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@ARTICLE{Samir:145019,
      author       = {Samir, Mohamed and Vidal, Ramon O and Abdallah, Fatma and
                      Capece, Vincenzo and Seehusen, Frauke and Geffers, Robert
                      and Hussein, Ashraf and Ali, Ahmed A H and Bonn, Stefan and
                      Pessler, Frank},
      title        = {{O}rgan-specific small non-coding {RNA} responses in
                      domestic ({S}udani) ducks experimentally infected with
                      highly pathogenic avian influenza virus ({H}5{N}1).},
      journal      = {RNA biology},
      volume       = {17},
      number       = {1},
      issn         = {1547-6286},
      address      = {Philadelphia, Pa.},
      publisher    = {Taylor $\&$ Francis},
      reportid     = {DZNE-2020-00379},
      pages        = {112-124},
      year         = {2020},
      abstract     = {The duck represents an important reservoir of influenza
                      viruses for transmission to other avian and mammalian hosts,
                      including humans. The increased pathogenicity of the
                      recently emerging clades of highly pathogenic avian
                      influenza (HPAI) viruses of the H5N1 subtype in ducks
                      features systemic viral spread and organ-to-organ variation
                      in viral transcription and tissue damage. We previously
                      reported that experimental infection of Sudani ducks
                      (Cairina moschata) with an Egyptian HPAI (H5N1) virus (clade
                      2.2.1.2) features high viral replication and severe tissue
                      damage in lung, but lower viral replication and only mild
                      histological changes in brain. Little is known about the
                      involvement of miRNA in organ-specific responses to H5N1
                      viruses in ducks, and involvement of the other classes of
                      small noncoding RNA (sncRNA) has not been investigated so
                      far. Following RNA sequencing, we have annotated the duck
                      sncRNome and compared global expression changes of the four
                      major sncRNA classes (miRNAs, piRNAs, snoRNAs, snRNAs)
                      between duck lung and brain during a 120 h time course of
                      infection with this HPAI strain. We find major
                      organ-specific differences in miRNA, piRNA and snoRNA
                      populations even before infection and substantial
                      reprogramming of all sncRNA classes throughout infection,
                      which was less pronounced in brain. Pathway prediction
                      analysis of miRNA targets revealed enrichment of
                      inflammation-, infection- and apoptosis-related pathways in
                      lung, but enrichment of metabolism-related pathways
                      (including tryptophan metabolism) in brain. Thus,
                      organ-specific differences in sncRNA responses may
                      contribute to differences in viral replication and organ
                      damage in ducks infected with isolates from this emerging
                      HPAI clade, and likely other strains.},
      keywords     = {Animals / Chromosome Mapping / Ducks: genetics / Ducks:
                      virology / Gene Expression Profiling / Host-Pathogen
                      Interactions: genetics / Influenza A Virus, H5N1 Subtype:
                      pathogenicity / Influenza A Virus, H5N1 Subtype: physiology
                      / Influenza in Birds: genetics / Influenza in Birds:
                      metabolism / Influenza in Birds: virology / MicroRNAs:
                      genetics / Organ Specificity: genetics / RNA, Small
                      Untranslated: genetics},
      cin          = {AG Bonn 1},
      ddc          = {570},
      cid          = {I:(DE-2719)1410003},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31538530},
      pmc          = {pmc:PMC6948974},
      doi          = {10.1080/15476286.2019.1669879},
      url          = {https://pub.dzne.de/record/145019},
}