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000145574 041__ $$aEnglish
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000145574 1001_ $$0P:(DE-2719)2810460$$aEngelhardt, Jakob$$b0$$eFirst author$$udzne
000145574 1112_ $$a95th Annual Meeting of the German Physiological Society$$cLübeck$$d2016-03-03 - 2016-03-05$$wGermany
000145574 245__ $$aW01-5: Influence of auxiliary subunits on AMPAR function in hippo-campus and thalamus
000145574 260__ $$c2016
000145574 3367_ $$0PUB:(DE-HGF)1$$2PUB:(DE-HGF)$$aAbstract$$babstract$$mabstract$$s1597314194_1963
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000145574 520__ $$aAuxiliary subunits modulate function, surface trafficking and subcellular localization of AMPA receptors. I will present data from our laboratory on how we investigate the func-tion of auxiliary subunits of the CKAMP and TARP families in heterologous expression systems, acute brain slices and in vivo. Number and properties of synaptic and extrasynaptic AMPA receptors in dentate gyrus granule cells and lateral geniculate relay neurons are strongly influenced by the inter-action with CKAMP44 and TARP y-8. Moreover, these two auxiliary subunits affect synaptic short-term and long-term plasticity. Finally, tetrode recordings from non-anaesthetized mice revealed that auxiliary proteins change the activity of neurons by modulating the integration of excitatory inputs.
000145574 536__ $$0G:(DE-HGF)POF3-341$$a341 - Molecular Signaling (POF3-341)$$cPOF3-341$$fPOF III$$x0
000145574 773__ $$0PERI:(DE-600)2219379-0$$nS707$$pWorkshop 1$$tActa physiologica$$v216$$x0001-6772$$y2016
000145574 8564_ $$uhttps://onlinelibrary.wiley.com/doi/epdf/10.1111/apha.12670
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000145574 9141_ $$y2016
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000145574 9201_ $$0I:(DE-2719)1013023$$kAG Engelhardt$$lSynaptic Signalling and Neurodegeneration$$x0
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