Home > Publications Database > Development of a human reporter stem cell line for mature cones in retinal organoids > print

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037 _ _ |a DZNE-2020-00617
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Wieneke, Stephanie
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111 2 _ |a Annual Meeting of the Association for Research in Vision and Ophthalmology
|g ARVO
|c Honolulu, HI
|d 2018-04-29 - 2018-05-03
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245 _ _ |a Development of a human reporter stem cell line for mature cones in retinal organoids
260 _ _ |c 2018
336 7 _ |a Abstract
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520 _ _ |a Purpose : Much of our knowledge about photoreceptor development comes from the mouse retina that is rich in rods but has significantly lower amount of cones. The derivation of three-dimensional (3D) retinal organoids from human stem cells allowed us to study differentiation of human photoreceptors. Therefore, our aim was to develop a fluorescent reporter human induced pluripotent stem cell (hiPSC) line that would allow identification and isolation of postmitotic cones from 3D retinas and further transcriptomic analysis.
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700 1 _ |a Karl, Mike Oliver
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773 _ _ |n 9
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|t Investigative ophthalmology & visual science
|v 59
|y 2018
|x 0146-0404
856 4 _ |u https://iovs.arvojournals.org/article.aspx?articleid=2691050
856 4 _ |u https://pub.dzne.de/record/145260/files/DZNE-2020-00617.pdf
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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