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@ARTICLE{Piot:145046,
      author       = {Piot, Ines and Schweyer, Kerstin and Respondek, Gesine and
                      Stamelou, Maria and Sckopke, Philipp and Schenk, Thomas and
                      Goetz, Christopher G and Stebbins, Glenn T and Höglinger,
                      Günter and Gasser, Thomas and Hermann, Andreas and
                      Höglinger, Günter and Höllerhage, Matthias and Kimmich,
                      Okka and Klockgether, Thomas and Levin, Johannes and
                      Machetanz, Gerrit and Osterrath, Antje and Palleis, Carla
                      and Prudlo, Johannes and Spottke, Annika and Berg, Daniela
                      and Bürk, Katrin and Claßen, Joseph and Eggers, Carsten
                      and Greuel, Andrea and Grimm, Max-Joseph and Hermann,
                      Lennard and Iankova, Vassilena and Jahn, Klaus and Jost,
                      Wolfgang and Klietz, Martin and Kühn, Andrea and
                      Marxreiter, Franz and Paschen, Steffen and Poetter-Nerger,
                      Monika and Preisl, Marie-Therese and Prilop, Lisa and
                      Tönges, Lars and Trenkwalder, Claudia and Warnecke, Tobias
                      and Wegner, Florian and Winkler, Jürgen and Antonini,
                      Angelo and P, Kailash P and L, Adam L and Colosimo, Carlo
                      and Compta, Yaroslau and Corvol, Jean-Christophe and I,
                      Lawrence I and Höglinger, Günter U and E, Anthony E and
                      Litvan, Irene and R, Huw R and Nilsson, Christer and
                      Pantelyat, Alexander and Respondek, Gesine and Stamelou,
                      Maria},
      collaboration = {group, DescribePSP study and group, ProPSP study and group,
                      MDS-endorsed PSP study},
      title        = {{T}he {P}rogressive {S}upranuclear {P}alsy {C}linical
                      {D}eficits {S}cale.},
      journal      = {Movement disorders},
      volume       = {35},
      number       = {4},
      issn         = {0885-3185},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {DZNE-2020-00406},
      pages        = {650-661},
      year         = {2020},
      abstract     = {There is currently no undisputed, validated, clinically
                      meaningful measure for deficits in the broad spectrum of PSP
                      phenotypes.To develop a scale to monitor clinical deficits
                      in patients with PSP across its broad phenotypes.The
                      Progressive Supranuclear Palsy Clinical Deficits Scale was
                      conceptualized to cover seven clinical domains
                      (Akinesia-rigidity, Bradyphrenia, Communication, Dysphagia,
                      Eye movements, Finger dexterity, and Gait $\&$ balance),
                      each scored from 0 to 3 (no, mild, moderate, or severe
                      deficits). User guidelines were developed to standardize its
                      application. Progressive Supranuclear Palsy Clinical
                      Deficits Scale scores were collected in patients fulfilling
                      the MDS-PSP diagnostic criteria in two independent,
                      multicenter, observational studies, both cross-sectionally
                      (exploratory DescribePSP cohort; confirmatory ProPSP cohort)
                      and longitudinally (12-months' follow-up, both
                      cohorts).Cognitive pretesting demonstrated easy scale
                      utility. In total, 164 patients were scored
                      (70.4 ± 7.6 years; $62\%$ males, $35\%$ variant
                      phenotypes). Mean Progressive Supranuclear Palsy Clinical
                      Deficits Scale completion time was 4 minutes. The
                      Progressive Supranuclear Palsy Clinical Deficits Scale total
                      score correlated with existing scales (e.g., Progressive
                      Supranuclear Palsy Rating Scale: R = 0.88; P < 0.001).
                      Individual Progressive Supranuclear Palsy Clinical Deficits
                      Scale items correlated well with similar constructs in
                      existing scales. Internal consistency (Cronbach's alpha:
                      0.75), inter-rater reliability (0.96), and test-retest
                      stability (0.99) were acceptable. The PSP-CDS showed
                      significant 12-month change (baseline, 8.6 ± 3.6;
                      follow-up: 10.8 ± 3.6; annualized difference:
                      3.4 ± 3.4; n = 49; P < 0.0001). Sample sizes required
                      per arm for a two-arm, 1-year follow-up therapeutic trial to
                      detect $50\%$ change in Progressive Supranuclear Palsy
                      Clinical Deficits Scale progression was estimated to be 65
                      (two-sided, two-sample t test).The Progressive Supranuclear
                      Palsy Clinical Deficits Scale is a rapidly completed,
                      clinimetrically sound scale for clinical care and research
                      involving PSP. © 2020 International Parkinson and Movement
                      Disorder Society.},
      keywords     = {Disease Progression / Female / Fingers / Humans / Male /
                      Motor Skills / Reproducibility of Results / Supranuclear
                      Palsy, Progressive: diagnosis},
      cin          = {AG Höglinger},
      ddc          = {610},
      cid          = {I:(DE-2719)1110002},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31951049},
      doi          = {10.1002/mds.27964},
      url          = {https://pub.dzne.de/record/145046},
}