% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Faber:145039,
      author       = {Faber, Jennifer and Giordano, Ilaria and Jiang, Xueyan and
                      Kindler, Christine and Spottke, Annika and Acosta-Cabronero,
                      Julio and Nestor, Peter J and Machts, Judith and Düzel,
                      Emrah and Vielhaber, Stefan and Speck, Oliver and Dudesek,
                      Ales and Kamm, Christoph and Scheef, Lukas and Klockgether,
                      Thomas},
      title        = {{P}rominent {W}hite {M}atter {I}nvolvement in {M}ultiple
                      {S}ystem {A}trophy of {C}erebellar {T}ype.},
      journal      = {Movement disorders},
      volume       = {35},
      number       = {5},
      issn         = {0885-3185},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {DZNE-2020-00399},
      pages        = {816-824},
      year         = {2020},
      abstract     = {Sporadic degenerative ataxia patients fall into 2 major
                      groups: multiple system atrophy with predominant cerebellar
                      ataxia (MSA-C) and sporadic adult-onset ataxia (SAOA). Both
                      groups have cerebellar volume loss, but little is known
                      about the differential involvement of gray and white matter
                      in MSA-C when compared with SAOA.The objective of this study
                      was to identify structural differences of brain gray and
                      white matter between both patient groups.We used magnetic
                      resonance imaging to acquire T1-weighted images and
                      diffusion tensor images from 12 MSA-C patients, 31 SAOA
                      patients, and 55 healthy controls. Magnetic resonance
                      imaging data were analyzed with voxel-based-morphometry,
                      tract-based spatial statistics, and tractography-based
                      regional diffusion tensor images analysis.Whole-brain and
                      cerebellar-focused voxel-based-morphometry analysis showed
                      gray matter volume loss in both patient groups when compared
                      with healthy controls, specifically in the cerebellar areas
                      subserving sensorimotor functions. When compared with
                      controls, the SAOA and MSA-C patients showed white matter
                      loss in the cerebellum, whereas brainstem white matter was
                      reduced only in the MSA-C patients. The tract-based spatial
                      statistics revealed reduced fractional anisotropy within the
                      pons and cerebellum in the MSA-C patients both in comparison
                      with the SAOA patients and healthy controls. In addition,
                      tractography-based regional analysis showed reduced
                      fractional anisotropy along the corticospinal tracts in
                      MSA-C, but not SAOA.Although in our cohort extent and
                      distribution of gray and white matter loss were similar
                      between the MSA-C and SAOA patients, magnetic resonance
                      imaging data showed prominent microstructural white matter
                      involvement in the MSA-C patients that was not present in
                      the SAOA patients. Our findings highlight the significance
                      of microstructural white matter changes in the
                      differentiation between both conditions. © 2020 The
                      Authors. Movement Disorders published by Wiley Periodicals,
                      Inc. on behalf of International Parkinson and Movement
                      Disorder Society.},
      keywords     = {Adult / Atrophy: pathology / Cerebellum: diagnostic imaging
                      / Cerebellum: pathology / Humans / Image Processing,
                      Computer-Assisted / Magnetic Resonance Imaging / Multiple
                      System Atrophy: diagnostic imaging / Multiple System
                      Atrophy: pathology / White Matter: diagnostic imaging /
                      White Matter: pathology},
      cin          = {Patient Studies Bonn / AG Nestor / AG Speck / AG Düzel /
                      AG Boecker},
      ddc          = {610},
      cid          = {I:(DE-2719)1011101 / I:(DE-2719)1310001 /
                      I:(DE-2719)1340009 / I:(DE-2719)5000006 /
                      I:(DE-2719)1011202},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31994808},
      doi          = {10.1002/mds.27987},
      url          = {https://pub.dzne.de/record/145039},
}