000144979 001__ 144979
000144979 005__ 20240426115940.0
000144979 0247_ $$2doi$$a10.1038/s41467-019-14026-z
000144979 0247_ $$2pmid$$apmid:31919362
000144979 0247_ $$2pmc$$apmc:PMC6952376
000144979 0247_ $$2altmetric$$aaltmetric:73788587
000144979 037__ $$aDZNE-2020-00343
000144979 041__ $$aEnglish
000144979 082__ $$a500
000144979 1001_ $$aBerdugo-Vega, Gabriel$$b0
000144979 245__ $$aIncreasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life.
000144979 260__ $$a[London]$$bNature Publishing Group UK$$c2020
000144979 264_1 $$2Crossref$$3online$$bSpringer Science and Business Media LLC$$c2020-01-09
000144979 264_1 $$2Crossref$$3print$$bSpringer Science and Business Media LLC$$c2020-12-01
000144979 3367_ $$2DRIVER$$aarticle
000144979 3367_ $$2DataCite$$aOutput Types/Journal article
000144979 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1714050304_4333
000144979 3367_ $$2BibTeX$$aARTICLE
000144979 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000144979 3367_ $$00$$2EndNote$$aJournal Article
000144979 520__ $$aFunctional plasticity of the brain decreases during ageing causing marked deficits in contextual learning, allocentric navigation and episodic memory. Adult neurogenesis is a prime example of hippocampal plasticity promoting the contextualisation of information and dramatically decreases during ageing. We found that a genetically-driven expansion of neural stem cells by overexpression of the cell cycle regulators Cdk4/cyclinD1 compensated the age-related decline in neurogenesis. This triggered an overall inhibitory effect on the trisynaptic hippocampal circuit resulting in a changed profile of CA1 sharp-wave ripples known to underlie memory consolidation. Most importantly, increased neurogenesis rescued the age-related switch from hippocampal to striatal learning strategies by rescuing allocentric navigation and contextual memory. Our study demonstrates that critical aspects of hippocampal function can be reversed in old age, or compensated throughout life, by exploiting the brain's endogenous reserve of neural stem cells.
000144979 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
000144979 542__ $$2Crossref$$i2020-01-09$$uhttps://creativecommons.org/licenses/by/4.0
000144979 588__ $$aDataset connected to CrossRef, PubMed,
000144979 650_7 $$2NLM Chemicals$$aCcnd1 protein, mouse
000144979 650_7 $$0136601-57-5$$2NLM Chemicals$$aCyclin D1
000144979 650_7 $$0EC 2.7.11.22$$2NLM Chemicals$$aCdk4 protein, mouse
000144979 650_7 $$0EC 2.7.11.22$$2NLM Chemicals$$aCyclin-Dependent Kinase 4
000144979 650_2 $$2MeSH$$aAging: physiology
000144979 650_2 $$2MeSH$$aAnimals
000144979 650_2 $$2MeSH$$aCyclin D1: metabolism
000144979 650_2 $$2MeSH$$aCyclin-Dependent Kinase 4: metabolism
000144979 650_2 $$2MeSH$$aFemale
000144979 650_2 $$2MeSH$$aHippocampus: physiology
000144979 650_2 $$2MeSH$$aLearning: physiology
000144979 650_2 $$2MeSH$$aMemory: physiology
000144979 650_2 $$2MeSH$$aMemory Consolidation: physiology
000144979 650_2 $$2MeSH$$aMice
000144979 650_2 $$2MeSH$$aMice, Inbred C57BL
000144979 650_2 $$2MeSH$$aNeural Stem Cells: physiology
000144979 650_2 $$2MeSH$$aNeurogenesis: physiology
000144979 7001_ $$aArias-Gil, Gonzalo$$b1
000144979 7001_ $$aLópez-Fernández, Adrian$$b2
000144979 7001_ $$aArtegiani, Benedetta$$b3
000144979 7001_ $$0P:(DE-HGF)0$$aWasielewska, Joanna M$$b4
000144979 7001_ $$aLee, Chi-Chieh$$b5
000144979 7001_ $$aLippert, Michael T$$b6
000144979 7001_ $$0P:(DE-2719)2000011$$aKempermann, Gerd$$b7$$udzne
000144979 7001_ $$0P:(DE-HGF)0$$aTakagaki, Kentaroh$$b8
000144979 7001_ $$0P:(DE-HGF)0$$aCalegari, Federico$$b9$$eCorresponding author
000144979 77318 $$2Crossref$$3journal-article$$a10.1038/s41467-019-14026-z$$b : Springer Science and Business Media LLC, 2020-01-09$$n1$$p135$$tNature Communications$$v11$$x2041-1723$$y2020
000144979 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-019-14026-z$$gVol. 11, no. 1, p. 135$$n1$$p135$$tNature Communications$$v11$$x2041-1723$$y2020
000144979 8564_ $$uhttps://pub.dzne.de/record/144979/files/DZNE-2020-00343.pdf$$yOpenAccess
000144979 8564_ $$uhttps://pub.dzne.de/record/144979/files/DZNE-2020-00343.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000144979 909CO $$ooai:pub.dzne.de:144979$$popenaire$$popen_access$$pVDB$$pdriver$$pdnbdelivery
000144979 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000011$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b7$$kDZNE
000144979 9131_ $$0G:(DE-HGF)POF3-342$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vDisease Mechanisms and Model Systems$$x0
000144979 9141_ $$y2020
000144979 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-11
000144979 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2020-01-16
000144979 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2022-11-11
000144979 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2020-01-16
000144979 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-11
000144979 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2022-11-11
000144979 915__ $$0StatID:(DE-HGF)9915$$2StatID$$aIF >= 15$$bNAT COMMUN : 2021$$d2022-11-11
000144979 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNAT COMMUN : 2021$$d2022-11-11
000144979 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2021-10-13T14:44:21Z
000144979 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2021-10-13T14:44:21Z
000144979 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2022-11-11
000144979 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-11
000144979 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-11
000144979 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000144979 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Peer review$$d2021-10-13T14:44:21Z
000144979 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$f2020-01-16
000144979 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences$$d2022-11-11
000144979 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2020-01-16
000144979 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2022-11-11
