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| 001 | 145046 | ||
| 005 | 20250415092455.0 | ||
| 024 | 7 | _ | |a 10.1002/mds.27964 |2 doi |
| 024 | 7 | _ | |a pmid:31951049 |2 pmid |
| 024 | 7 | _ | |a 0885-3185 |2 ISSN |
| 024 | 7 | _ | |a 1531-8257 |2 ISSN |
| 024 | 7 | _ | |a altmetric:74188526 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-00406 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Piot, Ines |0 P:(DE-2719)9000949 |b 0 |e First author |u dzne |
| 245 | _ | _ | |a The Progressive Supranuclear Palsy Clinical Deficits Scale. |
| 260 | _ | _ | |a New York, NY |c 2020 |b Wiley |
| 264 | _ | 1 | |3 online |2 Crossref |b Wiley |c 2020-01-17 |
| 264 | _ | 1 | |3 print |2 Crossref |b Wiley |c 2020-04-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1744701853_3743 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a There is currently no undisputed, validated, clinically meaningful measure for deficits in the broad spectrum of PSP phenotypes.To develop a scale to monitor clinical deficits in patients with PSP across its broad phenotypes.The Progressive Supranuclear Palsy Clinical Deficits Scale was conceptualized to cover seven clinical domains (Akinesia-rigidity, Bradyphrenia, Communication, Dysphagia, Eye movements, Finger dexterity, and Gait & balance), each scored from 0 to 3 (no, mild, moderate, or severe deficits). User guidelines were developed to standardize its application. Progressive Supranuclear Palsy Clinical Deficits Scale scores were collected in patients fulfilling the MDS-PSP diagnostic criteria in two independent, multicenter, observational studies, both cross-sectionally (exploratory DescribePSP cohort; confirmatory ProPSP cohort) and longitudinally (12-months' follow-up, both cohorts).Cognitive pretesting demonstrated easy scale utility. In total, 164 patients were scored (70.4 ± 7.6 years; 62% males, 35% variant phenotypes). Mean Progressive Supranuclear Palsy Clinical Deficits Scale completion time was 4 minutes. The Progressive Supranuclear Palsy Clinical Deficits Scale total score correlated with existing scales (e.g., Progressive Supranuclear Palsy Rating Scale: R = 0.88; P < 0.001). Individual Progressive Supranuclear Palsy Clinical Deficits Scale items correlated well with similar constructs in existing scales. Internal consistency (Cronbach's alpha: 0.75), inter-rater reliability (0.96), and test-retest stability (0.99) were acceptable. The PSP-CDS showed significant 12-month change (baseline, 8.6 ± 3.6; follow-up: 10.8 ± 3.6; annualized difference: 3.4 ± 3.4; n = 49; P < 0.0001). Sample sizes required per arm for a two-arm, 1-year follow-up therapeutic trial to detect 50% change in Progressive Supranuclear Palsy Clinical Deficits Scale progression was estimated to be 65 (two-sided, two-sample t test).The Progressive Supranuclear Palsy Clinical Deficits Scale is a rapidly completed, clinimetrically sound scale for clinical care and research involving PSP. © 2020 International Parkinson and Movement Disorder Society. |
| 536 | _ | _ | |a 344 - Clinical and Health Care Research (POF3-344) |0 G:(DE-HGF)POF3-344 |c POF3-344 |f POF III |x 0 |
| 542 | _ | _ | |i 2020-01-17 |2 Crossref |u http://onlinelibrary.wiley.com/termsAndConditions#vor |
| 542 | _ | _ | |i 2020-01-17 |2 Crossref |u http://doi.wiley.com/10.1002/tdm_license_1.1 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 2 | |a Disease Progression |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Fingers |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Motor Skills |2 MeSH |
| 650 | _ | 2 | |a Reproducibility of Results |2 MeSH |
