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@PROCEEDINGS{Cimalla:145074,
      author       = {Cimalla, Peter and Bouma, Brett E. and Leitgeb, Rainer A.
                      and Carido, Madalena and Pran Babu, Sheik and
                      Santos-Ferreira, Tiago and Gaertner, Maria and Kordowich,
                      Simon and Wittig, Dierk and Ader, Marius and Karl, Mike and
                      Koch, Edmund},
      title        = {{H}igh-resolution optical coherence tomography in mouse
                      models of genetic and induced retinal degeneration},
      reportid     = {DZNE-2020-00433},
      year         = {2013},
      abstract     = {For the study of disease mechanisms and the development of
                      novel therapeutic strategies for retinal pathologies in
                      human, rodent models play an important role. Nowadays,
                      optical coherence tomography (OCT) allows three-dimensional
                      investigation of retinal events over time. However, a
                      detailed analysis of how different retinal degenerations are
                      reflected in OCT images is still lacking in the biomedical
                      field. Therefore, we use OCT to visualize retinal
                      degeneration in specific mouse models in order to study
                      disease progression in vivo and improve image interpretation
                      of this noninvasive modality. We use a self-developed
                      spectral domain OCT system for simultaneous dual-band
                      imaging in the 0.8 μm- and 1.3 μm-wavelength range – the
                      two most common spectral bands in biomedical OCT. A
                      fiber-coupled ophthalmic scanning unit allows flexible
                      imaging of the eye with a high axial resolution of 3 - 4 μm
                      in tissue. Four different mouse models consisting of one
                      genetic (rhodopsin-deficient and three induced retinal
                      degenerations (sodium iodate-induced damage, light-induced
                      photoreceptor damage and Kainate neurotoxin damage) were
                      investigated. OCT imaging was performed daily or weekly,
                      depending on the specific degeneration model, over a time
                      period of up to 9 weeks. Individual retinal layers that were
                      affected by the specific degeneration could successfully be
                      identified and monitored over the observation time period.
                      Therefore, longitudinal OCT studies deliver reliable
                      information about the retinal microstructure and the time
                      course of retinal degeneration processes in vivo.},
      month         = {May},
      date          = {2013-05-12},
      organization  = {Optical Coherence Tomography and
                       Coherence Techniques VI Conference,
                       Munich (Germany), 12 May 2013 - 16 May
                       2013},
      cin          = {AG Karl},
      cid          = {I:(DE-2719)1710004},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)26},
      doi          = {10.1117/12.2032904},
      url          = {https://pub.dzne.de/record/145074},
}