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| 001 | 145055 | ||
| 005 | 20240321221024.0 | ||
| 024 | 7 | _ | |a 10.1038/s41375-019-0618-2 |2 doi |
| 024 | 7 | _ | |a pmid:31690822 |2 pmid |
| 024 | 7 | _ | |a 0887-6924 |2 ISSN |
| 024 | 7 | _ | |a 1476-5551 |2 ISSN |
| 024 | 7 | _ | |a altmetric:69848010 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-00415 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Riabinska, Arina |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a ATM activity in T cells is critical for immune surveillance of lymphoma in vivo. |
| 260 | _ | _ | |a London |c 2020 |b Springer Nature |
| 264 | _ | 1 | |3 online |2 Crossref |b Springer Science and Business Media LLC |c 2019-11-05 |
| 264 | _ | 1 | |3 print |2 Crossref |b Springer Science and Business Media LLC |c 2020-03-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1704807956_29465 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a The proximal DNA damage response kinase ATM is frequently inactivated in human malignancies. Germline mutations in the ATM gene cause Ataxia-telangiectasia (A-T), characterized by cerebellar ataxia and cancer predisposition. Whether ATM deficiency impacts on tumor initiation or also on the maintenance of the malignant state is unclear. Here, we show that Atm reactivation in initially Atm-deficient B- and T cell lymphomas induces tumor regression. We further find a reduced T cell abundance in B cell lymphomas from Atm-defective mice and A-T patients. Using T cell-specific Atm-knockout models, as well as allogeneic transplantation experiments, we pinpoint impaired immune surveillance as a contributor to cancer predisposition and development. Moreover, we demonstrate that Atm-deficient T cells display impaired proliferation capacity upon stimulation, due to replication stress. Altogether, our data indicate that T cell-specific restoration of ATM activity or allogeneic hematopoietic stem cell transplantation may prevent lymphomagenesis in A-T patients. |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 0 |
| 542 | _ | _ | |i 2019-11-05 |2 Crossref |u http://www.springer.com/tdm |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 2 | |a Alleles |2 MeSH |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Ataxia Telangiectasia Mutated Proteins: metabolism |2 MeSH |
| 650 | _ | 2 | |a Cell Proliferation |2 MeSH |
| 650 | _ | 2 | |a Etoposide: pharmacology |2 MeSH |
| 650 | _ | 2 | |a Hematopoietic Stem Cell Transplantation |2 MeSH |
| 650 | _ | 2 | |a Lymphoma: immunology |2 MeSH |
| 650 | _ | 2 | |a Lymphoma: metabolism |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Mice, Knockout |2 MeSH |
| 650 | _ | 2 | |a T-Lymphocytes: immunology |2 MeSH |
| 650 | _ | 2 | |a T-Lymphocytes: metabolism |2 MeSH |
| 650 | _ | 2 | |a Transplantation, Homologous |2 MeSH |
| 650 | _ | 2 | |a Treatment Outcome |2 MeSH |
| 700 | 1 | _ | |a Lehrmann, Daria |b 1 |
| 700 | 1 | _ | |a Jachimowicz, Ron Daniel |b 2 |
| 700 | 1 | _ | |a Knittel, Gero |b 3 |
| 700 | 1 | _ | |a Fritz, Christian |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Schmitt, Anna |b 5 |
| 700 | 1 | _ | |a Geyer, Aenne |b 6 |
| 700 | 1 | _ | |a Heneweer, Carola |b 7 |
| 700 | 1 | _ | |a Wittersheim, Maike |b 8 |
| 700 | 1 | _ | |a Frenzel, Lukas P |b 9 |
| 700 | 1 | _ | |a Torgovnick, Alessandro |b 10 |
| 700 | 1 | _ | |a Wiederstein, Janica Lea |b 11 |
| 700 | 1 | _ | |a Wunderlich, Claudia Maria |b 12 |
| 700 | 1 | _ | |a Ortmann, Monika |b 13 |
| 700 | 1 | _ | |a Paillard, Arlette |b 14 |
| 700 | 1 | _ | |a Wößmann, Wilhelm |b 15 |
| 700 | 1 | _ | |a Borkhardt, Arndt |b 16 |
| 700 | 1 | _ | |a Burdach, Stefan |b 17 |
| 700 | 1 | _ | |a Hansmann, Martin-Leo |b 18 |
| 700 | 1 | _ | |a Rosenwald, Andreas |b 19 |
| 700 | 1 | _ | |a Perner, Sven |b 20 |
| 700 | 1 | _ | |a Mall, Gita |b 21 |
| 700 | 1 | _ | |a Klapper, Wolfram |0 P:(DE-HGF)0 |b 22 |
| 700 | 1 | _ | |a Merseburg, Andrea |0 P:(DE-2719)2811002 |b 23 |u dzne |
| 700 | 1 | _ | |a Krüger, Marcus |b 24 |
| 700 | 1 | _ | |a Grüll, Holger |b 25 |
| 700 | 1 | _ | |a Persigehl, Thorsten |b 26 |
| 700 | 1 | _ | |a Wunderlich, Frank Thomas |0 P:(DE-HGF)0 |b 27 |
| 700 | 1 | _ | |a Peifer, Martin |b 28 |
| 700 | 1 | _ | |a Utermöhlen, Olaf |b 29 |
| 700 | 1 | _ | |a Büttner, Reinhard |b 30 |
| 700 | 1 | _ | |a Beleggia, Filippo |b 31 |
| 700 | 1 | _ | |a Reinhardt, Hans Christian |b 32 |
| 773 | 1 | 8 | |a 10.1038/s41375-019-0618-2 |b : Springer Science and Business Media LLC, 2019-11-05 |n 3 |p 771-786 |3 journal-article |2 Crossref |t Leukemia |v 34 |y 2019 |x 0887-6924 |
| 773 | _ | _ | |a 10.1038/s41375-019-0618-2 |g Vol. 34, no. 3, p. 771 - 786 |0 PERI:(DE-600)2008023-2 |n 3 |p 771-786 |t Leukemia |v 34 |y 2020 |x 0887-6924 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/145055/files/DZNE-2020-00415.pdf |
| 856 | 4 | _ | |u https://pub.dzne.de/record/145055/files/DZNE-2020-00415.pdf?subformat=pdfa |x pdfa |
| 909 | C | O | |p VDB |o oai:pub.dzne.de:145055 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 23 |6 P:(DE-2719)2811002 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-342 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Disease Mechanisms and Model Systems |x 0 |
| 914 | 1 | _ | |y 2020 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2020-01-10 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2020-01-10 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b LEUKEMIA : 2021 |d 2023-03-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2023-03-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2023-03-30 |
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| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2023-03-30 |
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| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2023-03-30 |
| 915 | _ | _ | |a IF >= 10 |0 StatID:(DE-HGF)9910 |2 StatID |b LEUKEMIA : 2021 |d 2023-03-30 |
| 920 | 1 | _ | |0 I:(DE-2719)1011003 |k AG Isbrandt |l Experimental Neurophysiology |x 0 |
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| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)1011003 |
| 980 | _ | _ | |a UNRESTRICTED |
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