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000145074 0247_ $$2doi$$a10.1117/12.2032904
000145074 037__ $$aDZNE-2020-00433
000145074 041__ $$aEnglish
000145074 1001_ $$aCimalla, Peter$$b0
000145074 1112_ $$aOptical Coherence Tomography and Coherence Techniques VI Conference$$cMunich$$d2013-05-12 - 2013-05-16$$wGermany
000145074 245__ $$aHigh-resolution optical coherence tomography in mouse models of genetic and induced retinal degeneration
000145074 260__ $$c2013
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000145074 520__ $$aFor the study of disease mechanisms and the development of novel therapeutic strategies for retinal pathologies in human, rodent models play an important role. Nowadays, optical coherence tomography (OCT) allows three-dimensional investigation of retinal events over time. However, a detailed analysis of how different retinal degenerations are reflected in OCT images is still lacking in the biomedical field. Therefore, we use OCT to visualize retinal degeneration in specific mouse models in order to study disease progression in vivo and improve image interpretation of this noninvasive modality. We use a self-developed spectral domain OCT system for simultaneous dual-band imaging in the 0.8 μm- and 1.3 μm-wavelength range – the two most common spectral bands in biomedical OCT. A fiber-coupled ophthalmic scanning unit allows flexible imaging of the eye with a high axial resolution of 3 - 4 μm in tissue. Four different mouse models consisting of one genetic (rhodopsin-deficient and three induced retinal degenerations (sodium iodate-induced damage, light-induced photoreceptor damage and Kainate neurotoxin damage) were investigated. OCT imaging was performed daily or weekly, depending on the specific degeneration model, over a time period of up to 9 weeks. Individual retinal layers that were affected by the specific degeneration could successfully be identified and monitored over the observation time period. Therefore, longitudinal OCT studies deliver reliable information about the retinal microstructure and the time course of retinal degeneration processes in vivo.
000145074 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
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000145074 7001_ $$0P:(DE-HGF)0$$aBouma, Brett E.$$b1
000145074 7001_ $$0P:(DE-HGF)0$$aLeitgeb, Rainer A.$$b2
000145074 7001_ $$aCarido, Madalena$$b3
000145074 7001_ $$aPran Babu, Sheik$$b4
000145074 7001_ $$aSantos-Ferreira, Tiago$$b5
000145074 7001_ $$aGaertner, Maria$$b6
000145074 7001_ $$aKordowich, Simon$$b7
000145074 7001_ $$0P:(DE-2719)9001863$$aWittig, Dierk$$b8$$udzne
000145074 7001_ $$aAder, Marius$$b9
000145074 7001_ $$0P:(DE-2719)2000041$$aKarl, Mike$$b10
000145074 7001_ $$aKoch, Edmund$$b11
000145074 773__ $$a10.1117/12.2032904
000145074 8564_ $$uhttps://www.spiedigitallibrary.org/conference-proceedings-of-spie/8802/1/High-resolution-optical-coherence-tomography-in-mouse-models-of-genetic/10.1117/12.2032904.short?tab=ArticleLink
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000145074 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000041$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b10$$kDZNE
000145074 9131_ $$0G:(DE-HGF)POF3-342$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vDisease Mechanisms and Model Systems$$x0
000145074 9141_ $$y2013
000145074 9201_ $$0I:(DE-2719)1710004$$kAG Karl$$lRetinal Regeneration and Degeneration$$x0
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