TY  - JOUR
AU  - Faber, Jennifer
AU  - Giordano, Ilaria
AU  - Jiang, Xueyan
AU  - Kindler, Christine
AU  - Spottke, Annika
AU  - Acosta-Cabronero, Julio
AU  - Nestor, Peter J
AU  - Machts, Judith
AU  - Düzel, Emrah
AU  - Vielhaber, Stefan
AU  - Speck, Oliver
AU  - Dudesek, Ales
AU  - Kamm, Christoph
AU  - Scheef, Lukas
AU  - Klockgether, Thomas
TI  - Prominent White Matter Involvement in Multiple System Atrophy of Cerebellar Type.
JO  - Movement disorders
VL  - 35
IS  - 5
SN  - 0885-3185
CY  - New York, NY
PB  - Wiley
M1  - DZNE-2020-00399
SP  - 816-824
PY  - 2020
AB  - Sporadic degenerative ataxia patients fall into 2 major groups: multiple system atrophy with predominant cerebellar ataxia (MSA-C) and sporadic adult-onset ataxia (SAOA). Both groups have cerebellar volume loss, but little is known about the differential involvement of gray and white matter in MSA-C when compared with SAOA.The objective of this study was to identify structural differences of brain gray and white matter between both patient groups.We used magnetic resonance imaging to acquire T1-weighted images and diffusion tensor images from 12 MSA-C patients, 31 SAOA patients, and 55 healthy controls. Magnetic resonance imaging data were analyzed with voxel-based-morphometry, tract-based spatial statistics, and tractography-based regional diffusion tensor images analysis.Whole-brain and cerebellar-focused voxel-based-morphometry analysis showed gray matter volume loss in both patient groups when compared with healthy controls, specifically in the cerebellar areas subserving sensorimotor functions. When compared with controls, the SAOA and MSA-C patients showed white matter loss in the cerebellum, whereas brainstem white matter was reduced only in the MSA-C patients. The tract-based spatial statistics revealed reduced fractional anisotropy within the pons and cerebellum in the MSA-C patients both in comparison with the SAOA patients and healthy controls. In addition, tractography-based regional analysis showed reduced fractional anisotropy along the corticospinal tracts in MSA-C, but not SAOA.Although in our cohort extent and distribution of gray and white matter loss were similar between the MSA-C and SAOA patients, magnetic resonance imaging data showed prominent microstructural white matter involvement in the MSA-C patients that was not present in the SAOA patients. Our findings highlight the significance of microstructural white matter changes in the differentiation between both conditions. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
KW  - Adult
KW  - Atrophy: pathology
KW  - Cerebellum: diagnostic imaging
KW  - Cerebellum: pathology
KW  - Humans
KW  - Image Processing, Computer-Assisted
KW  - Magnetic Resonance Imaging
KW  - Multiple System Atrophy: diagnostic imaging
KW  - Multiple System Atrophy: pathology
KW  - White Matter: diagnostic imaging
KW  - White Matter: pathology
LB  - PUB:(DE-HGF)16
C6  - pmid:31994808
DO  - DOI:10.1002/mds.27987
UR  - https://pub.dzne.de/record/145039
ER  -