000145065 001__ 145065 000145065 005__ 20240423115938.0 000145065 0247_ $$2ISSN$$a0301-5610 000145065 0247_ $$2doi$$a10.1093/nar/gkz869 000145065 0247_ $$2pmid$$apmid:31598718 000145065 0247_ $$2pmc$$apmc:PMC6943056 000145065 0247_ $$2ISSN$$a0305-1048 000145065 0247_ $$2ISSN$$a0309-1872 000145065 0247_ $$2ISSN$$a1362-4954 000145065 0247_ $$2ISSN$$a1362-4962 000145065 0247_ $$2altmetric$$aaltmetric:68158390 000145065 037__ $$aDZNE-2020-00424 000145065 041__ $$aEnglish 000145065 082__ $$a540 000145065 1001_ $$0P:(DE-HGF)0$$aRahman, Raza-Ur$$b0 000145065 245__ $$aSEAweb: the small RNA Expression Atlas web application. 000145065 260__ $$aLondon$$bInformation Retrieval Ltd.21517$$c2020 000145065 264_1 $$2Crossref$$3online$$bOxford University Press (OUP)$$c2019-10-10 000145065 264_1 $$2Crossref$$3print$$bOxford University Press (OUP)$$c2020-01-08 000145065 3367_ $$2DRIVER$$aarticle 000145065 3367_ $$2DataCite$$aOutput Types/Journal article 000145065 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1713794434_6653 000145065 3367_ $$2BibTeX$$aARTICLE 000145065 3367_ $$2ORCID$$aJOURNAL_ARTICLE 000145065 3367_ $$00$$2EndNote$$aJournal Article 000145065 520__ $$aWe present the Small RNA Expression Atlas (SEAweb), a web application that allows for the interactive querying, visualization and analysis of known and novel small RNAs across 10 organisms. It contains sRNA and pathogen expression information for over 4200 published samples with standardized search terms and ontologies. In addition, SEAweb allows for the interactive visualization and re-analysis of 879 differential expression and 514 classification comparisons. SEAweb's user model enables sRNA researchers to compare and re-analyze user-specific and published datasets, highlighting common and distinct sRNA expression patterns. We provide evidence for SEAweb's fidelity by (i) generating a set of 591 tissue specific miRNAs across 29 tissues, (ii) finding known and novel bacterial and viral infections across diseases and (iii) determining a Parkinson's disease-specific blood biomarker signature using novel data. We believe that SEAweb's simple semantic search interface, the flexible interactive reports and the user model with rich analysis capabilities will enable researchers to better understand the potential function and diagnostic value of sRNAs or pathogens across tissues, diseases and organisms. 000145065 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0 000145065 542__ $$2Crossref$$i2019-10-10$$uhttp://creativecommons.org/licenses/by/4.0/ 000145065 588__ $$aDataset connected to CrossRef, PubMed, 000145065 650_7 $$2NLM Chemicals$$aRNA, Bacterial 000145065 650_7 $$2NLM Chemicals$$aRNA, Small Untranslated 000145065 650_7 $$2NLM Chemicals$$aRNA, Viral 000145065 650_2 $$2MeSH$$aAnimals 000145065 650_2 $$2MeSH$$aBacterial Infections: microbiology 000145065 650_2 $$2MeSH$$aCattle 000145065 650_2 $$2MeSH$$aDatabases, Nucleic Acid 000145065 650_2 $$2MeSH$$aHumans 000145065 650_2 $$2MeSH$$aInternet 000145065 650_2 $$2MeSH$$aMice 000145065 650_2 $$2MeSH$$aOrgan Specificity 000145065 650_2 $$2MeSH$$aParkinson Disease: blood 000145065 650_2 $$2MeSH$$aRNA, Bacterial: metabolism 000145065 650_2 $$2MeSH$$aRNA, Small Untranslated: metabolism 000145065 650_2 $$2MeSH$$aRNA, Viral: metabolism 000145065 650_2 $$2MeSH$$aRats 000145065 650_2 $$2MeSH$$aVirus Diseases: virology 000145065 7001_ $$0P:(DE-HGF)0$$aLiebhoff, Anna-Maria$$b1 000145065 7001_ $$0P:(DE-2719)2812055$$aBansal, Vikas$$b2$$udzne 000145065 7001_ $$0P:(DE-2719)2811935$$aFiosins, Maksims$$b3$$udzne 000145065 7001_ $$0P:(DE-HGF)0$$aRajput, Ashish$$b4 000145065 7001_ $$0P:(DE-HGF)0$$aSattar, Abdul$$b5 000145065 7001_ $$0P:(DE-HGF)0$$aMagruder, Daniel S$$b6 000145065 7001_ $$0P:(DE-HGF)0$$aMadan, Sumit$$b7 000145065 7001_ $$0P:(DE-HGF)0$$aSun, Ting$$b8 000145065 7001_ $$0P:(DE-HGF)0$$aGautam, Abhivyakti$$b9 000145065 7001_ $$0P:(DE-HGF)0$$aHeins, Sven$$b10 000145065 7001_ $$0P:(DE-HGF)0$$aLiwinski, Timur$$b11 000145065 7001_ $$0P:(DE-HGF)0$$aBethune, Jörn$$b12 000145065 7001_ $$0P:(DE-HGF)0$$aTrenkwalder, Claudia$$b13 000145065 7001_ $$0P:(DE-HGF)0$$aFluck, Juliane$$b14 000145065 7001_ $$0P:(DE-HGF)0$$aMollenhauer, Brit$$b15 000145065 7001_ $$0P:(DE-2719)2810547$$aBonn, Stefan$$b16$$eLast author$$udzne 000145065 77318 $$2Crossref$$3journal-article$$a10.1093/nar/gkz869$$bOxford University Press (OUP)$$d2019-10-10$$nD1$$pD204-D219$$tNucleic Acids Research$$v48$$x0305-1048$$y2019 000145065 773__ $$0PERI:(DE-600)1472175-2$$a10.1093/nar/gkz869$$gVol. 48, no. 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