| 650 | _ | 2 | |a Supranuclear Palsy, Progressive: diagnosis |2 MeSH |
| 700 | 1 | _ | |a Schweyer, Kerstin |0 P:(DE-2719)2811446 |b 1 |u dzne |
| 700 | 1 | _ | |a Respondek, Gesine |0 P:(DE-2719)2811600 |b 2 |u dzne |
| 700 | 1 | _ | |a Stamelou, Maria |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a group, DescribePSP study |0 P:(DE-HGF)0 |b 4 |e Collaboration Author |
| 700 | 1 | _ | |a group, ProPSP study |0 P:(DE-HGF)0 |b 5 |e Collaboration Author |
| 700 | 1 | _ | |a group, MDS-endorsed PSP study |0 P:(DE-HGF)0 |b 6 |e Collaboration Author |
| 700 | 1 | _ | |a Sckopke, Philipp |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Schenk, Thomas |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Goetz, Christopher G |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a Stebbins, Glenn T |0 P:(DE-HGF)0 |b 10 |
| 700 | 1 | _ | |a Höglinger, Günter |0 P:(DE-2719)2811373 |b 11 |e Last author |u dzne |
| 700 | 1 | _ | |a Gasser, Thomas |0 P:(DE-HGF)0 |b 12 |
| 700 | 1 | _ | |a Hermann, Andreas |0 P:(DE-HGF)0 |b 13 |
| 700 | 1 | _ | |a Höglinger, Günter |0 P:(DE-HGF)0 |b 14 |
| 700 | 1 | _ | |a Höllerhage, Matthias |0 P:(DE-HGF)0 |b 15 |
| 700 | 1 | _ | |a Kimmich, Okka |0 P:(DE-HGF)0 |b 16 |
| 700 | 1 | _ | |a Klockgether, Thomas |0 P:(DE-HGF)0 |b 17 |
| 700 | 1 | _ | |a Levin, Johannes |0 P:(DE-HGF)0 |b 18 |
| 700 | 1 | _ | |a Machetanz, Gerrit |0 P:(DE-HGF)0 |b 19 |
| 700 | 1 | _ | |a Osterrath, Antje |0 P:(DE-HGF)0 |b 20 |
| 700 | 1 | _ | |a Palleis, Carla |0 P:(DE-HGF)0 |b 21 |
| 700 | 1 | _ | |a Prudlo, Johannes |0 P:(DE-HGF)0 |b 22 |
| 700 | 1 | _ | |a Spottke, Annika |0 P:(DE-HGF)0 |b 23 |
| 700 | 1 | _ | |a Berg, Daniela |0 P:(DE-HGF)0 |b 24 |
| 700 | 1 | _ | |a Bürk, Katrin |b 25 |
| 700 | 1 | _ | |a Claßen, Joseph |b 26 |
| 700 | 1 | _ | |a Eggers, Carsten |b 27 |
| 700 | 1 | _ | |a Greuel, Andrea |b 28 |
| 700 | 1 | _ | |a Grimm, Max-Joseph |0 P:(DE-HGF)0 |b 29 |
| 700 | 1 | _ | |a Hermann, Lennard |b 30 |
| 700 | 1 | _ | |a Iankova, Vassilena |b 31 |
| 700 | 1 | _ | |a Jahn, Klaus |b 32 |
| 700 | 1 | _ | |a Jost, Wolfgang |b 33 |
| 700 | 1 | _ | |a Klietz, Martin |b 34 |
| 700 | 1 | _ | |a Kühn, Andrea |0 P:(DE-HGF)0 |b 35 |
| 700 | 1 | _ | |a Marxreiter, Franz |b 36 |
| 700 | 1 | _ | |a Paschen, Steffen |b 37 |
| 700 | 1 | _ | |a Poetter-Nerger, Monika |b 38 |
| 700 | 1 | _ | |a Preisl, Marie-Therese |b 39 |
| 700 | 1 | _ | |a Prilop, Lisa |b 40 |
| 700 | 1 | _ | |a Tönges, Lars |b 41 |
| 700 | 1 | _ | |a Trenkwalder, Claudia |b 42 |
| 700 | 1 | _ | |a Warnecke, Tobias |b 43 |
| 700 | 1 | _ | |a Wegner, Florian |b 44 |
| 700 | 1 | _ | |a Winkler, Jürgen |b 45 |
| 700 | 1 | _ | |a Antonini, Angelo |b 46 |
| 700 | 1 | _ | |a P, Kailash P |b 47 |
| 700 | 1 | _ | |a L, Adam L |b 48 |
| 700 | 1 | _ | |a Colosimo, Carlo |b 49 |
| 700 | 1 | _ | |a Compta, Yaroslau |b 50 |
| 700 | 1 | _ | |a Corvol, Jean-Christophe |b 51 |
| 700 | 1 | _ | |a I, Lawrence I |b 52 |
| 700 | 1 | _ | |a Höglinger, Günter U |0 P:(DE-HGF)0 |b 53 |
| 700 | 1 | _ | |a E, Anthony E |b 54 |
| 700 | 1 | _ | |a Litvan, Irene |b 55 |
| 700 | 1 | _ | |a R, Huw R |b 56 |
| 700 | 1 | _ | |a Nilsson, Christer |b 57 |
| 700 | 1 | _ | |a Pantelyat, Alexander |b 58 |
| 700 | 1 | _ | |a Respondek, Gesine |0 P:(DE-HGF)0 |b 59 |
| 700 | 1 | _ | |a Stamelou, Maria |b 60 |
| 773 | 1 | 8 | |a 10.1002/mds.27964 |b : Wiley, 2020-01-17 |n 4 |p 650-661 |3 journal-article |2 Crossref |t Movement Disorders |v 35 |y 2020 |x 0885-3185 |
| 773 | _ | _ | |a 10.1002/mds.27964 |g Vol. 35, no. 4, p. 650 - 661 |0 PERI:(DE-600)2041249-6 |n 4 |p 650-661 |t Movement disorders |v 35 |y 2020 |x 0885-3185 |
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