TY  - JOUR
AU  - Piot, Ines
AU  - Schweyer, Kerstin
AU  - Respondek, Gesine
AU  - Stamelou, Maria
AU  - Sckopke, Philipp
AU  - Schenk, Thomas
AU  - Goetz, Christopher G
AU  - Stebbins, Glenn T
AU  - Höglinger, Günter
AU  - Gasser, Thomas
AU  - Hermann, Andreas
AU  - Höglinger, Günter
AU  - Höllerhage, Matthias
AU  - Kimmich, Okka
AU  - Klockgether, Thomas
AU  - Levin, Johannes
AU  - Machetanz, Gerrit
AU  - Osterrath, Antje
AU  - Palleis, Carla
AU  - Prudlo, Johannes
AU  - Spottke, Annika
AU  - Berg, Daniela
AU  - Bürk, Katrin
AU  - Claßen, Joseph
AU  - Eggers, Carsten
AU  - Greuel, Andrea
AU  - Grimm, Max-Joseph
AU  - Hermann, Lennard
AU  - Iankova, Vassilena
AU  - Jahn, Klaus
AU  - Jost, Wolfgang
AU  - Klietz, Martin
AU  - Kühn, Andrea
AU  - Marxreiter, Franz
AU  - Paschen, Steffen
AU  - Poetter-Nerger, Monika
AU  - Preisl, Marie-Therese
AU  - Prilop, Lisa
AU  - Tönges, Lars
AU  - Trenkwalder, Claudia
AU  - Warnecke, Tobias
AU  - Wegner, Florian
AU  - Winkler, Jürgen
AU  - Antonini, Angelo
AU  - P, Kailash P
AU  - L, Adam L
AU  - Colosimo, Carlo
AU  - Compta, Yaroslau
AU  - Corvol, Jean-Christophe
AU  - I, Lawrence I
AU  - Höglinger, Günter U
AU  - E, Anthony E
AU  - Litvan, Irene
AU  - R, Huw R
AU  - Nilsson, Christer
AU  - Pantelyat, Alexander
AU  - Respondek, Gesine
AU  - Stamelou, Maria
TI  - The Progressive Supranuclear Palsy Clinical Deficits Scale.
JO  - Movement disorders
VL  - 35
IS  - 4
SN  - 0885-3185
CY  - New York, NY
PB  - Wiley
M1  - DZNE-2020-00406
SP  - 650-661
PY  - 2020
AB  - There is currently no undisputed, validated, clinically meaningful measure for deficits in the broad spectrum of PSP phenotypes.To develop a scale to monitor clinical deficits in patients with PSP across its broad phenotypes.The Progressive Supranuclear Palsy Clinical Deficits Scale was conceptualized to cover seven clinical domains (Akinesia-rigidity, Bradyphrenia, Communication, Dysphagia, Eye movements, Finger dexterity, and Gait </td><td width="150">
AB  -  balance), each scored from 0 to 3 (no, mild, moderate, or severe deficits). User guidelines were developed to standardize its application. Progressive Supranuclear Palsy Clinical Deficits Scale scores were collected in patients fulfilling the MDS-PSP diagnostic criteria in two independent, multicenter, observational studies, both cross-sectionally (exploratory DescribePSP cohort; confirmatory ProPSP cohort) and longitudinally (12-months' follow-up, both cohorts).Cognitive pretesting demonstrated easy scale utility. In total, 164 patients were scored (70.4 ± 7.6 years; 62
KW  - Disease Progression
KW  - Female
KW  - Fingers
KW  - Humans
KW  - Male
KW  - Motor Skills
KW  - Reproducibility of Results
KW  - Supranuclear Palsy, Progressive: diagnosis
LB  - PUB:(DE-HGF)16
C6  - pmid:31951049
DO  - DOI:10.1002/mds.27964
UR  - https://pub.dzne.de/record/145046
ER  -