Springer New York},
reportid = {DZNE-2020-00165},
pages = {161-178},
year = {2013},
comment = {Neuroscience in the 21st Century / Pfaff, Donald W.
(Editor) ; New York, NY : Springer New York, 2013, Chapter 9
; ISBN: 978-1-4614-1996-9 ; doi:10.1007/978-1-4614-1997-6},
booktitle = {Neuroscience in the 21st Century /
Pfaff, Donald W. (Editor) ; New York,
NY : Springer New York, 2013, Chapter 9
; ISBN: 978-1-4614-1996-9 ;
doi:10.1007/978-1-4614-1997-6},
abstract = {Adult neurogenesis is the generation of new neurons in the
adult brain. Adult neurogenesis is an exception, as the
brain of mammals is non-neurogenic. Rodents and primates
have two neurogenic zones, the hippocampus and the olfactory
bulb. Lower vertebrates often have many more sites of adult
neurogenesis. In the peripheral nervous system, there is
high neurogenesis in the olfactory epithelium. Neurogenesis
in the olfactory bulb originates from precursor cells in the
wall of the lateral ventricle, the subventricular zone. New
interneurons in the bulb are produced. In the dentate gyrus
of the hippocampus, new excitatory granule cells are
generated that add to the mossy fiber tract into hippocampal
area CA3. Numerous factors are known to regulate
neurogenesis: it seems that adult neurogenesis responds very
sensitively to external stimuli. The current hypothesis is
that adult hippocampal neurogenesis critically contributes
to hippocampal function, allowing life-long adaptation
processes. If adult neurogenesis fails, this might
contribute to several important diseases, including
dementias, major depression and schizophrenia, as well as
temporal lobe epilepsy.},
cin = {AG Kempermann 1},
cid = {I:(DE-2719)1710001},
pnm = {342 - Disease Mechanisms and Model Systems (POF3-342)},
pid = {G:(DE-HGF)POF3-342},
typ = {PUB:(DE-HGF)7},
doi = {10.1007/978-1-4614-1997-6_9},
url = {https://pub.dzne.de/record/144653},
}