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@ARTICLE{Herm:144990,
      author       = {Herm, Juliane and Schirdewan, Alexander and Koch, Lydia and
                      Wutzler, Alexander and Fiebach, Jochen B and Endres,
                      Matthias and Kopp, Ute A and Haeusler, Karl Georg},
      title        = {{I}mpact of atrial fibrillation burden on cognitive
                      function after left atrial ablation - {R}esults of the
                      {MACPAF} study.},
      journal      = {Journal of clinical neuroscience},
      volume       = {73},
      issn         = {0967-5868},
      address      = {Burlington, Mass.},
      publisher    = {Harcourt},
      reportid     = {DZNE-2020-00354},
      pages        = {168-172},
      year         = {2020},
      abstract     = {Atrial fibrillation (AF) is associated with cognitive
                      decline and dementia irrespective of AF-related ischemic
                      stroke. We investigated whether AF burden after ablation in
                      patients with symptomatic paroxysmal AF has an impact on
                      cognitive function. After enrolment to the prospective
                      MACPAF study, study patients received an insertable loop
                      recorder (ILR) and underwent serial neurological/cognitive
                      assessment. To compare cognitive function, the delta of
                      baseline and six months test results (Δpre/post) and a
                      score to assess overall cognitive performance were computed.
                      Thirty patients (median age 65 years (IQR 57-69), $40\%$
                      female) were divided into groups according to median AF
                      burden $(<0.5\%$ vs. $≥0.5\%)$ after ablation. Overall
                      cognitive performance did not differ in patients with an AF
                      $burden < 0.5\%$ (median $120\%$ [IQR 100-150]) vs.
                      $≥0.5\%$ (median $120\%$ [IQR 100-160]) within six months
                      after ablation (p = 0.74). Comparing Δpre/post, patients
                      with an AF $burden ≥ 0.5\%$ showed significantly better
                      results in the digit-span backwards test (median + 1 [IQR
                      0 - +2 points]) compared to patients with an AF
                      $burden < 0.5\%$ (median 0 [IQR -1-+1]) six months after
                      ablation (p = 0.03). In patients with an AF
                      $burden < 0.5\%,$ there was a statistical trend towards
                      better results in the RAVLT test (median + 3 [IQR 0-+4];
                      p = 0.08) and the ROC test (median + 3 [IQR -1-+5;
                      p = 0.07) compared to patients with an AF
                      $burden ≥ 0.5\%$ (median -1 [IQR -3-+2] words and median
                      -1 [IQR -5-+2] points, respectively). Therefore, AF burden
                      had no significant impact on cognitive performance within
                      six months after ablation. Clinical Trial Registration:
                      clinicaltrials.gov NCT01061931.},
      keywords     = {Aged / Atrial Fibrillation: complications / Atrial
                      Fibrillation: physiopathology / Atrial Fibrillation: surgery
                      / Catheter Ablation: methods / Cognition / Cognition
                      Disorders: epidemiology / Cognition Disorders: etiology /
                      Female / Humans / Male / Middle Aged / Prospective Studies /
                      Treatment Outcome},
      cin          = {AG Endres},
      ddc          = {610},
      cid          = {I:(DE-2719)1811005},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31992513},
      doi          = {10.1016/j.jocn.2019.12.030},
      url          = {https://pub.dzne.de/record/144990},
}