000144979 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2020-01-16
000144979 9201_ $$0I:(DE-2719)1710001$$kAG Kempermann$$lAdult Neurogenesis$$x0
000144979 980__ $$ajournal
000144979 980__ $$aVDB
000144979 980__ $$aUNRESTRICTED
000144979 980__ $$aI:(DE-2719)1710001
000144979 9801_ $$aFullTexts
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nn.4653$$o10.1038/nn.4653
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0896-6273(02)00830-9$$o10.1016/S0896-6273(02)00830-9
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2014.07.032$$o10.1016/j.neuron.2014.07.032
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.tins.2008.01.002$$o10.1016/j.tins.2008.01.002
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.tins.2013.05.002$$o10.1016/j.tins.2013.05.002
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2011.05.010$$o10.1016/j.neuron.2011.05.010
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1146/annurev-neuro-071013-014134$$o10.1146/annurev-neuro-071013-014134
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.tins.2006.10.002$$o10.1016/j.tins.2006.10.002
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/ejn.12183$$o10.1111/ejn.12183
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2017.06.037$$o10.1016/j.neuron.2017.06.037
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.tins.2015.10.003$$o10.1016/j.tins.2015.10.003
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1017/S1355617702813248$$o10.1017/S1355617702813248
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1037/h0081022$$o10.1037/h0081022
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.23-13-05945.2003$$o10.1523/JNEUROSCI.23-13-05945.2003
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0896-6273(03)00095-3$$o10.1016/S0896-6273(03)00095-3
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.16-06-02027.1996$$o10.1523/JNEUROSCI.16-06-02027.1996
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.2334169100$$o10.1073/pnas.2334169100
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3389/fnsys.2015.00120$$o10.3389/fnsys.2015.00120
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.nlm.2015.10.013$$o10.1016/j.nlm.2015.10.013
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nrn.2017.45$$o10.1038/nrn.2017.45
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.bbr.2019.112112$$o10.1016/j.bbr.2019.112112
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.stem.2012.11.010$$o10.1016/j.stem.2012.11.010
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2016.08.009$$o10.1016/j.neuron.2016.08.009
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s13311-017-0539-6$$o10.1007/s13311-017-0539-6
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1084/jem.20102167$$o10.1084/jem.20102167
000144979 999C5 $$2Crossref$$oP Salomoni 2010$$y2010
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neures.2014.04.004$$o10.1016/j.neures.2014.04.004
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.stem.2009.05.026$$o10.1016/j.stem.2009.05.026
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/emboj.2013.96$$o10.1038/emboj.2013.96
000144979 999C5 $$2Crossref$$o
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cell.2011.05.024$$o10.1016/j.cell.2011.05.024
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.stem.2011.03.010$$o10.1016/j.stem.2011.03.010
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cell.2019.01.040$$o10.1016/j.cell.2019.01.040
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/dvg.20212$$o10.1002/dvg.20212
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.3114-05.2005$$o10.1523/JNEUROSCI.3114-05.2005
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2014.11.023$$o10.1016/j.neuron.2014.11.023
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nn.3260$$o10.1038/nn.3260
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/hipo.20091$$o10.1002/hipo.20091
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/hipo.22013$$o10.1002/hipo.22013
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3389/fncir.2013.00204$$o10.3389/fncir.2013.00204
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/hipo.22557$$o10.1002/hipo.22557
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.3648-05.2006$$o10.1523/JNEUROSCI.3648-05.2006
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nn.2156$$o10.1038/nn.2156
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.1744-05.2005$$o10.1523/JNEUROSCI.1744-05.2005
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nn.4543$$o10.1038/nn.4543
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/hipo.22488$$o10.1002/hipo.22488
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2009.05.013$$o10.1016/j.neuron.2009.05.013
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.bbr.2019.112035$$o10.1016/j.bbr.2019.112035
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1371/journal.pone.0005464$$o10.1371/journal.pone.0005464
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/hipo.22520$$o10.1002/hipo.22520
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0028-3932(02)00157-4$$o10.1016/S0028-3932(02)00157-4
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1101/cshperspect.a021691$$o10.1101/cshperspect.a021691
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/s41593-017-0065-1$$o10.1038/s41593-017-0065-1
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.aat8789$$o10.1126/science.aat8789
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nm.4491$$o10.1038/nm.4491
000144979 999C5 $$2Crossref$$oMM Oh 2016$$y2016
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1046/j.1460-9568.2003.02733.x$$o10.1046/j.1460-9568.2003.02733.x
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nature25975$$o10.1038/nature25975
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.stem.2018.03.015$$o10.1016/j.stem.2018.03.015
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/s41591-019-0375-9$$o10.1038/s41591-019-0375-9
000144979 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.1589772$$o10.1126/science.1589772