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@INBOOK{Zafar:145422,
      author       = {Zafar, Saima and Noor, Aneeqa and Zerr, Inga},
      title        = {{C}hapter 4 - {T}herapies for prion diseases},
      volume       = {165},
      publisher    = {Elsevier},
      reportid     = {DZNE-2020-00765},
      pages        = {47 - 58},
      year         = {2019},
      comment      = {Handbook of Clinical Neurology},
      booktitle     = {Handbook of Clinical Neurology},
      abstract     = {Recent advances in understanding of the molecular biology
                      of prion diseases and improved clinical diagnostic
                      techniques might allow researchers to think about
                      therapeutic trials in Creutzfeldt–Jakob disease (CJD)
                      patients. Some attempts have been made in the past and
                      various compounds have been tested in single case reports
                      and patient series. Controlled trials are rare. However, in
                      the past few years, it has been demonstrated that clinical
                      trials are feasible. The clinicians might face several
                      specific problems when evaluating the efficacy of the drug
                      in CJD, such as rareness of the disease, lack of appropriate
                      preclinical tests and heterogeneous clinical presentation in
                      humans. These problems have to be carefully addressed in
                      future.},
      cin          = {Ext UMG Zerr / Göttingen Pre 2020 / AG Zerr},
      cid          = {I:(DE-2719)5000037 / I:(DE-2719)6000014 /
                      I:(DE-2719)1440011-1},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)7},
      url          = {https://pub.dzne.de/record/145422},
}