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@ARTICLE{BerdugoVega:144979,
      author       = {Berdugo-Vega, Gabriel and Arias-Gil, Gonzalo and
                      López-Fernández, Adrian and Artegiani, Benedetta and
                      Wasielewska, Joanna M and Lee, Chi-Chieh and Lippert,
                      Michael T and Kempermann, Gerd and Takagaki, Kentaroh and
                      Calegari, Federico},
      title        = {{I}ncreasing neurogenesis refines hippocampal activity
                      rejuvenating navigational learning strategies and contextual
                      memory throughout life.},
      journal      = {Nature Communications},
      volume       = {11},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DZNE-2020-00343},
      pages        = {135},
      year         = {2020},
      abstract     = {Functional plasticity of the brain decreases during ageing
                      causing marked deficits in contextual learning, allocentric
                      navigation and episodic memory. Adult neurogenesis is a
                      prime example of hippocampal plasticity promoting the
                      contextualisation of information and dramatically decreases
                      during ageing. We found that a genetically-driven expansion
                      of neural stem cells by overexpression of the cell cycle
                      regulators Cdk4/cyclinD1 compensated the age-related decline
                      in neurogenesis. This triggered an overall inhibitory effect
                      on the trisynaptic hippocampal circuit resulting in a
                      changed profile of CA1 sharp-wave ripples known to underlie
                      memory consolidation. Most importantly, increased
                      neurogenesis rescued the age-related switch from hippocampal
                      to striatal learning strategies by rescuing allocentric
                      navigation and contextual memory. Our study demonstrates
                      that critical aspects of hippocampal function can be
                      reversed in old age, or compensated throughout life, by
                      exploiting the brain's endogenous reserve of neural stem
                      cells.},
      keywords     = {Aging: physiology / Animals / Cyclin D1: metabolism /
                      Cyclin-Dependent Kinase 4: metabolism / Female /
                      Hippocampus: physiology / Learning: physiology / Memory:
                      physiology / Memory Consolidation: physiology / Mice / Mice,
                      Inbred C57BL / Neural Stem Cells: physiology / Neurogenesis:
                      physiology / Ccnd1 protein, mouse (NLM Chemicals) / Cyclin
                      D1 (NLM Chemicals) / Cdk4 protein, mouse (NLM Chemicals) /
                      Cyclin-Dependent Kinase 4 (NLM Chemicals)},
      cin          = {AG Kempermann},
      ddc          = {500},
      cid          = {I:(DE-2719)1710001},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31919362},
      pmc          = {pmc:PMC6952376},
      doi          = {10.1038/s41467-019-14026-z},
      url          = {https://pub.dzne.de/record/144979},
}