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| Home > Publications Database > Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life. > print |
| 001 | 144979 | ||
| 005 | 20240426115940.0 | ||
| 024 | 7 | _ | |a 10.1038/s41467-019-14026-z |2 doi |
| 024 | 7 | _ | |a pmid:31919362 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC6952376 |2 pmc |
| 024 | 7 | _ | |a altmetric:73788587 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-00343 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Berdugo-Vega, Gabriel |b 0 |
| 245 | _ | _ | |a Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life. |
| 260 | _ | _ | |a [London] |c 2020 |b Nature Publishing Group UK |
| 264 | _ | 1 | |3 online |2 Crossref |b Springer Science and Business Media LLC |c 2020-01-09 |
| 264 | _ | 1 | |3 print |2 Crossref |b Springer Science and Business Media LLC |c 2020-12-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1714050304_4333 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Functional plasticity of the brain decreases during ageing causing marked deficits in contextual learning, allocentric navigation and episodic memory. Adult neurogenesis is a prime example of hippocampal plasticity promoting the contextualisation of information and dramatically decreases during ageing. We found that a genetically-driven expansion of neural stem cells by overexpression of the cell cycle regulators Cdk4/cyclinD1 compensated the age-related decline in neurogenesis. This triggered an overall inhibitory effect on the trisynaptic hippocampal circuit resulting in a changed profile of CA1 sharp-wave ripples known to underlie memory consolidation. Most importantly, increased neurogenesis rescued the age-related switch from hippocampal to striatal learning strategies by rescuing allocentric navigation and contextual memory. Our study demonstrates that critical aspects of hippocampal function can be reversed in old age, or compensated throughout life, by exploiting the brain's endogenous reserve of neural stem cells. |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 0 |
| 542 | _ | _ | |i 2020-01-09 |2 Crossref |u https://creativecommons.org/licenses/by/4.0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Ccnd1 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Cyclin D1 |0 136601-57-5 |2 NLM Chemicals |
| 650 | _ | 7 | |a Cdk4 protein, mouse |0 EC 2.7.11.22 |2 NLM Chemicals |
| 650 | _ | 7 | |a Cyclin-Dependent Kinase 4 |0 EC 2.7.11.22 |2 NLM Chemicals |
| 650 | _ | 2 | |a Aging: physiology |2 MeSH |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Cyclin D1: metabolism |2 MeSH |
| 650 | _ | 2 | |a Cyclin-Dependent Kinase 4: metabolism |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Hippocampus: physiology |2 MeSH |
| 650 | _ | 2 | |a Learning: physiology |2 MeSH |
| 650 | _ | 2 | |a Memory: physiology |2 MeSH |
| 650 | _ | 2 | |a Memory Consolidation: physiology |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Mice, Inbred C57BL |2 MeSH |
| 650 | _ | 2 | |a Neural Stem Cells: physiology |2 MeSH |
| 650 | _ | 2 | |a Neurogenesis: physiology |2 MeSH |
| 700 | 1 | _ | |a Arias-Gil, Gonzalo |b 1 |
| 700 | 1 | _ | |a López-Fernández, Adrian |b 2 |
| 700 | 1 | _ | |a Artegiani, Benedetta |b 3 |
| 700 | 1 | _ | |a Wasielewska, Joanna M |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Lee, Chi-Chieh |b 5 |
| 700 | 1 | _ | |a Lippert, Michael T |b 6 |
| 700 | 1 | _ | |a Kempermann, Gerd |0 P:(DE-2719)2000011 |b 7 |u dzne |
| 700 | 1 | _ | |a Takagaki, Kentaroh |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Calegari, Federico |0 P:(DE-HGF)0 |b 9 |e Corresponding author |
| 773 | 1 | 8 | |a 10.1038/s41467-019-14026-z |b : Springer Science and Business Media LLC, 2020-01-09 |n 1 |p 135 |3 journal-article |2 Crossref |t Nature Communications |v 11 |y 2020 |x 2041-1723 |
| 773 | _ | _ | |a 10.1038/s41467-019-14026-z |g Vol. 11, no. 1, p. 135 |0 PERI:(DE-600)2553671-0 |n 1 |p 135 |t Nature Communications |v 11 |y 2020 |x 2041-1723 |
| 856 | 4 | _ | |y OpenAccess |u https://pub.dzne.de/record/144979/files/DZNE-2020-00343.pdf |
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| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 7 |6 P:(DE-2719)2000011 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-342 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Disease Mechanisms and Model Systems |x 0 |
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| 920 | 1 | _ | |0 I:(DE-2719)1710001 |k AG Kempermann |l Adult Neurogenesis |x 0 |
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