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@ARTICLE{Kaut:145054,
      author       = {Kaut, Oliver and Mielacher, Clemens and Hurlemann, René
                      and Wüllner, Ullrich},
      title        = {{R}esting-state f{MRI} reveals increased functional
                      connectivity in the cerebellum but decreased functional
                      connectivity of the caudate nucleus in {P}arkinson's
                      disease.},
      journal      = {Neurological research},
      volume       = {42},
      number       = {1},
      issn         = {0161-6412},
      address      = {Abingdon, Oxon},
      publisher    = {Taylor $\&$ Francis},
      reportid     = {DZNE-2020-00414},
      pages        = {62-67},
      year         = {2020},
      abstract     = {Objective: Frequent falls are common in Parkinson's disease
                      (PD). Resting-state fMRI (rs-fMRI) studies have found
                      differences in functional connectivity between PD patients
                      and healthy controls. However, whether functional
                      connectivity in PD patients with frequent falls (PD-fallers)
                      differs from those without falls (PD-non fallers) is
                      unknown. Therefore, to elucidate the underlying mechanisms
                      leading to postural instability in PD patients with frequent
                      falls, we compared changes in functional connectivity
                      between PD-fallers, PD-non fallers and healthy
                      controls.Methods: Thirteen healthy controls (70.7 ± 7.2
                      years) were compared to thirteen PD-fallers (70.6 ± 5.9
                      years) and 19 PD-non fallers (71.61 ± 5.8 years) without
                      cognitive impairment. We performed 1.5T rs-fMRI scans and
                      evaluated gait and balance, motor symptoms and cognitive
                      functions.Results: Cerebellar seed regions showed increased
                      functional connectivity in PD-fallers compared to controls
                      in two connections between the cerebellar cortex and vermis
                      (p-value = 0.02). Conversely, in comparison to controls,
                      functional connectivity between the precuneus and caudate
                      nucleus was decreased in PD-non fallers (p-value = 0.015). A
                      similar trend was also observed between controls and
                      PD-fallers, although this difference did not reach
                      statistical significance.Discussion: We found increased
                      functional connectivity among cerebellar structures in PD,
                      which may reflect an adaptive (compensatory) mechanism
                      through activation of additional brain structures to restore
                      gait function. In contrast, a relative disconnection between
                      the precuneus and caudate nucleus in PD patients might
                      indicate an impaired brain network unrelated to the risk of
                      falls. Cerebellar areas might thus be considered as future
                      therapeutic targets for neuromodulatory treatment of
                      postural instability in PD.Abbreviations: DMN: default mode
                      network; FC: functional connectivity; IPL: inferior parietal
                      lobule; MMSE: Minimal Mental Status Examination; PD:
                      Parkinson's disease; rs-fMRI: resting-state functional
                      Magnetic Resonance Imaging; UPDRSIII: Unified Parkinson's
                      disease ranking scale.},
      keywords     = {Aged / Caudate Nucleus: diagnostic imaging / Caudate
                      Nucleus: physiopathology / Cerebellum: diagnostic imaging /
                      Cerebellum: physiopathology / Cohort Studies / Female /
                      Follow-Up Studies / Humans / Magnetic Resonance Imaging:
                      methods / Male / Nerve Net: diagnostic imaging / Nerve Net:
                      physiopathology / Parkinson Disease: diagnostic imaging /
                      Parkinson Disease: physiopathology / Rest},
      cin          = {AG Wüllner},
      ddc          = {610},
      cid          = {I:(DE-2719)1011302},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31900094},
      doi          = {10.1080/01616412.2019.1709141},
      url          = {https://pub.dzne.de/record/145054},
}