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000145054 1001_ $$0P:(DE-HGF)0$$aKaut, Oliver$$b0$$eCorresponding author
000145054 245__ $$aResting-state fMRI reveals increased functional connectivity in the cerebellum but decreased functional connectivity of the caudate nucleus in Parkinson's disease.
000145054 260__ $$aAbingdon, Oxon$$bTaylor & Francis$$c2020
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000145054 520__ $$aObjective: Frequent falls are common in Parkinson's disease (PD). Resting-state fMRI (rs-fMRI) studies have found differences in functional connectivity between PD patients and healthy controls. However, whether functional connectivity in PD patients with frequent falls (PD-fallers) differs from those without falls (PD-non fallers) is unknown. Therefore, to elucidate the underlying mechanisms leading to postural instability in PD patients with frequent falls, we compared changes in functional connectivity between PD-fallers, PD-non fallers and healthy controls.Methods: Thirteen healthy controls (70.7 ± 7.2 years) were compared to thirteen PD-fallers (70.6 ± 5.9 years) and 19 PD-non fallers (71.61 ± 5.8 years) without cognitive impairment. We performed 1.5T rs-fMRI scans and evaluated gait and balance, motor symptoms and cognitive functions.Results: Cerebellar seed regions showed increased functional connectivity in PD-fallers compared to controls in two connections between the cerebellar cortex and vermis (p-value = 0.02). Conversely, in comparison to controls, functional connectivity between the precuneus and caudate nucleus was decreased in PD-non fallers (p-value = 0.015). A similar trend was also observed between controls and PD-fallers, although this difference did not reach statistical significance.Discussion: We found increased functional connectivity among cerebellar structures in PD, which may reflect an adaptive (compensatory) mechanism through activation of additional brain structures to restore gait function. In contrast, a relative disconnection between the precuneus and caudate nucleus in PD patients might indicate an impaired brain network unrelated to the risk of falls. Cerebellar areas might thus be considered as future therapeutic targets for neuromodulatory treatment of postural instability in PD.Abbreviations: DMN: default mode network; FC: functional connectivity; IPL: inferior parietal lobule; MMSE: Minimal Mental Status Examination; PD: Parkinson's disease; rs-fMRI: resting-state functional Magnetic Resonance Imaging; UPDRSIII: Unified Parkinson's disease ranking scale.
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000145054 650_2 $$2MeSH$$aAged
000145054 650_2 $$2MeSH$$aCaudate Nucleus: diagnostic imaging
000145054 650_2 $$2MeSH$$aCaudate Nucleus: physiopathology
000145054 650_2 $$2MeSH$$aCerebellum: diagnostic imaging
000145054 650_2 $$2MeSH$$aCerebellum: physiopathology
000145054 650_2 $$2MeSH$$aCohort Studies
000145054 650_2 $$2MeSH$$aFemale
000145054 650_2 $$2MeSH$$aFollow-Up Studies
000145054 650_2 $$2MeSH$$aHumans
000145054 650_2 $$2MeSH$$aMagnetic Resonance Imaging: methods
000145054 650_2 $$2MeSH$$aMale
000145054 650_2 $$2MeSH$$aNerve Net: diagnostic imaging
000145054 650_2 $$2MeSH$$aNerve Net: physiopathology
000145054 650_2 $$2MeSH$$aParkinson Disease: diagnostic imaging
000145054 650_2 $$2MeSH$$aParkinson Disease: physiopathology
000145054 650_2 $$2MeSH$$aRest
000145054 7001_ $$0P:(DE-HGF)0$$aMielacher, Clemens$$b1
000145054 7001_ $$0P:(DE-HGF)0$$aHurlemann, René$$b2
000145054 7001_ $$0P:(DE-2719)2000056$$aWüllner, Ullrich$$b3$$eLast author$$udzne
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000145054 773__ $$0PERI:(DE-600)2074874-7$$a10.1080/01616412.2019.1709141$$gVol. 42, no. 1, p. 62 - 67$$n1$$p62-67$$tNeurological research$$v42$$x0161-6412$$y2020
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